DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and Dscam

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_038943864.1	Gene:	Dscam / 171119	RGDID:	619992	Length:	2034	Species:	Rattus norvegicus

Alignment Length:	602	Identity:	106/602 - (17%)
Similarity:	189/602 - (31%)	Gaps:	178/602 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RGQAEETSIL--NSNGTNGRAFQRTQSRREALIPATTQMAQTLDKASAFRPTMAAALDAAAPNRS 85
            |.|...|.:|  ||..::..::....|.|..       .|:.:.:....:|..|........:..
  Rat   270 RFQKTVTGLLIENSRPSDSGSYVCEVSNRYG-------TAKVIGRLYVKQPLKATISPRKVKSSV 327

  Fly    86 SNNVAIN-NISNNGDQRL---------------RLTAALEANLIMSNRNVQEQHSYR--ITQDNA 132
            .:.|::: :::.|.||.|               |:|....|||||.:....:..:|:  :.:|..
  Rat   328 GSQVSLSCSVTGNEDQELSWYRNGEILNPGKNVRITGLNHANLIMDHMVKSDGGAYQCFVRKDKL 392

  Fly   133 TS---AASIAPNGT-----AFGD---APSIPIGVA--------PATTTTIDPATTTPTTTTR--- 175
            ::   ...:..:||     ||.:   :|:.|:.:.        |..|.|:|.......:..|
  Rat   393 SAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLVCNVKGTPLPTVTWTLDDDPILKGSGHRISQ 457

  Fly   176 -------------------------RTTRRPVATTTL-------KPPPTIDDYQTIISQAGTHAY 208
                                     |.|....|...|       :.|.:|...:.|.:.||...|
  Rat   458 MITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTY 522

  Fly   209 LPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLK-DEGTYE 272
            :.|.|.......|.|  .::.::|..:..        |..|..|   .:|::..||.: |||.|.
  Rat   523 IHCRVIGYPYYSIKW--YKNANLLPFNHR--------QVAFENN---GTLKLSDVQKEVDEGEYT 574

  Fly   273 CQVSTEPK--ASAIVHLRIVEPKTELIGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQI 335
            |.|..:|:  .|..||:.:..|......|..| ...|.:|.:.|::... :.|:.|.|   ||.
  Rat   575 CNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPR-FSIGQRVFIPCVVVSG-DLPITITW---QKD- 633

  Fly   336 YLHNRRGWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATSSET 400
                             ...:|.:...|.......|:...:..:.....:.|.....|.|.....
  Rat   634 -----------------GRPIPASLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQ 681

  Fly   401 LNGLVTITRSYILDAISQNDVSELGAAAGVAVATETSTAQLLTEVEATSSTSGTSTGAGLLASTS 465
            ...:|.:...:::....|:.:
  Rat   682 SQLIVRVPPKFVVQPRDQDGI-------------------------------------------- 702

  Fly   466 AAYAAGAAAGITTAATGDSAATAATTSAWLTTMDAEAATTAATTTTTMLPSSSFIKQITTASLII 530
                .|.|..:..:|.|    ....|..|      :.:..|.......:..:..|:.::..||:|
  Rat   703 ----YGKAVILNCSAEG----YPVPTIVW------KFSKGAGVPQFQPIALNGRIQVLSNGSLLI 753

  Fly   531 PAVVKLDSGNYTCSPSN 547
            ..||:.|||.|.|..||
  Rat   754 KHVVEEDSGYYLCKVSN 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	25/94 (27%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	23/88 (26%)
Dscam	XP_038943864.1	Ig	26..121	CDD:416386
		Ig strand A'	33..37	CDD:409353
		Ig strand B	40..49	CDD:409353
		Ig strand C	55..61	CDD:409353
		Ig strand C'	63..66	CDD:409353
		Ig strand D	72..75	CDD:409353
		Ig strand E	80..85	CDD:409353
		Ig strand F	98..106	CDD:409353
		Ig strand G	109..121	CDD:409353
		Ig	125..210	CDD:416386
		Ig strand A	126..130	CDD:409353
		Ig strand A'	132..136	CDD:409353
		Ig strand B	139..149	CDD:409353
		Ig strand C	157..163	CDD:409353
		Ig strand C'	164..167	CDD:409353
		Ig strand E	179..185	CDD:409353
		Ig strand F	191..201	CDD:409353
		IGc2	239..300	CDD:197706	8/29 (28%)
		Ig strand B	242..246	CDD:409353
		Ig strand C	255..259	CDD:409353
		Ig strand F	290..295	CDD:409353	0/4 (0%)
		Ig	313..395	CDD:416386	16/81 (20%)
		Ig strand A	314..319	CDD:409353	1/4 (25%)
		Ig strand A'	322..326	CDD:409353	0/3 (0%)
		Ig strand B	329..339	CDD:409353	1/9 (11%)
		Ig strand C	344..350	CDD:409353	1/5 (20%)
		Ig strand C'	351..354	CDD:409353	0/2 (0%)
		Ig strand E	368..374	CDD:409353	5/5 (100%)
		Ig strand F	381..389	CDD:409353	1/7 (14%)
		Ig	406..501	CDD:416386	14/94 (15%)
		Ig strand A	406..409	CDD:409353	1/2 (50%)
		Ig strand A'	415..419	CDD:409353	0/3 (0%)
		Ig strand B	422..431	CDD:409353	1/8 (13%)
		Ig strand C	436..442	CDD:409353	2/5 (40%)
		Ig strand C'	444..447	CDD:409353	0/2 (0%)
		Ig strand D	452..460	CDD:409353	1/7 (14%)
		Ig strand E	464..473	CDD:409353	0/8 (0%)
		Ig strand F	480..488	CDD:409353	2/7 (29%)
		Ig strand G	491..501	CDD:409353	1/9 (11%)
		Ig	504..593	CDD:416386	27/101 (27%)
		Ig strand A	505..507	CDD:409353	0/1 (0%)
		Ig strand A'	512..516	CDD:409353	1/3 (33%)
		Ig strand B	519..526	CDD:409353	1/6 (17%)
		Ig strand C	533..539	CDD:409353	2/7 (29%)
		Ig strand C'	540..542	CDD:409353	0/1 (0%)
		Ig strand D	549..553	CDD:409353	1/11 (9%)
		Ig strand E	557..563	CDD:409353	1/5 (20%)
		Ig strand F	571..579	CDD:409353	4/7 (57%)
		Ig strand G	583..593	CDD:409353	3/9 (33%)
		Ig	596..686	CDD:416386	17/112 (15%)
		Ig strand A	597..599	CDD:409353	0/1 (0%)
		Ig strand B	611..620	CDD:409353	2/8 (25%)
		Ig strand C	625..632	CDD:409353	3/9 (33%)
		Ig strand C'	634..636	CDD:409353	0/1 (0%)
		Ig strand D	643..648	CDD:409353	1/4 (25%)
		Ig strand E	651..658	CDD:409353	1/6 (17%)
		Ig strand F	665..673	CDD:409353	1/7 (14%)
		Ig strand G	676..685	CDD:409353	1/8 (13%)
		Ig_DSCAM	689..784	CDD:409397	21/140 (15%)
		Ig strand B	707..711	CDD:409397	0/3 (0%)
		Ig strand C	720..724	CDD:409397	2/9 (22%)
		Ig strand E	749..753	CDD:409397	2/3 (67%)
		Ig strand F	763..768	CDD:409397	2/4 (50%)
		Ig strand G	777..780	CDD:409397
Ig_DSCAM	785..884	CDD:409398
Ig strand B	805..809	CDD:409398
Ig strand C	818..822	CDD:409398
Ig strand E	848..852	CDD:409398
Ig strand F	862..867	CDD:409398
Ig strand G	875..878	CDD:409398
FN3	885..978	CDD:238020
FN3	986..1083	CDD:238020
FN3	1091..1184	CDD:238020
FN3	1189..1278	CDD:238020
Ig_3	1287..1363	CDD:404760
Ig strand B	1303..1307	CDD:409353
Ig strand C	1316..1320	CDD:409353
Ig strand E	1342..1346	CDD:409353
Ig strand F	1356..1361	CDD:409353
FN3	1380..1470	CDD:238020
FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900