DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Cadm2

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_011244430.1	Gene:	Cadm2 / 239857	MGIID:	2442722	Length:	458	Species:	Mus musculus

Alignment Length:	472	Identity:	103/472 - (21%)
Similarity:	150/472 - (31%)	Gaps:	112/472 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 QTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERW---SL 258
            |.:....|..|.|.|.|.|.....:.|..... ..|..|....:.|.|.:.|.:    .|   |:
Mouse    53 QNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQ-QTLYFDDKKALRDNRIELVRA----SWHELSI 112

  Fly   259 QIKYVQLKDEGTYECQVSTEPKASAIVHLRI--VEPKTELIGESTRHVKAGSQVKLRCIISQALE 321
            .:..|.|.|||.|.|.:.|.|..::..:|.:  |..|.::.|.|: .|..|..::|.|..|.: :
Mouse   113 SVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSS-PVMEGDLMQLTCKTSGS-K 175

  Fly   322 PPLFINWFYNQKQI----YLH----NRRGWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTS 378
            |...|.||.|.|:|    ||.    ||:                                   |.
Mouse   176 PAADIRWFKNDKEIKDVKYLKEEDANRK-----------------------------------TF 205

  Fly   379 TTPATPSTTATGSTEGA-----TSSETLNGLVTITRSYILDAISQNDVSELGAAAGVAVATETST 438
            |..:|.......|.:|.     ...|:||....:..          .|.|:.....|.:...|..
Mouse   206 TVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAM----------QVLEIHYTPSVKIIPSTPF 260

  Fly   439 AQLLTEVEATSSTSG---------TSTGAGLLASTSAAYAAGAAAGITTAATGDSAATAATTSAW 494
            .|....:..|..:.|         |..||. |........:|....|......|:.......:..
Mouse   261 PQEGQALTLTCESKGKPLPEPVLWTKDGAE-LPDPDRMVVSGRELNILFLNKTDNGTYRCEATNT 324

  Fly   495 LTTMDAEAATTAATTTTTMLPSSSFIKQITTASLIIPAVVKLDSGNYTCSPSNSAPRTIVLHVLN 559
            :....||..........|:|| ::.|..:|||.:.....:       |.|||.||.
Mouse   325 IGQSSAEYVLIVHDVPNTLLP-TTIIPSLTTAPVTTSVTI-------TTSPSTSAS--------- 372

  Fly   560 GEYSASAIKSGSVSWS-----ALIGCHGYLHWRNVSTLLTLLWIIKFALARDICQPNATSKATTR 619
               |:|.....|::..     ||||  |.:   .|...:||..|  |.|.|.:.:...|......
Mouse   373 ---SSSRRDPNSLAGQNGPDHALIG--GIV---AVVVFVTLCSI--FLLGRYLARHKGTYLTNEA 427

  Fly   620 TSLLRAGDGATADVTRE 636
            .....|.|..||.:..|
Mouse   428 KGAEDAPDADTAIINAE 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	25/94 (27%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	24/90 (27%)
Cadm2	XP_011244430.1	MtrA	<9..>56	CDD:392200	1/2 (50%)
		Ig1_Necl-3	49..143	CDD:319327	25/94 (27%)
		Ig2_Necl-3	164..246	CDD:319320	23/127 (18%)
		IGc2	263..326	CDD:197706	9/63 (14%)
		4.1m	411..429	CDD:128590	3/17 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I12439
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I5205
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960