DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and AgaP_AGAP004902

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_001688600.1	Gene:	AgaP_AGAP004902 / 1275709	VectorBaseID:	AGAP004902	Length:	1874	Species:	Anopheles gambiae

Alignment Length:	703	Identity:	123/703 - (17%)
Similarity:	193/703 - (27%)	Gaps:	283/703 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 IAPNGTAFGDAPSI------------PIGVAPATTTTIDPATT----TPTTTTRRTTRRPVATTT 186
            ::.:||:.||...:            |.   |||....|..:|    ..:.|..|...|.|....
Mosquito    32 LSVDGTSVGDVGGVRRVLRNGTLVLLPF---PATAYRQDIHSTIYRCVASNTVGRVISRDVQVRA 93

  Fly   187 LKPPPTIDDYQTIISQAGTHAYLPCNVKQLVK---KPISWL------------------------ 224
            :.......|.:.:.:..|..|.|.|.|...||   :.:||:
Mosquito    94 VVAQAYKVDVEVLAASRGCTAILRCVVPNFVKELVRVVSWVQEPAFYIYPSLQGDGKYHLLPTGE 158

  Fly   225 ---------------RMRDGHILT------------------------VDQTTFIADQRFQSVF- 249
                           |.|..|.||                        |:.|:.:|..:.:...
Mosquito   159 LLIHNLEYNDRYPSYRCRTMHKLTRQVVTSNSAKIRMNEQRGIVSPSVVEHTSHVAVSQDEGAVL 223

  Fly   250 ------SPNPE-RW----------------------SLQIKYVQLKDEGTYECQVSTE-PKASAI 284
                  .|:|| ||                      .|.|:.|..:|.|.|:|..|.. .:|||.
Mosquito   224 LCVAQGCPSPEYRWYTHNGPEPIPVSSGPRIRLLGPVLAIEAVTAEDGGVYKCSASNAGGEASAD 288

  Fly   285 VHLRIVEPKTELIGESTRHVKAGSQVKLRCIISQ--ALEPPLFINWFYNQKQIYLHNRRG----- 342
            :.|.:..|....|..:...|..|...:.||:::.  ....|..|.||.:.:|:....|.|
Mosquito   289 LRLTVSTPIHVEITPNVLSVHMGGTAEFRCLVTANGMSAGPQHITWFKDGRQLPSSGRVGDTLQV 353

  Fly   343 ---------------WRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATPSTTATGST 392
                           .|.|.:.....||:.......:...:...      .|....|:.:...|.
Mosquito   354 TGVTREDKGMYQCVVRRQEGDSFQASAELQLGDAPPSLVYSFIE------QTLQPGPAVSLKCSA 412

  Fly   393 EGATSSE---TLNGLVTITRSYIL---------DAISQNDVS--------ELGAAAGVAVATETS 437
            :|..:.:   ||:|....|....:         |.||..::|        |...||.......:.
Mosquito   413 QGNPTPQIAWTLDGFPLPTNGRFMIGQYVTVHGDVISHVNISHVMVEDGGEYSCAAENRAGKTSH 477

  Fly   438 TA----------QLLTEVEATS-----------------------------------STSGT--- 454
            :|          :|:.:|.|.:                                   .:.||
Mosquito   478 SARLNIYGLPYIRLIPKVTAVAGHTLYLKCPVAGYPIEEIHWERGGRELPEDMRQKVQSDGTLEI 542

  Fly   455 -----STGAGLL---ASTSAAYAA---------------------GAAAGI-TTAATGDSAATAA 489
                 |..:|:.   |.....::|                     |.|.|: |....|.|.....
Mosquito   543 KEVQKSLDSGVYTCWARNKQGHSARRSGEVAVIVPPNIEPFSFQDGLAEGMRTRTVCGVSKGDPP 607

  Fly   490 TTSAWLTTMDAEAATTAATTTTTMLPSSSFIKQITTASLIIPAVVKLDSGNYTCSPSNSA----- 549
            .|..||...|...:|......:|:...||.:.        ||::....||:|||..||.|
Mosquito   608 LTLKWLKDGDPLLSTLLGANVSTLDQYSSLLN--------IPSLSAAHSGDYTCVASNPAAEVKF 664

  Fly   550 ---------PRTIV--------------LHVLNGEYSASAIKSGSVSWSALIG 579
                     ||.:|              ||.     .|..:...::.|....|
Mosquito   665 TASLQVKVPPRWVVEPTDVSVERNRHIMLHC-----QAQGVPVPTILWKKATG 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	34/188 (18%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	34/182 (19%)
AgaP_AGAP004902	XP_001688600.1	Ig	<17..88	CDD:299845	12/58 (21%)
		I-set	204..293	CDD:254352	20/88 (23%)
		Ig	222..293	CDD:299845	17/70 (24%)
		I-set	298..383	CDD:254352	16/84 (19%)
		IGc2	310..369	CDD:197706	10/58 (17%)
		IG_like	398..483	CDD:214653	16/84 (19%)
		IGc2	402..473	CDD:197706	14/70 (20%)
		IG_like	493..576	CDD:214653	8/82 (10%)
		IGc2	500..563	CDD:197706	5/62 (8%)
		I-set	572..670	CDD:254352	24/105 (23%)
		Ig	598..667	CDD:143165	20/76 (26%)
		IG_like	680..768	CDD:214653	5/38 (13%)
		Ig	691..768	CDD:299845	5/27 (19%)
		I-set	772..860	CDD:254352
		Ig	786..875	CDD:299845
		FN3	872..963	CDD:238020
		FN3	970..1068	CDD:238020
		FN3	1076..1170	CDD:238020
		FN3	1175..1269	CDD:238020
		Ig	1292..1362	CDD:299845
		FN3	1364..1454	CDD:238020
		FN3	1459..1542	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910