DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Ncam2

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus

Alignment Length:	660	Identity:	125/660 - (18%)
Similarity:	197/660 - (29%)	Gaps:	212/660 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 QRLRL-TAALEANLIMSNRNVQEQHSYRITQDNATSAASIAPNGTAFGDAPSIPIGVAPATTTTI 163
            ||:.| ...:.:.|.:.|.|:::...||.   .||.|..                        ..
Mouse    65 QRVMLQKEGVRSRLTIYNANIEDAGIYRC---QATDAKG------------------------QT 102

  Fly   164 DPATTTPTTTTRRTTRRPVATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRD 228
            ..||.......:.|.|..|:....|              .|..|.:.|.|.......:|||...
Mouse   103 QEATVVLEIYQKLTFREVVSPQEFK--------------QGEDAEVVCRVSSSPAPAVSWLYHN- 152

  Fly   229 GHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQVSTEPKAS-------AIVH 286
                  ::.|.|.|.|| :|.:.|    :|||..:...|||.|.|:...|.:..       .||:
Mouse   153 ------EEVTTIPDNRF-AVLANN----NLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVN 206

  Fly   287 L--RIVEPKTELIGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNR---RGWRTE 346
            :  .|:.|:......:.|    |.::.|.|..|.:.:|.  |:||.|.|.|..:.:   :|..||
Mouse   207 VPPAIMMPQKSFNATAER----GEEMTLTCKASGSPDPT--ISWFRNGKLIEENEKYILKGSNTE 265

  Fly   347 I---------------------------ERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATP 384
            :                           ..:.:..:.........||:.....|....:.....|
Mouse   266 LTVRNIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPHILQLKNETTSENGHVTLVCEAEGEPVP 330

  Fly   385 STTATGSTEGATSSE---TLNGLVTITRSYILDAISQNDV--SELGAAAGVAVATETSTAQLLTE 444
            ..|...:.:|...||   :.:|.:.:...:...::...||  |:.|.                .:
Mouse   331 EITWKRAIDGVMFSEGDKSPDGRIEVKGQHGRSSLHIRDVKLSDSGR----------------YD 379

  Fly   445 VEATSSTSGTSTGAGL-------LASTSAAYAAGAAAGITTAATGDSAATAATTSAWLTTMDAEA 502
            .||.|...|......|       ..|....|.:.....|..:.  |..|....:..|    ..|.
Mouse   380 CEAASRIGGHQRSMHLDIEYAPKFVSNQTMYYSWEGNPINISC--DVTANPPASIHW----RREK 438

  Fly   503 ATTAATTTTTMLPSSSFIKQITTASLIIPAVVKLDSGNYTCSPSN-----------------SAP 550
            ....|..||.:...|...|.|    |.|......|.|.|.|:.:|                 |:|
Mouse   439 LLLPAKNTTHLKTHSVGRKMI----LEIAPTSDNDFGRYNCTATNRIGTRFQEYILELADVPSSP 499

  Fly   551 RTIVLHVLN-------------------GEYSASAIKSGSVSWSALIGCHGYLHWRNVSTLLTLL 596
            ..:.:..|:                   ..|.....:..|.:|. ::..||      |.|::.|
Mouse   500 HGVKIIELSQTTAKISFNKPESHGGVPIHHYQVDVKEVASETWK-IVRSHG------VQTMVVL- 556

  Fly   597 WIIKFALARDICQPNATSKATTRTSLLRA---GDGATADV-----TRETG-------PKSGASFH 646
                     ...:||.|.:  .|.:.:..   ||.:..::     .||..       |.||.||
Mouse   557 ---------SSLEPNTTYE--IRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSF- 609

  Fly   647 RVSSSISATK 656
                .||.||
Mouse   610 ----KISITK 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	25/100 (25%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	25/94 (27%)
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274	13/73 (18%)
		I-set	22..111	CDD:254352	13/72 (18%)
		I-set	117..193	CDD:254352	26/101 (26%)
		IGc2	128..189	CDD:197706	22/72 (31%)
		Ig	208..301	CDD:299845	17/98 (17%)
		I-set	215..298	CDD:254352	15/88 (17%)
		Ig	300..397	CDD:299845	18/112 (16%)
		IG_like	308..395	CDD:214653	17/102 (17%)
		IG_like	413..491	CDD:214653	18/87 (21%)
		IGc2	414..482	CDD:197706	18/77 (23%)
		FN3	496..588	CDD:238020	17/110 (15%)
		fn3	594..678	CDD:278470	9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900