DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Kirrel2

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus

Alignment Length:	425	Identity:	87/425 - (20%)
Similarity:	140/425 - (32%)	Gaps:	131/425 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 PPTIDDYQTIISQAGTHAYLPCNV---KQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSP 251
            |..:...:.::...|..|.|||.:   :.||:    |  .:||..|
Mouse    21 PHFLQQPEDMVVLLGEEARLPCALGAYRGLVQ----W--TKDGLAL------------------- 60

  Fly   252 NPER----WS--------------LQIKYVQLKDEGTYECQVSTEPKAS--AIVHLRIVEPKTEL 296
            ..||    ||              |.||.|:|:||.:||||.|.....|  |.:|:.:.....::
Mouse    61 GGERDLPGWSRYWISGNSASGQHDLHIKPVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQV 125

  Fly   297 IGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTST 361
            :|..:..:.||....|.|.......|...:.||          |.|.|.:             .:
Mouse   126 LGGPSVSLVAGVPGNLTCRSRGDSRPAPELLWF----------RDGIRLD-------------GS 167

  Fly   362 TTTTTTTTASTTTTTTSTTPATPSTTATGST-----------EGATSSETLN----GLVTITR-- 409
            :...||.....|.|..:|...|||:...|:|           .|..::.||:    .:||::.
Mouse   168 SFHQTTLKDKATGTVENTLFLTPSSHDDGATLICRARSQALPTGRDTAVTLSLQYPPMVTLSAEP 232

  Fly   410 ---------SYILDAISQNDVSELGAAAGVAVATETSTAQLLTEVEATSSTSGTSTGAGLLASTS 465
                     :::..|.:|..|:....|.|.:........:|....:||..|..        .|..
Mouse   233 QTVQEGEKVTFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADATFLTEP--------VSCE 289

  Fly   466 AAYAAGAAAGITT--------------AATGDSAATAATTSAWLTTMDAEAATTAATTTTTMLPS 516
            .:.|.|:|...|.              :.:.|....|:.:..|       ........|.|.:..
Mouse   290 VSNAVGSANRSTALEVLYGPILQAKPKSVSVDVGKDASFSCVW-------RGNPLPRITWTRMGG 347

  Fly   517 SSFIKQITTASLIIPAVVKLDSGNYTCSPSNSAPR 551
            |..:....|  |.:|:|...|:|:|.|   .:.||
Mouse   348 SQVLSSGPT--LRLPSVALEDAGDYVC---RAEPR 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	30/114 (26%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	30/108 (28%)
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	29/113 (26%)
		Ig	122..220	CDD:416386	24/120 (20%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	0/3 (0%)
		Ig strand B	140..147	CDD:409353	2/6 (33%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	0/4 (0%)
		Ig strand C'	161..163	CDD:409353	1/1 (100%)
		Ig strand D	166..173	CDD:409353	0/6 (0%)
		Ig strand E	180..188	CDD:409353	2/7 (29%)
		Ig strand F	197..205	CDD:409353	1/7 (14%)
		Ig strand G	211..217	CDD:409353	1/5 (20%)
		Ig_3	223..292	CDD:404760	12/76 (16%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	255..259	CDD:409353	0/3 (0%)
		Ig strand E	272..275	CDD:409353	1/2 (50%)
		Ig strand F	281..290	CDD:409353	2/16 (13%)
		Ig strand G	298..301	CDD:409353	0/2 (0%)
		Ig	315..392	CDD:416386	16/75 (21%)
		Ig strand A'	316..321	CDD:409353	0/4 (0%)
		Ig strand B	324..333	CDD:409353	2/15 (13%)
		Ig strand C	339..343	CDD:409353	1/3 (33%)
		Ig strand C'	346..348	CDD:409353	0/1 (0%)
		Ig strand D	351..354	CDD:409353	0/2 (0%)
		Ig strand E	355..360	CDD:409353	2/6 (33%)
		Ig strand F	368..376	CDD:409353	3/10 (30%)
		Ig strand G	382..392	CDD:409353
		Ig	394..498	CDD:416386
		Ig strand A	395..399	CDD:409353
		Ig strand A'	401..404	CDD:409353
		Ig strand B	412..419	CDD:409353
		Ig strand C	426..431	CDD:409353
		Ig strand C'	433..436	CDD:409353
		Ig strand D	444..451	CDD:409353
		Ig strand E	461..468	CDD:409353
		Ig strand F	479..486	CDD:409353
		Ig strand G	489..496	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900