DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and lrig1

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_002938412.1	Gene:	lrig1 / 100491453	XenbaseID:	XB-GENE-494193	Length:	1043	Species:	Xenopus tropicalis

Alignment Length:	534	Identity:	111/534 - (20%)
Similarity:	182/534 - (34%)	Gaps:	155/534 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RRLILLALLICLPAIRGQAEETSILNSNGTNGRAF-----QRTQSRREALIPATTQMAQTLDKAS 67
            |||.......|  |..|....|||.:   ...|:|     .:.|.|.:   |.|| || .|.||.
Frog   445 RRLQTKVKASC--AHPGSLNNTSIFS---VPPRSFVCDDLPKPQIRVQ---PETT-MA-VLGKAI 499

  Fly    68 AFRPTMAAALDAAAP--------NRSSNNVAINNISNNGDQRLRLTAALEANLIMSNRNVQEQHS 124
            .|  |.:||..:.:|        |...:|..:.|.::..::...:|   |...|:..||:...|.
Frog   500 RF--TCSAASSSPSPMTFAWKKDNEILHNAEVENFASGTEREGEVT---EYTTILHLRNLTFAHE 559

  Fly   125 YR----ITQDNATSAASIAPNGTAFGDAPSIPIGVAPATTTTIDPATTTPTTTTRRTTRRPVATT 185
            .|    ||.|          .|.::.....:.:.|.|:       ...||..:|.|
Frog   560 GRYQCIITND----------FGPSYSSKARLTVNVLPS-------FIKTPRDSTIR--------- 598

  Fly   186 TLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDG------------HILTVDQTT 238
                             |||.|.|.|.........|:|  .:||            |::..|...
Frog   599 -----------------AGTRARLECAADGHPTPEIAW--QKDGGTDFPAARERRMHVMPDDDVF 644

  Fly   239 FIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQV-STEPKASAIVHLRIVEPKTELIGESTR 302
            ||.|                    |:::|.|.|.|.. ::....||...|.::|....:.....|
Frog   645 FIMD--------------------VKIEDMGVYSCTAQNSAGSVSANATLTVLEMPFLVHPLEDR 689

  Fly   303 HVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTSTTTTTTT 367
            .|..|:.:.|:|..|.:  ||..|.|....:.:.:..|..: |...::.:..:|         .:
Frog   690 VVSTGATLALQCKASGS--PPPRITWLKGDEPLVMTERHHY-TPGNQLLIIRQV---------MS 742

  Fly   368 TTASTTTTTTSTTPATP---STTATGSTEGAT-SSETLNGLVT---ITRSYILDAISQNDVSELG 425
            ..|...|...|.|..|.   |..:..||.|.. ..:.:.|::|   ||.:.:...:       |.
Frog   743 EDAGKYTCEMSNTLGTERAYSHVSIASTAGCQGEKDKMEGMMTFGIITIAVVCSIV-------LT 800

  Fly   426 AAAGVAVATETSTAQLLTEVEATSSTSGT---------STGAGLLASTSAAYAAGAAAGIT---- 477
            :...|.:..:|   :..:||.:.::|..|         .:..||.:|..:......|..:.
Frog   801 SLVWVCIIYQT---RKKSEVYSVTNTDETIVPPDVPSYLSSQGLCSSDGSVNPEAEACSVAYRQP 862

  Fly   478 ---TAATGDSAATA 488
               |.::|::..||
Frog   863 RLCTCSSGEACKTA 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	23/104 (22%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	22/98 (22%)
lrig1	XP_002938412.1	LRRNT	28..59	CDD:214470
		leucine-rich repeat	57..80	CDD:275378
		PLN00113	<58..>370	CDD:215061
		leucine-rich repeat	104..127	CDD:275380
		leucine-rich repeat	128..151	CDD:275380
		leucine-rich repeat	152..199	CDD:275380
		leucine-rich repeat	200..223	CDD:275380
		leucine-rich repeat	224..247	CDD:275380
		leucine-rich repeat	248..295	CDD:275380
		leucine-rich repeat	272..292	CDD:275380
		leucine-rich repeat	296..319	CDD:275380
		leucine-rich repeat	320..343	CDD:275380
		LRR_8	343..405	CDD:338972
		leucine-rich repeat	344..370	CDD:275380
		leucine-rich repeat	371..394	CDD:275380
		leucine-rich repeat	395..413	CDD:275380
		LRRCT	429..477	CDD:214507	11/36 (31%)
		leucine-rich repeat	445..471	CDD:275380	9/30 (30%)
		IG	488..582	CDD:214652	27/110 (25%)
		Ig_1	603..677	CDD:143240	20/95 (21%)
		I-set	680..759	CDD:369462	17/90 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910