DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Ncam1

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_006510118.1	Gene:	Ncam1 / 17967	MGIID:	97281	Length:	1162	Species:	Mus musculus

Alignment Length:	628	Identity:	136/628 - (21%)
Similarity:	211/628 - (33%)	Gaps:	195/628 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LIPATTQMAQTLDKASAFRPTMAAALDAAAPNRSSNNVAINNI----SNNGDQ--RLRLTAALEA 110
            |:.|.|..:.::|:...:..|.....|..   .::..|.|...    .:.|::  ..:...|.||
Mouse   505 LVQADTPSSPSIDRVEPYSSTAQVQFDEP---EATGGVPILKYKAEWKSLGEESWHFKWYDAKEA 566

  Fly   111 NL-----IMSNRNVQEQHSYRITQDNATSAASIAPNGTAFGDAP-SIPIGVAPATTTTIDP---- 165
            |:     ||..: .:.::|.|:...|......|:. .|.|...| ..|..:|||.::|:.|
Mouse   567 NMEGIVTIMGLK-PETRYSVRLAALNGKGLGEISA-ATEFKTQPVHSPPPLAPANSSTLVPLSPR 629

  Fly   166 ATTTPTTTTRRTTRRPVATTT--LKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRD 228
            |||.|.         ||..||  .|..|:....:..:.:.|.      ::|      ::.::..|
Mouse   630 ATTWPL---------PVLPTTDLSKGEPSAPKLEGQMGEDGN------SIK------VNLIKQDD 673

  Fly   229 G-----HILTVDQTTFIADQRFQSVFSPNPERWSLQIK------YVQLKD---EGTYECQVSTE- 278
            |     |.|...:....::             |..:|:      :|.||.   ...||..|..|
Mouse   674 GGSPIRHYLVKYRAKLASE-------------WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAEN 725

  Fly   279 ----PKASAIVHLRIVEPKT-ELIGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQK----- 333
                .||:..|.....:|.. ...|..|..:..|:.|.:..:|...|...:.|..::..|
Mouse   726 QQGKSKAAHFVFRTSAQPTAIPANGSPTAGLSTGAIVGILIVIFVLLLVVMDITCYFLNKCGLLM 790

  Fly   334 --QIYLHNRRG--------------------------WRTEIERI-------------------- 350
              .:.|..:.|                          .|||.||.
Mouse   791 CIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEP 855

  Fly   351 DLPAE--------VPTTSTTTTTTTT------------TASTTTTTTSTTP-------------- 381
            :|||:        :|:.:|.||.:.|            |:.|||.|:|..|
Mouse   856 ELPADTTATVEDMLPSVTTVTTNSDTITETFATAQNSPTSETTTLTSSIAPPATTVPDSNSVPAG 920

  Fly   382 -ATPSTTATGSTEGATSSETLNGLV----TITRSYILDAISQNDVSELGAA---AGVAVATETST 438
             ||||...|.|:....|:..:..||    |.|.:.....:|...::..||.   :..|.|.|||.
Mouse   921 QATPSKGVTASSSSPASAPKVAPLVDLSDTPTSAPSASNLSSTVLANQGAVLSPSTPASAGETSK 985

  Fly   439 AQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGA--AAGITTAATGDSAATAATTSAWLTTMDAE 501
            |...::    :|.:.|.|.|| .||..||.||.|  |......|..........|.........|
Mouse   986 APPASK----ASPAPTPTPAG-AASPLAAVAAPATDAPQAKQEAPSTKGPDPEPTQPGTVKNPPE 1045

  Fly   502 AATTAATTTTTMLPSSSFIKQITTASLIIPAV---VKLDSGNY 541
            |||.         |:|...|..||.    |:.   :|:|.||:
Mouse  1046 AATA---------PASPKSKAATTN----PSQGEDLKMDEGNF 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	18/110 (16%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	18/104 (17%)
Ncam1	XP_006510118.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652
		Ig3_NCAM-1_like	211..308	CDD:143207
		Ig_NCAM-1	307..413	CDD:143277
		Ig_3	417..494	CDD:372822
		FN3	509..606	CDD:238020	19/101 (19%)
		fn3	649..731	CDD:365830	15/106 (14%)
		PHA03247	<905..1140	CDD:223021	50/189 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900