DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Fgfrl1

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_473412.1	Gene:	Fgfrl1 / 116701	MGIID:	2150920	Length:	529	Species:	Mus musculus

Alignment Length:	548	Identity:	100/548 - (18%)
Similarity:	149/548 - (27%)	Gaps:	217/548 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 ITQDNATSAASIAPNGTAFGDAPSIPIGVAPATTTTIDPATTTPTTTTRRTTRRPVATTTLKPPP 191
            |..|.:....|..|.|::.|...       ||:.....|..|.|:...||...|||
Mouse   112 IMDDISPGKESPGPGGSSGGQED-------PASQQWARPRFTQPSKMRRRVIARPV--------- 160

  Fly   192 TIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERW 256
                        |:...|.|......:..|.|  |:|...||..:.:           ....::|
Mouse   161 ------------GSSVRLKCVASGHPRPDIMW--MKDDQTLTHLEAS-----------EHRKKKW 200

  Fly   257 SLQIKYVQLKDEGTYECQVSTEPKASAIVHLRIVEPKTELIGESTRHVKAGSQVKLRCIISQALE 321
            :|.:|.::.:|.|.|.|:||.                           |||:
Mouse   201 TLSLKNLKPEDSGKYTCRVSN---------------------------KAGA------------- 225

  Fly   322 PPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATPST 386
                ||..|                  ::|:...  |.|....|.|...:||.....||.
Mouse   226 ----INATY------------------KVDVIQR--TRSKPVLTGTHPVNTTVDFGGTTS----- 261

  Fly   387 TATGSTEGATSSETLNGLVTITRSYILDAISQNDVSELGAAAGVAVATETSTAQLLTEVEATSST 451
                                      .....::||..:              .|.|..||
Mouse   262 --------------------------FQCKVRSDVKPV--------------IQWLKRVE----- 281

  Fly   452 SGTSTGAGLLASTSAAYAAGAAAGITTAATGDSAATAATTSAWLTTMDAEAATTAATTTTTMLPS 516
                            |.:......|....|.......|...|                  ..|.
Mouse   282 ----------------YGSEGRHNSTIDVGGQKFVVLPTGDVW------------------SRPD 312

  Fly   517 SSFIKQITTASLIIPAVVKLDSGNYTCSPSNS---APRTIVLHVL-----NGEYSASAIKSGSVS 573
            .|::.:     |:|....:.|:|.|.|..:|:   :.|:..|.||     .|...||:..|.|:.
Mouse   313 GSYLNK-----LLISRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPMASSSSSTSLP 372

  Fly   574 WSALIGCHGYLHWRNVSTLLT-LLWIIKFALARDICQPNAT----SKATTRTSLLRAGD----GA 629
            |..:||    :....|..|.| |||:.:  ..:..|.|.:|    ......||..|:||    ..
Mouse   373 WPVVIG----IPAGAVFILGTVLLWLCQ--TKKKPCAPASTLPVPGHRPPGTSRERSGDKDLPSL 431

  Fly   630 TADVTRETGPKSGASFHRVSSSISATKV 657
            ...:..|.|..........|.|.:..|:
Mouse   432 AVGICEEHGSAMAPQHILASGSTAGPKL 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	18/91 (20%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	18/85 (21%)
Fgfrl1	NP_473412.1	I-set	29..112	CDD:369462	100/548 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..151		9/41 (22%)
		Ig2_FGFRL1-like	153..234	CDD:143264	29/176 (16%)
		Ig	257..351	CDD:386229	24/182 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..427		6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910