DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and AgaP_AGAP007928

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_317553.4	Gene:	AgaP_AGAP007928 / 1278027	VectorBaseID:	AGAP007928	Length:	1478	Species:	Anopheles gambiae

Alignment Length:	598	Identity:	114/598 - (19%)
Similarity:	183/598 - (30%)	Gaps:	169/598 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PATTQMAQTLDKASAF----RPTMAAALDAAAPNRSSNNVAINNISNNGDQRLRLTAALEANLIM 114
            |...:..|.|.::.::    .|..:.....|:|.|..:  |..:..|....|..:|:.
Mosquito     7 PGVFRWCQALSRSRSYATKTTPKTSPRQALASPGRCCS--AREDDRNTDASRSAITSG------- 62

  Fly   115 SNRNVQEQHSYRITQDNATSAASIAPNGTAFGDAPSI----PIGVAPATTTTIDPATTTPTTTTR 175
                   .||...|..|.||::|.:..|....|.|.:    ...|...|:|..:...   |||:.
Mosquito    63 -------THSKVKTVSNYTSSSSTSDAGHVHEDNPLLTGQYSARVRRRTSTDSNGGR---TTTSD 117

  Fly   176 RTTRRPVA-----------TTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDG 229
            ::..|.::           ..|:.||   .|...|.:..|......|:|....:.|:.::...:.
Mosquito   118 KSLNRLISFLLLALCFTLGCCTINPP---QDAVHITAILGESVVFNCHVDFPGEHPVPYVLQWEK 179

  Fly   230 HILTVDQ--TTFIADQRFQ-----------SVFSPNPE--RWSLQIKYVQLKDEGTYECQV---- 275
            .:....|  ..||..:.:.           |...||..  ..||.:..::..|:|.|||:|
Mosquito   180 KVSEKGQEIPIFIWYESYPTHSGEGYEGRVSRVPPNSTFGAASLNLTDIRESDQGWYECKVVFLN 244

  Fly   276 --STEPKASAIVHLRI-VEPKTELIGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYL 337
              ..:.|.....||.: ..|:..:..|...:|..|..:.|.|.......|.:.  |:
Mosquito   245 RPPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPEIL--WY-------- 299

  Fly   338 HNRRGWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATSSETLN 402
                                                   ....|..||     ||.|..:..|..
Mosquito   300 ---------------------------------------KDANPVDPS-----STVGIFNDGTEL 320

  Fly   403 GLVTITRSYILD--AISQNDVSELGAAAGVAVATETSTAQLLTEVEATSSTSGTSTGAGLLA-ST 464
            .:.||....|.|  .|::|...::...|.|.:|                      .||.::. .|
Mosquito   321 RISTIRHEDIGDYTCIARNGEGQVSHTARVIIA----------------------GGAVIMVPPT 363

  Fly   465 SAAYAAGAAAGITTAATGDSAATAATTSAWLTTMDAEAATTAATTTTTMLPSSSFIKQITTASLI 529
            :.....|.....|..|   .|.....|..|...........|..|..|:...         .|||
Mosquito   364 NQTKLEGEKVQFTCEA---KAMPGNVTVRWFREGSPVREVAALETRVTIRKD---------GSLI 416

  Fly   530 IPAVVKLDSGNYTCSPSN--SAPRTIVLHVLNGEYSASAIKSGSVSW-----SALIGCH------ 581
            |..|...|||.|||..||  ..|::...: ||.||.|....:.::.:     :.::.|:
Mosquito   417 INPVSADDSGQYTCEVSNGIGEPQSASAY-LNIEYPAKVTFTPTIQYLPFRLAGVVQCYIKANPP 480

  Fly   582 -GYLHWRNVSTLL 593
             .|:.|.....||
Mosquito   481 LQYVTWTKDKRLL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	22/112 (20%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	21/107 (20%)
AgaP_AGAP007928	XP_317553.4	IG_like	148..240	CDD:214653	18/91 (20%)
		Ig	155..241	CDD:299845	16/85 (19%)
		I-set	264..352	CDD:254352	23/141 (16%)
		IGc2	279..342	CDD:197706	18/116 (16%)
		I-set	357..448	CDD:254352	25/103 (24%)
		Ig	<387..448	CDD:299845	20/70 (29%)
		Ig	470..541	CDD:299845	5/24 (21%)
		IG_like	560..636	CDD:214653
		IGc2	562..625	CDD:197706
		FN3	641..733	CDD:238020
		FN3	765..839	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810