DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and AgaP_AGAP010422

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_311526.4	Gene:	AgaP_AGAP010422 / 1272626	VectorBaseID:	AGAP010422	Length:	427	Species:	Anopheles gambiae

Alignment Length:	440	Identity:	85/440 - (19%)
Similarity:	147/440 - (33%)	Gaps:	109/440 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 GTHAYLPCNVKQLVKKP---ISWLRMRDGHILTVDQTTFIADQRF-----QSVFSPN---PERWS 257
            |:...|||.:.:.....   ::|  .||..:||........:.|.     |:...|:   ...::
Mosquito    44 GSTVVLPCKINETENSSQYVLAW--KRDIAVLTAGNVKVTVNPRIRLMPVQAHTDPHGSLSTGYN 106

  Fly   258 LQIKYVQLKDEGTYECQV-STEPKASAIVHLR--IVEPKTELIGESTR-HVKAGSQVKLRCIISQ 318
            |:|:.|:..|.|.|.||: |.|||  .|||..  :|.||.:.|..|.: .:..|:.:::.|..|.
Mosquito   107 LEIRDVRNSDAGDYICQIGSMEPK--EIVHTLEILVPPKIDYISPSNKMDIHKGAPIRMECRASG 169

  Fly   319 ALEPPLFINWFYNQKQI-------------YLH--------------NRRG---WRTEIERIDLP 353
              .|...|.|......:             .||              ||.|   .|.....:..|
Mosquito   170 --NPTPKIVWSRKNNMMPNGEANKTGNVLDILHANRHSSGHYKCTADNRVGQPDTREVFVNVLYP 232

  Fly   354 AEVPTTSTTTTTTTTTASTTTTTTSTTPATPS------TTATGSTEGATSSETLNGLVTITRSYI 412
            .|:.....|..:.....:.........| |||      ||..|.||..:.....|....:.|:
Mosquito   233 PEIEVEQPTVHSGIGHEAQLVCIVHGEP-TPSVVWYQDTTQLGITEQFSQQNRGNKYSLVIRN-- 294

  Fly   413 LDAISQNDVSELGAAAGVAVATETSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGIT 477
               ::.:|:......|..|:..:..|..|          ||..|.....|.|.::|.
Mosquito   295 ---VTYSDIGNYTCQASNALGKDRGTLSL----------SGLPTLCYFDAPTLSSYR-------- 338

  Fly   478 TAATGDSAATAATTSAWLTTMDAEAATTAATTTTTMLPSSSFIKQITTASLIIPAVVKLDSGNYT 542
                 |....:.|..::....:.......|:.:..:|...:                .||:..|:
Mosquito   339 -----DQYNISWTVQSYSPIREYRLFFRLASKSMHLLHHEN----------------PLDNHIYS 382

  Fly   543 CSPSNSAPRTIVLHVLNGEYSASAIKSGSVSWSALIGCHGYLHWRNVSTL 592
            ..|:.::      |:.:..:|.|.:|..| ::.|.:.......|..:|::
Mosquito   383 DRPATNS------HLYSSPFSGSNLKPAS-NYEARVQARNDHGWNKLSSI 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	27/98 (28%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	27/99 (27%)
AgaP_AGAP010422	XP_311526.4	Ig	37..127	CDD:299845	20/84 (24%)
		IG_like	37..123	CDD:214653	18/80 (23%)
		I-set	142..229	CDD:254352	16/88 (18%)
		IGc2	158..218	CDD:197706	10/61 (16%)
		IG_like	232..321	CDD:214653	19/104 (18%)
		IGc2	246..312	CDD:197706	14/71 (20%)
		fn3	339..423	CDD:278470	15/106 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810