DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr15 and DSCAM

DIOPT Version :9

Sequence 1:NP_001287299.1 Gene:dpr15 / 41473 FlyBaseID:FBgn0037993 Length:662 Species:Drosophila melanogaster
Sequence 2:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens


Alignment Length:444 Identity:87/444 - (19%)
Similarity:139/444 - (31%) Gaps:146/444 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   169 TPTTTTRRTTRRPVATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILT 233
            |..|....:.|..|:......|..:|.:....:.||....|||......:....||:        
Human   204 TGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLK-------- 260

  Fly   234 VDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQVSTE-PKASAIVHLRIVEPKTELI 297
             |........|||...:      .|.|:.::..|.|:|.|:||.. ..|..|..|.:.:|....|
Human   261 -DNMPLELSGRFQKTVT------GLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATI 318

  Fly   298 GESTRHVKA--GSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTS 360
              |.|.||:  ||||.|.|.::...:..|  :|:.|                             
Human   319 --SPRKVKSSVGSQVSLSCSVTGTEDQEL--SWYRN----------------------------- 350

  Fly   361 TTTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATSSETLN--GLVTIT----RSYILDAISQN 419
                                                 .|.||  ..|.||    .:.|:|.:.::
Human   351 -------------------------------------GEILNPGKNVRITGINHENLIMDHMVKS 378

  Fly   420 DVSELGAAAGVAVATETSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITTAATGDS 484
            |    |.|....|..:..:||...:|.       ...|...:.|..:......|..::...  :.
Human   379 D----GGAYQCFVRKDKLSAQDYVQVV-------LEDGTPKIISAFSEKVVSPAEPVSLMC--NV 430

  Fly   485 AATAATTSAWLTTMD------------AEAATTAATTTTTMLPSSSFIKQITTASLIIPAVVKLD 537
            ..|...|..|  |:|            ::..|:.....:.:..|||.::               |
Human   431 KGTPLPTITW--TLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVR---------------D 478

  Fly   538 SGNYTCSPSNSAPRTIVLHV----LNGEYSASAIKSGSVSWSALIGCHGYLHWR 587
            .|.|.|:.:|||  .:||:.    :.|..|...:|    :.:|:.|...|:|.|
Human   479 GGVYRCTANNSA--GVVLYQARINVRGPASIRPMK----NITAIAGRDTYIHCR 526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr15NP_001287299.1 IG_like 197..289 CDD:214653 22/92 (24%)
V-set 204..290 CDD:284989 21/86 (24%)
DSCAMNP_001380.2 Ig 45..113 CDD:319273
I-set 235..310 CDD:254352 22/89 (25%)
I-set 315..385 CDD:333254 25/143 (17%)
Ig_3 407..488 CDD:316449 15/99 (15%)
IGc2 518..575 CDD:197706 4/9 (44%)
I-set 596..686 CDD:333254
Ig_DSCAM 707..784 CDD:143211
Ig 802..889 CDD:325142
FN3 885..978 CDD:238020
FN3 986..1083 CDD:238020
FN3 1091..1184 CDD:238020
FN3 1189..1278 CDD:238020
Ig 1303..1369 CDD:319273
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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