DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and lrig2

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_002932176.2	Gene:	lrig2 / 100494845	XenbaseID:	XB-GENE-922899	Length:	1078	Species:	Xenopus tropicalis

Alignment Length:	359	Identity:	69/359 - (19%)
Similarity:	109/359 - (30%)	Gaps:	133/359 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 TMAA--ALDAAAPNRSSNNVAINNISNNGDQRLRLTAALEANLIMSNRNV----QEQHSYRITQD 130
            ||.|  .||:......||| ||.::..||...::|     ..||::..|:    |.:.......|
Frog   385 TMKAFTGLDSLQHLDLSNN-AILSVQENGFSFMKL-----QELILNTSNLLCDCQLKWFPHWLND 443

  Fly   131 NA----TSAASIAPNGTAFGDAP-----------SIP---IGVAPATTTTIDPATTTPTTTTRRT 177
            |.    .:.:...||..| |.:|           :.|   |.:.|.||..:.....:.|.....:
Frog   444 NGFHQFVNVSCAHPNWLA-GRSPLSVDAEDFICDNFPKPQIKLQPETTVALKGMNVSLTCAAASS 507

  Fly   178 TRRPVATTTLKPPPTIDD-----------------------------------YQTIIS------ 201
            :..|::|...|....:.|                                   ||.:|:
Frog   508 SDTPMSTAWRKDGEVLYDAEVENFARYHKHGIELIEYITVLHLFNVNFTDEGKYQCVITNHFGSN 572

  Fly   202 ------------------------QAGTHAYLPCNVKQLVKKPISWLRMRDG------------H 230
                                    :.|..|.|.|..:......|:|  .:||            |
Frog   573 YSSKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPPPQIAW--QKDGGTDFPAARERRMH 635

  Fly   231 ILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQV-STEPKASAIVHLRIVEPKT 294
            ::..|:..||.:                    |:::|.|.|.|.. :.....||.|.|.::|..:
Frog   636 VMPEDEVLFIVN--------------------VKIEDMGLYSCTAQNAAGSISANVTLTVLETPS 680

  Fly   295 ELIGESTRHVKAGSQVKLRCIISQALEPPLFINW 328
            .:.....|.|..|....|.||...:..|.|  ||
Frog   681 FVRPLEDRTVARGETAVLHCIAGGSPAPRL--NW 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	23/134 (17%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	21/98 (21%)
lrig2	XP_002932176.2	PRK15370	<37..>165	CDD:185268
		leucine-rich repeat	37..56	CDD:275380
		leucine-rich repeat	58..81	CDD:275380
		leucine-rich repeat	82..104	CDD:275380
		leucine-rich repeat	105..128	CDD:275378
		LRR	127..>384	CDD:227223
		leucine-rich repeat	129..148	CDD:275380
		leucine-rich repeat	152..175	CDD:275380
		leucine-rich repeat	176..199	CDD:275380
		leucine-rich repeat	200..223	CDD:275380
		leucine-rich repeat	224..247	CDD:275380
		leucine-rich repeat	248..271	CDD:275380
		leucine-rich repeat	272..295	CDD:275380
		leucine-rich repeat	296..319	CDD:275380
		leucine-rich repeat	320..343	CDD:275380
		leucine-rich repeat	344..368	CDD:275380
		LRR_8	370..429	CDD:338972	16/49 (33%)
		leucine-rich repeat	371..394	CDD:275380	4/8 (50%)
		leucine-rich repeat	395..417	CDD:275380	7/22 (32%)
		LRRCT	428..476	CDD:214507	8/48 (17%)
		Ig	485..581	CDD:386229	11/95 (12%)
		Ig_1	602..676	CDD:143240	20/95 (21%)
		I-set	679..766	CDD:369462	10/36 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910