DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Ncam1

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_038936733.1	Gene:	Ncam1 / 24586	RGDID:	67378	Length:	1136	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	109/547 - (19%)
Similarity:	169/547 - (30%)	Gaps:	188/547 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 APN---RSSNNVAINNISNNGDQRLRLTAALEANLIMSNRNVQEQHSYRI-------TQDNATSA 135
            :||   .|.|...|:.:.|:.|         .:.|.:.|.|:.:...|:.       ||..||..
  Rat    56 SPNGEKLSPNQQRISVVWNDDD---------SSTLTIYNANIDDAGIYKCVVTAEDGTQSEATVN 111

  Fly   136 ASI--------APNGTAFGDAPSIPIGVAPATTTTIDPATTTPTTT------------------- 173
            ..|        ||....|.:.....|        ..|..::.|.|.
  Rat   112 VKIFQKLMFKNAPTPQEFKEGEDAVI--------VCDVVSSLPPTIIWKHKGRDVILKKDVRFIV 168

  Fly   174 -----------------TRRTTRRPVA---------TTTLKPPPTIDDYQTII---SQAGTHAYL 209
                             |.|...|.:|         ...:..|||:...|:|:   :..|....|
  Rat   169 LSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTL 233

  Fly   210 PCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQ 274
            .|:.....:..:||  .:||..:..::..   |::  .:||.:..  .|.|:.|...||..|.|
  Rat   234 VCDADGFPEPTMSW--TKDGEPIENEEED---DEK--HIFSDDSS--ELTIRNVDKNDEAEYVC- 288

  Fly   275 VSTEPKASAIVHLRIVEPKTELIGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHN 339
                                  |.|:    |||.|           :..:.:..|...|..|:.|
  Rat   289 ----------------------IAEN----KAGEQ-----------DASIHLKVFAKPKITYVEN 316

  Fly   340 RRGWRTEIERIDLPAEV---PTTSTTTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATSSETL 401
            :.....| |::.|..|.   |..|.|..|:|...|:....:.|.|              ...|||
  Rat   317 QTAMELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRP--------------EKQETL 366

  Fly   402 NGLVTI-----TRSYILDAISQNDVSELGAAAGVAVATETSTAQLLTEVEATSSTSGTSTGAGLL 461
            :|.:.:     ..|..|.:|...|..|....|...:..::.:..|  ||:......|
  Rat   367 DGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYL--EVQYAPKLQG-------- 421

  Fly   462 ASTSAAYA-AGAAAGITTAATGDSAATAATTSAWLTTMDAEAATTAATTTTTMLPSSSF--IKQI 523
              ..|.|. .|....||.    :..|..:.|.:|.  .|.:           :||||::  ||..
  Rat   422 --PVAVYTWEGNQVNITC----EVFAYPSATISWF--RDGQ-----------LLPSSNYSNIKIY 467

  Fly   524 TTAS---LIIPAVVKLDSGNYTCSPSN 547
            .|.|   |.:....:.|.|||.|:..|
  Rat   468 NTPSASYLEVTPDSENDFGNYNCTAVN 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	19/94 (20%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	17/85 (20%)
Ncam1	XP_038936733.1	IgI_1_NCAM-1	20..116	CDD:409451	16/68 (24%)
		Ig strand B	37..41	CDD:409451
		Ig strand C	51..55	CDD:409451
		Ig strand E	79..83	CDD:409451	1/3 (33%)
		Ig strand F	93..98	CDD:409451	1/4 (25%)
		Ig strand G	107..110	CDD:409451	1/2 (50%)
		IG_like	124..190	CDD:214653	8/73 (11%)
		Ig strand B	135..139	CDD:409353	1/11 (9%)
		Ig strand C	148..152	CDD:409353	1/3 (33%)
		Ig strand E	172..176	CDD:409353	0/3 (0%)
		Ig strand F	186..191	CDD:409353	2/4 (50%)
		IgI_3_NCAM-1	211..308	CDD:143207	29/143 (20%)
		Ig strand B	231..235	CDD:143207	1/3 (33%)
		Ig strand C	244..248	CDD:143207	2/5 (40%)
		Ig strand E	271..275	CDD:143207	1/5 (20%)
		Ig strand F	285..290	CDD:143207	2/27 (7%)
		Ig strand G	298..301	CDD:143207	0/2 (0%)
		IgI_NCAM-1	307..413	CDD:143277	26/122 (21%)
		Ig strand B	326..330	CDD:143277	1/3 (33%)
		Ig strand C	339..343	CDD:143277	2/3 (67%)
		Ig strand E	379..383	CDD:143277	1/3 (33%)
		Ig strand F	393..398	CDD:143277	1/4 (25%)
		Ig strand G	406..409	CDD:143277	0/2 (0%)
		Ig_3	422..494	CDD:404760	23/88 (26%)
		Ig strand B	433..437	CDD:409353	1/3 (33%)
		Ig strand C	446..450	CDD:409353	1/3 (33%)
		Ig strand E	473..477	CDD:409353	1/3 (33%)
		Ig strand F	487..492	CDD:409353	3/4 (75%)
		FN3	509..606	CDD:238020
		fn3	619..701	CDD:394996
		Herpes_BLLF1	<842..1133	CDD:282904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900