DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and AgaP_AGAP012059

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_320464.4	Gene:	AgaP_AGAP012059 / 1280607	VectorBaseID:	AGAP012059	Length:	464	Species:	Anopheles gambiae

Alignment Length:	564	Identity:	106/564 - (18%)
Similarity:	172/564 - (30%)	Gaps:	202/564 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 TTTRRTTRRPVATTTLKPPPTIDDYQ--TIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTV 234
            |..:..|..|.|.:.|..|.|:..|:  |::        |||    ....|..::|.....:|.|
Mosquito    27 TNRQIVTGNPAAGSFLSVPTTVKRYENDTVL--------LPC----YHNAPYRYVRWSRDDLLLV 79

  Fly   235 DQTTFIADQRFQSVFSPNPER-W---SLQIKYVQLKDEGTYECQVSTE-PKASAIVHLRIVEPKT 294
                   |.|:..:.:|...| |   ||::..||..|.|.|.|::.|: .|||....:.:....|
Mosquito    80 -------DSRYPDLRTPPRMRLWPNGSLEVTEVQTDDTGDYTCEIMTDGGKASQHHAIEVQFQAT 137

  Fly   295 ELI-GESTRHVKAGSQVKLRCIISQALEPPLFINWFYN-----QKQIYLHNRRGWRTEIERIDLP 353
            ..| .|....::.|..::..|.::...:|  ::.|...     :...:..|.|.....||
Mosquito   138 AAIYPEDPIDIRVGQILEAVCQVTGMPQP--YVKWMMQVGHTVEPLPHFRNERKLNVLIE----- 195

  Fly   354 AEVPTTSTTTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATSSETLNGLVTITRSYILDAISQ 418
                                                        ..|.:|.:..|        :.
Mosquito   196 --------------------------------------------DRTFSGPLQCT--------AT 208

  Fly   419 NDVSELGAAAGVAVATETSTAQLLTEVEATSSTSGTSTG-AGLLASTSAAYAAG----------- 471
            |.|.|..:||...:      ...:.|:|..|.|..|..| .|||.....|:.|.
Mosquito   209 NGVGEPASAAVEVI------VNFVPEIEVKSPTVHTRIGETGLLECLVTAHPAASIHWFHHGLPV 267

  Fly   472 --------------------------AAAGITTAATGDSAATAATTSAWLTTMDAEAATTAATTT 510
                                      |...:..|..|.....|...   :....|:...|.....
Mosquito   268 VYDRRIVKLDTLVTKHQYYTVQRHQLAIRSLRDADLGQYECKAGNR---VGIAGAQLELTGRPMV 329

  Fly   511 TTMLPSS--------SFIKQITTASLIIPAVVK---LDSGNYTCSPSNSAPRTIVLHVLNGEYSA 564
            .:..|::        :||.|..:.|.:|...:|   :.|||.|  |..   ||:
Mosquito   330 ASFKPAAEMSSPTRHNFIWQTESHSPLIEYKLKFRRVPSGNVT--PGR---RTL----------- 378

  Fly   565 SAIKSGSVSWSALI----GCHGYLHWRNVSTLLTLLWIIKFALARDICQPNATSKA--------- 616
                ....:|..||    |.:|.||    |:..||          :..||.:..:.
Mosquito   379 ----PQQFAWKELIIPSDGSYGPLH----SSGYTL----------EGLQPTSVYEVIVLSRNRYG 425

  Fly   617 -TTRTSLLRAGDGATADVTRETGPKSGASFHRVSSSISATKVAE 659
             :..:::||...|...::  |.|.::..|   .|||:..|:..|
Mosquito   426 WSDPSNILRFATGGEVEI--EPGSEADTS---SSSSVQTTETLE 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	25/98 (26%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	24/90 (27%)
AgaP_AGAP012059	XP_320464.4	IG_like	45..132	CDD:214653	28/105 (27%)
		Ig	56..125	CDD:299845	22/87 (25%)
		IG_like	149..223	CDD:214653	16/138 (12%)
		Ig	158..222	CDD:299845	15/122 (12%)
		I-set	227..324	CDD:254352	16/99 (16%)
		IGc2	240..315	CDD:197706	10/77 (13%)
		FN3	<348..437	CDD:238020	25/122 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900