DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and AgaP_AGAP009688

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_318747.4	Gene:	AgaP_AGAP009688 / 1279077	VectorBaseID:	AGAP009688	Length:	785	Species:	Anopheles gambiae

Alignment Length:	390	Identity:	83/390 - (21%)
Similarity:	126/390 - (32%)	Gaps:	127/390 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ILNSNGTNGRAFQRTQSRREALIPATTQ---------------------MAQTLDKASAFR---- 70
            |.|.|||.|..        |.:||...|                     :..|:.....||
Mosquito   447 INNENGTIGTT--------ELIIPNIQQAGAGKYQCIITNNYGVVYSPKVKVTVGTYPKFRKTPS 503

  Fly    71 -----PTMAAALDAAAPNRSSNNVAINNISNNG-----DQRLRLTAALEANLIMSNRNVQ--EQH 123
                 |...|.|:.||.......:.......|.     ::|:.:....:|.||:   |||  :..
Mosquito   504 DVSVEPGKVARLNCAAMGDPKPQIYWEKDGGNDFPAAKERRMHVIPNEDAFLIL---NVQLVDMG 565

  Fly   124 SYRITQDNATSAASIAPNGTAFGDAPSIPIGVAPATTTTIDPATTTPTTTTRRTTRRPVATTTLK 188
            .|..|.:|                    |.||..|..:.|        .....|..|||.
Mosquito   566 VYSCTAEN--------------------PAGVIRANASVI--------VLESETAARPVT----- 597

  Fly   189 PPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNP 253
                  :.:|.|.:|   :.:.|.|....|..|.||  :||..:.:.:..||..
Mosquito   598 ------NLETAIGKA---SVIECKVSASPKPVIFWL--KDGEPIGLTERHFITG----------- 640

  Fly   254 ERWSLQIKYVQLKDEGTYECQVSTE-PKASAIVHLRIVEPKTEL----IGES-TRHVKAGSQVKL 312
            |...|.|...:..|.|.|||:...| ........|.:|:...::    :||: |.....|....:
Mosquito   641 EGQLLVIVDTEQTDAGLYECRFENEIISEGGSTRLTVVDGPEDMHGSVLGETGTYGAGGGGLALI 705

  Fly   313 RCIISQALEPPLFINWFYN-QKQIYLHNRRGW-----RTEIE-----RIDLPAEVPTTSTTTTTT 366
            .||:   |...:::...|. ||:|    |||.     .||::     .|:.|..:..:...|:||
Mosquito   706 GCIV---LTSCIWMCCLYRMQKRI----RRGGSGCPKETELDLATGMEINQPNLIVRSGVGTSTT 763

Fly 367 366
Mosquito 764 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	23/92 (25%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	20/86 (23%)
AgaP_AGAP009688	XP_318747.4	LRR_RI	<1..219	CDD:238064
		LRR_8	16..76	CDD:290566
		leucine-rich repeat	18..41	CDD:275380
		leucine-rich repeat	42..65	CDD:275380
		LRR_8	65..147	CDD:290566
		leucine-rich repeat	66..89	CDD:275380
		leucine-rich repeat	90..136	CDD:275380
		LRR_8	136..195	CDD:290566
		leucine-rich repeat	137..160	CDD:275380
		LRR_RI	139..345	CDD:238064
		leucine-rich repeat	161..184	CDD:275380
		LRR_8	183..243	CDD:290566
		leucine-rich repeat	185..208	CDD:275380
		leucine-rich repeat	209..232	CDD:275380
		leucine-rich repeat	233..256	CDD:275380
		LRR_8	255..318	CDD:290566
		leucine-rich repeat	257..283	CDD:275380
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..328	CDD:275380
		LRRCT	342..389	CDD:214507
		I-set	395..492	CDD:254352	10/52 (19%)
		Ig	412..483	CDD:143165	10/43 (23%)
		I-set	496..586	CDD:254352	23/120 (19%)
		Ig	513..587	CDD:299845	20/104 (19%)
		I-set	594..677	CDD:254352	26/109 (24%)
		Ig	596..677	CDD:299845	24/107 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910