DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and AgaP_AGAP010884

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_309810.4	Gene:	AgaP_AGAP010884 / 1271065	VectorBaseID:	AGAP010884	Length:	1951	Species:	Anopheles gambiae

Alignment Length:	766	Identity:	148/766 - (19%)
Similarity:	257/766 - (33%)	Gaps:	227/766 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 NGDQRLRLTAALEANLIMSNRNVQEQH-SYRITQ-----DNATSAASI----AP--------NGT 143
            :.|..:|:.   |.:|.:  :|:|:.: .|.:.:     .:..||.::    ||        |.|
Mosquito   745 SNDSSIRVE---EGSLFI--QNIQKSNEGYYLCEAINGIGSGLSAVTLITVQAPPEFVEKLRNQT 804

  Fly   144 AFGDAPSI---------PIGVAPATTTTIDPATTTPTTTTRRTTRRPV----ATTTLKPPPTIDD 195
            |....||:         |||:    ...::.....|.:..|.|.|..:    .|::|....|...
Mosquito   805 ARRGEPSVLQCEAKGEKPIGI----LWNMNNIRLDPKSDNRYTIREEILPNGVTSSLSIKRTERS 865

  Fly   196 YQTIISQAGTHAY----------------LPCNVKQLVKK----PISWLRMRDG------HIL-- 232
            ...:.:...|:|:                :|..:|.|.|.    .:||.:..||      :|:
Mosquito   866 DSALFTCMATNAFGSDDTSINMIIQEVPEMPYALKVLDKSGRTVQLSWAKPYDGNSPLKRYIIEF 930

  Fly   233 ---------TVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEG-----------TYECQVST 277
                     .:|:.....|.....|...:|.. :..|:.|...:.|           |.|...|.
Mosquito   931 KRSRGSWENDIDRVIVPGDTNEAQVQKLSPAT-TYNIRIVAENEIGVSDPSDVVTIITAEEAPSG 994

  Fly   278 EPKASAI-----VHLRI---VEPKTELIGESTRHVKAGSQVKLRCII-----------SQALEPP 323
            :|:|..:     ..||:   ..|:.|..|:...:.....|..|..:.           .:..|..
Mosquito   995 KPQAIKVEAINQATLRVSWKAPPRAEWNGDILGYYVGYKQTSLNTLYVYETVNYSPEGGEGKEHS 1059

  Fly   324 LFINWF--YNQKQIYLH--NR--RGWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPA 382
            |.||..  |.|..|.:.  |:  .|..::.|:.......|....:.|..||..|.|...:..:|
Mosquito  1060 LEINNLKTYTQYSIVIQAFNKVGAGPMSDEEKQYTAEGTPDQPPSDTMCTTLTSQTIRVSWVSP- 1123

  Fly   383 TPSTTATGSTEG----------------------ATSSETLNGLVTITRSYILDAISQNDVSELG 425
             |..:|.|..:|                      |:|...|:||...| :|.:..::.....:..
Mosquito  1124 -PLESANGVIKGYKVVYAPSDLWNNDKNKDYKKTASSDTVLHGLKKYT-NYTMQVLATTSGGDGV 1186

  Fly   426 AAAGVAVATETSTAQLLTEVEATSSTSGT--------STGAGLLASTSAAYAAG----------- 471
            .:|.:...||....:..|.|:|...:.|:        :...||:...:....:|
Mosquito  1187 RSAPIHCQTEQDVPEAPTAVKALVMSEGSIFVSWQPPAQPNGLILQYTVYIKSGDQEPKSFKVPS 1251

  Fly   472 -----AAAGI-------------TTAATGDSAATAAT-----TSAWLTTMDAE------------ 501
                 .|:|:             ||...|.|:.|.:.     ..|.:.:.|.:
Mosquito  1252 YQINYEASGLEKNQKYEFWVTASTTIGEGQSSKTLSAMPSDKVPAKIASFDDKFTATFKEDAKLP 1316

  Fly   502 --AATTAATTTTTMLPSSSF-----IKQITTASLIIPAVVKLDSGNYTCSPSNSAPRTIVLHVL- 558
              |..:.|...|..:....|     |:|:...||.|..|::.|:|:|||:..||..:..:.|.|
Mosquito  1317 CLAVGSPAPEITWKIKGVEFVPNERIRQLPEGSLFIKDVIRQDAGDYTCTAENSIAKDSITHRLI 1381

  Fly   559 ------NGEYSASAIKSGSVS------WSALIGCHGY-LHWR----NVSTLLTLLWIIKFALARD 606
                  :.:.:.:|..:.|:|      .|......|| ||::    ...|:...|...|:.:.:.
Mosquito  1382 VLAPPQSPQLTLTATTTDSLSVKLKPHESDTAPLQGYTLHYKPEFGEWETIDVALEAPKYTIEKL 1446

  Fly   607 ICQPNATSKATTRTSLLRAGDGATADV--TRETGPK----SGASFHRVSSS 651
            .|.......||...|:   |.|..:|:  ||..|.|    ..:.|..|||:
Mosquito  1447 YCGSRYQVYATAYNSI---GAGEPSDILNTRTKGSKPLLPEKSRFIEVSSN 1494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	24/144 (17%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	25/141 (18%)
AgaP_AGAP010884	XP_309810.4	Ig	16..110	CDD:299845
		IG_like	35..106	CDD:214653
		I-set	231..320	CDD:254352
		Ig	248..317	CDD:143165
		I-set	328..402	CDD:254352
		IGc2	338..390	CDD:197706
		IG_like	417..504	CDD:214653
		IGc2	423..494	CDD:197706
		I-set	510..593	CDD:254352
		IGc2	521..584	CDD:197706
		Ig	619..689	CDD:143165
		I-set	696..788	CDD:254352	9/47 (19%)
		Ig	715..788	CDD:299845	9/47 (19%)
		I-set	794..889	CDD:254352	17/98 (17%)
		Ig	808..896	CDD:299845	14/91 (15%)
		FN3	893..987	CDD:238020	16/94 (17%)
		FN3	994..1094	CDD:238020	19/99 (19%)
		FN3	1102..1195	CDD:238020	18/95 (19%)
		FN3	1200..1288	CDD:238020	14/87 (16%)
		Ig	1315..1382	CDD:299845	19/66 (29%)
		FN3	1386..1475	CDD:238020	19/91 (21%)
		FN3	1480..1560	CDD:238020	4/15 (27%)
		Dscam_C	1858..1949	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900