DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and mxra5

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_002941051.4	Gene:	mxra5 / 100495231	XenbaseID:	XB-GENE-923372	Length:	2851	Species:	Xenopus tropicalis

Alignment Length:	778	Identity:	153/778 - (19%)
Similarity:	253/778 - (32%)	Gaps:	257/778 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PATTQMAQTLDKASAFRPTMAAALDAAAPNRSSNNVAI--------NNISNNG------------ 98
            |:||    |......|||      ....|:|.:....|        |.::|||
Frog  1687 PSTT----TTTVVPLFRP------KPMTPSRFNLGQRISPYYRPAGNTLNNNGKDIVARIPYQGN 1741

  Fly    99 --------------DQRLRLTAALE----ANLIMSNRNVQEQHSY----RITQDNATSAASIAPN 141
                          .:.:..||.|:    .||:..:.|  ::::|    :.|..:|...|::||
Frog  1742 PYYLNPRFHYRFNRTKPIIFTATLKPPIPTNLVPDSAN--KKNTYVSAAKTTISSAIIKATVAP- 1803

  Fly   142 GTAFGDAPSIPIGVAPAT------TTTIDPATTTPTTTT-------------------------- 174
                  .|.||: ..|||      ||.....|.||.:::
Frog  1804 ------LPVIPV-TKPATQKQMQLTTPYIVHTQTPKSSSTIQLNRYFNHINNKPSIVEGAKLTNL 1861

  Fly   175 ----RRTTRRPVATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVD 235
                ...|:||..   :||..|....|::.....|.|.:||......|..|:|.::..|.:::.:
Frog  1862 NEIQSSVTQRPQG---IKPRITTTGLQSLSVPFETDAVIPCETFGDPKPSITWTKVATGAVMSKN 1923

  Fly   236 QTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQVSTEPKASAI-VHLRIVEPKTELIGE 299
            ...    ||::.:     |..:|.|:.:||:|.|.|.|....:.....: |.|.:|..:..::|.
Frog  1924 TRM----QRYEVL-----ENGTLSIQKLQLQDHGQYVCTAQNQHGIDKMYVTLTVVVQQPRILGS 1979

  Fly   300 STRHVKA--GSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTSTT 362
            ..:.|..  |..:.:.|..|..  |.:.|:|.:..::|.   |....|| .||.|..........
Frog  1980 RYKDVTVYIGDTISMDCPASGV--PSVHISWIFPDRKII---RTVSATE-SRIMLHENGTLIIKE 2038

  Fly   363 TTTT---------TTTASTTTTTTS------------------TTPATPSTTATGSTEGATS--- 397
            ||.|         :..|...:.|..                  |.|...|.....|.:||.|
Frog  2039 TTFTDRGIFKCVASNVAGADSLTVRLHIAALPPIIKQEKQENITLPHGHSVYIHCSAKGAPSPSI 2103

  Fly   398 ------------SETLNGLVTI--TRSYILDAISQNDVSELGAAAGVAVATETSTAQLLTEVEAT 448
                        |:.:||.|.:  ..:..:.::||.|..:....|...|.....|  ::.:|:..
Frog  2104 RWVLFDGTQVRTSQFVNGNVFVFPNGTLYIRSLSQKDTGKYECVATNIVGAARRT--IMLDVKKL 2166

  Fly   449 SSTSGTSTGAGLLASTSAAYAAGAAAGITTAATGDSAATAATTSAWLTTMDAEAATTAATTTTTM 513
            :|.                      |.||.::...:..|..:|    ..:|..||..........
Frog  2167 ASN----------------------AKITASSPQKTDVTYGST----LRLDCSAAGDPWPRILWR 2205

  Fly   514 LPS----------SSFIKQITTASLIIPAVVKLDSGNYTCSPSNSAPRTIVLHVLN--------- 559
            |||          .|.||..:..:|:|.:|.:.|:|:|.|...|......|:..:|
Frog  2206 LPSKRVVDSFFSFDSRIKTYSNGTLLIYSVTEKDAGDYLCMARNKLGDDYVVLKVNVMMKPAKIQ 2270

  Fly   560 ------------GEYSASAIKSG----SVSWSALIGCHGYLHWRNVSTLLTLLWIIKFALARDIC 608
                        |:.....|.:|    .:|||...|                      ::..:|.
Frog  2271 YKNEVDHKVMYGGDLKVDCIATGVPNPEISWSLPDG----------------------SMINNIM 2313

  Fly   609 QPNATSKATTRTSLLRAGDGATADV-TRETGP-------KSGASFHRVSSSISATK-VAEDKT 662
            |.:.:...|.|..:...|.....:| .:|.|.       :.|....|||..:.|.| |.::||
Frog  2314 QSDDSGTRTRRYVVFNNGTLYFNEVGLKEEGDYTCYAINQIGQDEMRVSVKVVAEKAVIKNKT 2376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	22/92 (24%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	21/86 (24%)
mxra5	XP_002941051.4	LRRNT	44..75	CDD:214470
		leucine-rich repeat	55..72	CDD:275380
		leucine-rich repeat	74..97	CDD:275380
		PPP1R42	82..238	CDD:411060
		LRR_8	96..156	CDD:404697
		leucine-rich repeat	98..121	CDD:275380
		leucine-rich repeat	122..145	CDD:275380
		leucine-rich repeat	146..169	CDD:275380
		leucine-rich repeat	170..201	CDD:275380
		leucine-rich repeat	202..225	CDD:275380
		LRRCT	234..293	CDD:214507
		IG	511..584	CDD:214652
		IG	598..680	CDD:214652
		Herpes_BLLF1	<1269..1567	CDD:282904
		Ig	1895..1959	CDD:409353	18/72 (25%)
		Ig strand B	1895..1899	CDD:409353	1/3 (33%)
		Ig strand C	1908..1912	CDD:409353	1/3 (33%)
		Ig strand E	1935..1939	CDD:409353	1/3 (33%)
		Ig strand F	1949..1954	CDD:409353	2/4 (50%)
		Ig	1989..2066	CDD:416386	18/82 (22%)
		Ig strand B	1991..1999	CDD:409353	1/7 (14%)
		Ig strand C	2005..2010	CDD:409353	2/4 (50%)
		Ig strand C'	2013..2015	CDD:409353	0/1 (0%)
		Ig strand D	2025..2029	CDD:409353	2/3 (67%)
		Ig strand E	2032..2036	CDD:409353	0/3 (0%)
		Ig strand F	2046..2053	CDD:409353	0/6 (0%)
		Ig strand G	2056..2066	CDD:409353	1/9 (11%)
		Ig	2072..2163	CDD:416386	17/92 (18%)
		Ig strand A	2072..2075	CDD:409353	0/2 (0%)
		Ig strand A'	2080..2083	CDD:409353	0/2 (0%)
		Ig strand B	2089..2096	CDD:409353	1/6 (17%)
		Ig strand C	2102..2108	CDD:409353	0/5 (0%)
		Ig strand C'	2110..2112	CDD:409353	0/1 (0%)
		Ig strand D	2122..2126	CDD:409353	1/3 (33%)
		Ig strand E	2129..2134	CDD:409353	0/4 (0%)
		Ig strand F	2142..2150	CDD:409353	1/7 (14%)
		Ig strand G	2153..2163	CDD:409353	1/11 (9%)
		Ig	2172..2252	CDD:416386	21/83 (25%)
		Ig strand A	2172..2175	CDD:409353	2/2 (100%)
		Ig strand A'	2179..2182	CDD:409353	0/2 (0%)
		Ig strand B	2188..2195	CDD:409353	1/6 (17%)
		Ig strand C	2201..2210	CDD:409353	3/8 (38%)
		Ig strand C'	2212..2214	CDD:409353	0/1 (0%)
		Ig strand D	2221..2225	CDD:409353	2/3 (67%)
		Ig strand E	2228..2233	CDD:409353	1/4 (25%)
		Ig strand F	2241..2249	CDD:409353	3/7 (43%)
		Ig	2279..2365	CDD:416386	19/107 (18%)
		Ig strand B	2284..2292	CDD:409353	1/7 (14%)
		Ig strand C	2298..2303	CDD:409353	2/4 (50%)
		Ig strand C'	2306..2308	CDD:409353	1/23 (4%)
		Ig strand D	2324..2328	CDD:409353	1/3 (33%)
		Ig strand E	2331..2335	CDD:409353	1/3 (33%)
		Ig strand F	2345..2352	CDD:409353	0/6 (0%)
		Ig strand G	2355..2365	CDD:409353	4/9 (44%)
		Ig strand A	2369..2372	CDD:409353	1/2 (50%)
		Ig strand A'	2377..2381	CDD:409353	153/778 (20%)
		I-set	2382..2459	CDD:400151
		Ig strand B	2387..2396	CDD:409353
		Ig strand C	2401..2406	CDD:409353
		Ig strand C'	2409..2411	CDD:409353
		Ig strand D	2419..2422	CDD:409353
		Ig strand E	2425..2432	CDD:409353
		Ig strand F	2438..2446	CDD:409353
		Ig strand G	2449..2459	CDD:409353
Ig	2475..2559	CDD:416386
Ig strand A'	2476..2479	CDD:409353
Ig strand B	2485..2493	CDD:409353
Ig strand C	2499..2504	CDD:409353
Ig strand C'	2507..2509	CDD:409353
Ig strand D	2518..2522	CDD:409353
Ig strand E	2525..2529	CDD:409353
Ig strand F	2539..2546	CDD:409353
Ig strand G	2549..2559	CDD:409353
Ig_3	2565..2643	CDD:404760
Ig strand A'	2574..2577	CDD:409353
Ig strand B	2583..2590	CDD:409353
Ig strand C	2596..2608	CDD:409353
Ig strand C'	2611..2613	CDD:409353
Ig strand D	2617..2620	CDD:409353
Ig strand E	2622..2626	CDD:409353
Ig strand F	2635..2643	CDD:409353
Ig_3	2659..2737	CDD:404760
Ig strand B	2678..2682	CDD:409353
Ig strand C	2691..2695	CDD:409353
Ig strand E	2717..2721	CDD:409353
Ig strand F	2731..2736	CDD:409353
Ig_3	2755..2837	CDD:404760
Ig strand A	2755..2759	CDD:409353
Ig strand A'	2764..2768	CDD:409353
Ig strand B	2772..2781	CDD:409353
Ig strand C	2787..2796	CDD:409353
Ig strand C'	2802..2805	CDD:409353
Ig strand E	2816..2822	CDD:409353
Ig strand F	2829..2837	CDD:409353
Ig strand G	2842..2850	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910