DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Kirrel

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_011238330.1	Gene:	Kirrel / 170643	MGIID:	1891396	Length:	805	Species:	Mus musculus

Alignment Length:	478	Identity:	106/478 - (22%)
Similarity:	175/478 - (36%)	Gaps:	82/478 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 TSAASIAPNGTAFGD----APSIPIGVAPATTTTIDPATTTPTTTTRRTTRRPVATTTLKPPPTI 193
            |..:|:.|....|..    ||.:.:    |....:..|...|.|.| |.::.|..
Mouse    12 TCQSSLLPEKPRFLSQKMWAPHLVV----AYLIFVTLALALPGTQT-RFSQEPAD---------- 61

  Fly   194 DDYQTIISQAGTHAYLPC---NVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPER 255
               ||::  ||..|.|||   |...:|:    |  .:||..|.:.| ...|..|::.|.|.:..:
Mouse    62 ---QTVV--AGQRAVLPCVLLNYSGIVQ----W--TKDGLALGMGQ-GLKAWPRYRVVGSADAGQ 114

  Fly   256 WSLQIKYVQLKDEGTYECQVSTEPKASAIVHLRIVEP--KTELIGESTRHVKAGSQVKLRCIISQ 318
            ::|:|...:|.|:.:||||.:.....|....|.::.|  :|.:.|.....::||:...|.|....
Mouse   115 YNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEETRIDGGPVILLQAGTPYNLTCRAFN 179

  Fly   319 ALEPPLFINWFYNQKQIYLHNRRGWRTEIERI-DLPAEVPTTSTTTTTTTTTASTTTTTTSTTPA 382
            | :|...|.||.:..|     :.|..|..|.: |...|...:......|........|..|...|
Mouse   180 A-KPAATIIWFRDGTQ-----QEGAVTSTELLKDGKRETTISQLLIEPTDLDIGRVFTCRSMNEA 238

  Fly   383 TPS-------------TTATGSTEGATSSETLNGLVTITRSYILDAISQNDVSELGAAAGVAVAT 434
            .|:             .|.|.|.|..|   .|.|...|   :...|.:..::.....|.|..:..
Mouse   239 IPNGKETSIELDVHHPPTVTLSIEPQT---VLEGERVI---FTCQATANPEILGYRWAKGGFLIE 297

  Fly   435 ETSTAQLLTEVEATSSTSGTS------TGAGLLASTSAAYAAGAAAGITTAATGDSAATAATTSA 493
            :...::..|.|:.:..|...|      .|:..:::....:.|..........|.|..:....|..
Mouse   298 DAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLVNVHFAPRIVVYPKPTTTDIGSDVTLTCV 362

  Fly   494 W-----LTTMDAEAATTAATTTTTMLPSSSFIKQITTAS--LIIPAVVKLDSGNYTCSP----SN 547
            |     ||....:..:..........|.::...|:.:.|  |::.:|.:.|:|.|||..    ..
Mouse   363 WVGNPPLTLTWTKKDSNMGPRLPGSPPEANLSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIG 427

  Fly   548 SAPRTIVLHVLNGE--YSASAIK 568
            .|.|.:.|:| ||.  .|:.|::
Mouse   428 VAEREVPLYV-NGPPIISSEAVQ 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	29/94 (31%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	26/88 (30%)
Kirrel	XP_011238330.1	Ig	54..148	CDD:386229	31/115 (27%)
		Ig2_KIRREL3-like	170..251	CDD:143236	18/86 (21%)
		Ig	255..336	CDD:386229	16/86 (19%)
		Ig_3	340..421	CDD:372822	16/80 (20%)
		Ig5_KIRREL3	439..536	CDD:143306	3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810