DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and sax-3

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001024990.1	Gene:	sax-3 / 180637	WormBaseID:	WBGene00004729	Length:	1273	Species:	Caenorhabditis elegans

Alignment Length:	431	Identity:	95/431 - (22%)
Similarity:	145/431 - (33%)	Gaps:	114/431 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 QTIISQAGTHAYLPCNVKQLVKKP-ISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQI 260
            :|:.:..|..|.|.|:..:...:| :|| |..|..:...|...:........:..|
Worm   140 RTVQALGGEMAVLECSPPRGFPEPVVSW-RKDDKELRIQDMPRYTLHSDGNLIIDP--------- 194

  Fly   261 KYVQLKDEGTYECQVSTEPKASAIVHLRIVEPKTELIGESTRH--------VKAGSQVKLRCIIS 317
              |...|.|||:|      .|:.:|..|:..|....:.|..:.        |..|:.|...|.::
Worm   195 --VDRSDSGTYQC------VANNMVGERVSNPARLSVFEKPKFEQEPKDMTVDVGAAVLFDCRVT 251

  Fly   318 QALEPPLFINWFYNQK-----QIYL-HNRRGWRTEIERIDLPAE--------------------- 355
            ...:|.  |.|....:     :.|: .:.||.|  |||:. |::
Worm   252 GDPQPQ--ITWKRKNEPMPVTRAYIAKDNRGLR--IERVQ-PSDEGEYVCYARNPAGTLEASAHL 311

  Fly   356 ----VPTTSTTTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATSSETLNGLVTITRSYILDAI 416
                .|:..|.....:..|..|.|...|....||.....|.||..                 |.:
Worm   312 RVQAPPSFQTKPADQSVPAGGTATFECTLVGQPSPAYFWSKEGQQ-----------------DLL 359

  Fly   417 SQNDVSELGAAAGVAVATETSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITT-AA 480
            ..:.||..|       .|:.|....||..|......|....||:  :::.:..:.||..:|| |.
Worm   360 FPSYVSADG-------RTKVSPTGTLTIEEVRQVDEGAYVCAGM--NSAGSSLSKAALKVTTKAV 415

  Fly   481 TGDSAATAATT--------------SAWLTTMDAEAATTAATTTTTMLP---SSSFIKQITTASL 528
            ||::.|....|              ||.|....:...|...:.....||   :.|.|.|.:|.||
Worm   416 TGNTPAKPPPTIEHGHQNQTLMVGSSAILPCQASGKPTPGISWLRDGLPIDITDSRISQHSTGSL 480

  Fly   529 IIPAVVKLDSGNYTCSPSN-------SAPRTIVLHVLNGEY 562
            .|..:.|.|:|.|||...|       ||..|:..|..|.::
Worm   481 HIADLKKPDTGVYTCIAKNEDGESTWSASLTVEDHTSNAQF 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	20/92 (22%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	20/86 (23%)
sax-3	NP_001024990.1	Ig	30..129	CDD:299845
		I-set	31..121	CDD:254352
		I-set	135..223	CDD:254352	22/100 (22%)
		Ig2_Robo	137..223	CDD:143201	22/100 (22%)
		I-set	227..313	CDD:254352	15/90 (17%)
		Ig	244..313	CDD:299845	13/73 (18%)
		I-set	317..410	CDD:254352	25/118 (21%)
		Ig	331..411	CDD:299845	22/105 (21%)
		Ig	424..512	CDD:299845	23/87 (26%)
		I-set	432..512	CDD:254352	22/79 (28%)
		FN3	531..624	CDD:238020
		FN3	659..747	CDD:238020
		FN3	755..836	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910