DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and Ptprq

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001357916.1	Gene:	Ptprq / 237523	MGIID:	1096349	Length:	2301	Species:	Mus musculus

Alignment Length:	753	Identity:	137/753 - (18%)
Similarity:	232/753 - (30%)	Gaps:	298/753 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IRGQAEETSILNSNGTNGRAFQ-RTQSRREALIPATTQ--MAQTLDKASAFRPTMAAALDAAAPN 83
            :|.:.:...:|.:|...|..:: :..:...|.|...:.  :.||.:.|    |.....|...|.|
Mouse   108 VRAKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESA----PGKVVNLTVEALN 168

  Fly    84 RSSNNVAINNI-----SNNGDQRLRLTAALEANLIMSNRNVQEQHSYRITQDNATSAASIAPNGT 143
            .|    |:|.|     ..||    ::|                  |::|:..:|.|...:.....
Mouse   169 YS----AVNLIWYLPRQPNG----KIT------------------SFKISVKHARSGIVVKDVSI 207

  Fly   144 AFGDAPSIPIGVAPATTTTIDP---ATTTPTTTTRRTT---------------------RRPVA- 183
            ...|..|   |..|......|.   :||:|:.|..|.|                     :.|::
Mouse   208 KVEDLLS---GKLPECNENSDSFLWSTTSPSPTLSRATPPLRTTHLSNTLARNKISSVWKEPISF 269

  Fly   184 -TTTLKPPPT-IDDYQTIISQAGTHAYLPCNVKQLVKKP----------------------ISW- 223
             .|.|:|..| :.:...:.::||   |:...:   |:.|                      |||
Mouse   270 VVTHLRPYTTYLFEVSAVTTEAG---YIDSTI---VRTPESVPEGPPQNCITGNVTGKAFSISWD 328

  Fly   224 --------------LRMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQ 274
                          |....|.||  |.:|  .|.||  ||:             .|.....|:..
Mouse   329 PPAIVTGKFSYRVELYGPTGRIL--DNST--KDLRF--VFT-------------HLTPFTMYDVY 374

  Fly   275 VSTE------PKAS-----------AIVHLRIVEPKTELIGESTRHVKAG----SQVKLRCIISQ 318
            |:.|      ||::           |:..|:|||.:...|..|.|..:..    ||.:::..:.:
Mouse   375 VAAETSAGVGPKSNLSVFTPPDVPGAVFDLQIVEVEATEIRVSWRKPRQPNGIISQYRVKVSVLE 439

  Fly   319 A---LEPPL------FIN---------------WFY---NQKQIYLHNRRGW-----------RT 345
            :   ||..|      :||               .||   .:....||:...:           ||
Mouse   440 SGVILENTLLTGQDEYINNPMTPEIMNLVDPMIGFYEGSGEMSSDLHSLASFIYNSHPHDFPART 504

  Fly   346 EIE--------------RIDLPAE---------VPTTSTTTTTTTTT----ASTTTTTTSTTPAT 383
            .:|              ..|:.||         ||.|..|.:.:..|    ...|..|..|....
Mouse   505 RVEDQRSPVVVATRNQYMTDIAAEHLSYVIRRLVPFTEHTISVSAFTVMGEGPPTVLTVRTREQV 569

  Fly   384 PSTTATGSTEGATSSETL---------NGLVTITRSYILDAISQNDVSELGAAAGVAVATETSTA 439
            ||:....:.:..:||..|         ||.:|....|                   |:..:|:.|
Mouse   570 PSSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIY-------------------AMELDTNRA 615

  Fly   440 QLLTEVEATSSTSG--------------TSTGAGLLASTSAAY---------AAGAAAGITTAAT 481
            ..:|.|:.:...:|              |..|...|:..:..:         ::.....:|..:.
Mouse   616 FQMTTVDNSFLITGLKKYTRYKMRVAASTHVGESSLSEENDLFVRTPEDEPESSPQDVKVTDVSP 680

  Fly   482 GDSAATAATTSAW--------------LTTMDAEAATTAATTTTTMLPSSSFIKQITTASLIIPA 532
            .:.:.|      |              :...:|:|.....|:||.:  :.|.:|..|..::.|.:
Mouse   681 SELSLT------WSPPEKPNGIIIAYEVFYQNADALFVKNTSTTNI--TLSDLKPYTLYNISIQS 737

  Fly   533 VVKLDSGNYTCS---------PSNSAPRTIVLHVLNGE 561
            ..:|..||.:.|         ..:|||..|....::.|
Mouse   738 YTRLGHGNQSSSLLSVRTSETVPDSAPENITYKNISSE 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	27/145 (19%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	26/139 (19%)
Ptprq	NP_001357916.1	FN3	57..151	CDD:238020	6/42 (14%)
		FN3	308..393	CDD:238020	20/103 (19%)
		fn3	399..>441	CDD:365830	10/41 (24%)
		FN3	570..654	CDD:238020	18/102 (18%)
		fn3	668..744	CDD:365830	13/83 (16%)
		FN3	762..850	CDD:238020	5/14 (36%)
		fn3	857..934	CDD:365830
		FN3	951..1049	CDD:238020
		FN3	1056..1137	CDD:238020
		FN3	1152..1233	CDD:238020
		FN3	1247..1337	CDD:238020
		FN3	1342..1421	CDD:238020
		FN3	1432..1535	CDD:238020
		FN3	1542..1638	CDD:238020
		FN3	1645..1734	CDD:238020
		UP_III_II	1759..1928	CDD:297589
		R-PTPc-Q	2033..2256	CDD:350464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900