DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and AgaP_AGAP000217

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_310917.4	Gene:	AgaP_AGAP000217 / 1272050	VectorBaseID:	AGAP000217	Length:	856	Species:	Anopheles gambiae

Alignment Length:	548	Identity:	106/548 - (19%)
Similarity:	168/548 - (30%)	Gaps:	194/548 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 TQDNATSAASIAPNGTAFGDAPSIPIGVAPATTTTI------DPA-------------------- 166
            ::::.|...|..|:..    ||...:...|.||.|:      :||
Mosquito   341 SEESVTLDISYGPSFR----APPQSVEADPDTTVTLGCDVDGNPAPDVLWIHEPSDQVVSSAANV 401

  Fly   167 --TTTPTTTTRRTTRRPV---------ATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKP 220
              ..||.|..|...:..|         ||..|:.||.|...:.........|.|.| |...:.||
Mosquito   402 TLVVTPATAGRYYCKASVQGFAEVEADATVYLRGPPAISSPRQQYGAVHDSAQLEC-VALSIPKP 465

  Fly   221 ISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQVSTEPKASAIV 285
            ...|...:|..:.|......|:.|......||..|.:|.|.:.|.:..|.|.|.|..:   ..|.
Mosquito   466 RHVLWSFNGREINVSAEPNAAEYRALDSPIPNGVRSTLIIHHCQREHFGRYNCTVVND---YGID 527

  Fly   286 HLRIVEPKTELIGESTRH----VKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTE 346
            :|.|     |.:.:...:    :..||...:..:|...:            ..|.|.:||..:..
Mosquito   528 YLEI-----EFVSKGKPNLLPVIVLGSLGGITILIILVV------------IAICLCSRRNRKKH 575

  Fly   347 IERIDLPAEV------------------------------------PTTSTTTTTTTTTASTTTT 375
            :...|:..:|                                    ||.::..:|::|..||:..
Mosquito   576 LPPADVIPKVRVRANSPVACGSVQFRYSGDFSDSLSHLQCPKVGGGPTGTSGNSTSSTGNSTSNN 640

  Fly   376 TTSTTP-------ATPSTTATGSTEGATSSETL-------------------NGLVTITRS---- 410
            :....|       .:|.|......:.::||.::                   .|.:|:||.
Mosquito   641 SNGYVPYVNYARDYSPPTQHLMQFKASSSSNSIGNALTAKPPARPPANGQLPTGTMTLTRKRTPA 705

  Fly   411 ----------YILDAIS-----------------------------------QNDVSELG--AAA 428
                      .|..::|                                   ||.:..||  .||
Mosquito   706 APPDAGGALPSIQSSVSSIPNGLMSNPMQLPPPATANPAATPAPPPYSATRNQNCLLGLGLPPAA 770

  Fly   429 GVAVATETSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITTAATGDSAATAATTSA 493
            | ...|.|::|.||  ...:||.|.|.:|:..|||:..:.|...|.|  |..||..|.
Mosquito   771 G-GPTTGTNSAALL--ATGSSSPSSTQSGSLSLASSQLSQAPSIAGG--TVGTGQGAG------- 823

  Fly   494 WLTTMDAEAATTAATTTTTMLPSSSFIK 521
               ..:.:.....:.....:||||:.||
Mosquito   824 ---GREQQQQQPNSPPGQFILPSSNTIK 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	23/91 (25%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	23/85 (27%)
AgaP_AGAP000217	XP_310917.4	Ig	58..136	CDD:299845
		IG_like	59..153	CDD:214653
		C2-set_2	160..250	CDD:285423
		Ig_3	280..336	CDD:290638
		I-set	353..431	CDD:254352	15/81 (19%)
		IGc2	366..418	CDD:197706	10/51 (20%)
		Ig	435..531	CDD:299845	26/99 (26%)
		IG_like	442..525	CDD:214653	21/86 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810