DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Sdk2

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_766388.2	Gene:	Sdk2 / 237979	MGIID:	2443847	Length:	2176	Species:	Mus musculus

Alignment Length:	563	Identity:	115/563 - (20%)
Similarity:	188/563 - (33%)	Gaps:	148/563 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 MAQTLDKASA--FRPTMAAALDAAAPNRSSNNVAINNISNNGDQRLRL----TAALEANLIMS-- 115
            |..:||:..|  :|..:...:.|....::...||.......|::|..:    .|.:.|..|.|
Mouse    81 MITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKRQSVNHGEAAVIRAPRISSFP 145

  Fly   116 ---------NRNVQEQHSYRITQDNA-TSAASIAPN-GTAFGDAPSIPIGVAPATTTTIDPATTT 169
                     .|.:.......||.:|. ...:::||: |..:..|.:...|         |..|:.
Mouse   146 RPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNG---------DNKTSQ 201

  Fly   170 PTTTTRRTT---RRPVATTTLKPPPTIDDYQTIISQAGTHAYLPC--NVKQLVKKPISWLRMRDG 229
            |.|......   ..|:|.|.:.||.     .|.:....:...:.|  |.:.|:|..|.|  .:||
Mouse   202 PITLAVENVGGPADPIAPTIIIPPK-----NTSVVAGTSEVTMECVANARPLIKLHIVW--KKDG 259

  Fly   230 HILTVDQTTFIAD-QRFQSVFSPNPERWSLQIKYVQLKDEGTYECQVSTEPKASAIV----HLRI 289
            ..|    ::.|:| .|..::.:|.            :.|.|.|||:......:.|.|    :|.:
Mouse   260 APL----SSGISDYNRRLTIANPT------------VSDAGYYECEAMLRSSSVAPVTRGAYLSV 308

  Fly   290 VEPKTELIGESTRHVKAGSQ--VKLRCIISQALEPPLFINWF-------------YNQK------ 333
            :|| .:.:.|..||:.|..:  |.:.|.....  ||..|.|:             :.|:
Mouse   309 LEP-PQFVREPERHITAEMEKVVDIPCRAKGV--PPPSITWYKDAALVEVGKLTRFKQRSDGGLQ 370

  Fly   334 ------------QIYLHNRRGWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATPST 386
                        |.:.||..|            |..|::....|:.....|.....||.....|.
Mouse   371 ISGLLPDDTGMLQCFAHNAAG------------EAQTSTYLAVTSIAPNITRGPLDSTVIDGMSV 423

  Fly   387 TATGSTEGA-------TSSETL--NGLVTITRSYILDA----ISQNDVSELGAAAGVAV---ATE 435
            .....|.||       ...|.:  :|.|.:.|..:|::    ||...:|:.|....:|.   ..:
Mouse   424 VLACETSGAPRPAITWQKGERILASGSVQLPRFTLLESGSLLISPTHISDAGTYTCLATNSRGVD 488

  Fly   436 TSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITTAATGDSAATAATTSAWLTTMDA 500
            .::|.|:  |.|.:..:.......::..|.|:...|        .|.|...|  ....|    :.
Mouse   489 EASADLV--VWARTRITKPPQDQSVIKGTQASMVCG--------VTHDPRVT--VRYVW----EK 537

  Fly   501 EAATTAATTTTTMLPSSSFIKQITTASLIIPAVVKLDSGNYTC 543
            :.||.|..|...       |:.....||.|......|.|.|||
Mouse   538 DGATLAVETNPR-------IRLDRNGSLHISQTWSGDIGTYTC 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	22/98 (22%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	21/92 (23%)
Sdk2	NP_766388.2	IG_like	44..113	CDD:214653	6/31 (19%)
		IGc2	44..102	CDD:197706	5/20 (25%)
		IG_like	124..207	CDD:214653	18/91 (20%)
		Ig	136..192	CDD:299845	11/55 (20%)
		IG_like	226..308	CDD:214653	22/104 (21%)
		IGc2	237..290	CDD:197706	18/70 (26%)
		I-set	312..401	CDD:254352	17/102 (17%)
		Ig	330..398	CDD:143165	13/81 (16%)
		I-set	406..496	CDD:254352	19/91 (21%)
		Ig	420..496	CDD:299845	16/77 (21%)
		Ig	506..590	CDD:299845	20/89 (22%)
		IG_like	506..590	CDD:214653	20/89 (22%)
		FN3	594..685	CDD:238020
		FN3	697..790	CDD:238020
		FN3	798..894	CDD:238020
		FN3	899..987	CDD:238020
		FN3	997..1091	CDD:238020
		FN3	1103..1198	CDD:238020
		FN3	1205..1294	CDD:238020
		FN3	1305..1398	CDD:238020
		FN3	1404..1488	CDD:238020
		FN3	1507..1620	CDD:238020
		FN3	1630..1723	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1712..1734
		FN3	1728..1809	CDD:238020
		FN3	1841..1920	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2013..2032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2043..2070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2102..2176
		PDZ-binding. /evidence=ECO:0000269\|PubMed:20219992	2170..2176
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810