DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and map3k1

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_012822348.1	Gene:	map3k1 / 100490504	XenbaseID:	XB-GENE-1008434	Length:	1445	Species:	Xenopus tropicalis

Alignment Length:	691	Identity:	128/691 - (18%)
Similarity:	229/691 - (33%)	Gaps:	210/691 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PAIRGQAEETSILNS------NGTNGRAFQRTQSR------REALIPATTQMA---QTLDKASAF 69
            ||...:.||.|..:|      |....|..|:...|      ||.| .||...|   :.|::.|..
Frog    86 PAAGSEPEEPSAAHSSCRDMENKETLRGLQKMDDRPEERMIREKL-KATCMPAWKHEWLERKSRR 149

  Fly    70 RPTMAAALDAAAPNRSSNNVAINNISNNGDQRLRLTAALEANLIMSNRNVQEQHSYRITQDNATS 134
            .|.:...:...|               .|.:..: ..::|.:|    ..:...|..|.:...::|
Frog   150 GPVVVKPIPVKA---------------EGSETFK-ADSVEGSL----NGLSHVHKGRRSPSPSSS 194

  Fly   135 AASIAPNGTAFGDAPSIP-IGVAPATTTTIDPATTTPTT------TTRRTTRR--PVATTTLKPP 190
            ::|   :.:...::|.:. .|::|..:..:.|....|:.      :...|:||  .|....|
Frog   195 SSS---SKSTKPESPGLKRRGLSPVPSGRVTPPRRAPSPDGFSPFSPEETSRRVHKVMRARL--- 253

  Fly   191 PTIDDYQTIISQAGTHAYL-----PCNVKQLVKKP--------------------ISWLRMRDGH 230
                   .::.|.|.:::|     |.|..::...|                    :..|...|..
Frog   254 -------YLLQQIGPNSFLIGGDSPDNKYRVFIGPQACSCGRGTFCIHLLFVMLRVFQLEPSDTM 311

  Fly   231 ILTVDQTTFIADQRFQSVFSPN------PERWSLQIKYVQLKDEGTYECQVSTEPKASAIVHLRI 289
            :.......|..:..||...|..      |.|.::| |:|. :...::....||...:|:...::.
Frog   312 LWRKALKNFEVESLFQKYHSRRSSRIKAPSRNTIQ-KFVS-RMSSSHTLSSSTTSTSSSDTSMKD 374

  Fly   290 VEPK---TELIG----ESTRHVKAGSQVKL--RCIISQA------LEP---PLFINWFYNQKQIY 336
            .|.:   ..|:|    ||....:.|.:.||  .|:...|      .||   ||.
Frog   375 EEEQMCPICLLGMLDEESLTVCEEGCRNKLHHHCMSIWAEECRRNREPLICPLC----------- 428

  Fly   337 LHNRRGWRT-EIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATSSET 400
               |..||: :...::||.  |..|..........|.....|..:...|..|:...|.
Frog   429 ---RAKWRSQDFNSVELPG--PVDSPPILRAVQQQSLQQLPTPGSQRRPQDTSLNLTH------- 481

  Fly   401 LNGLVTITRSY---------------ILDAISQN-DVSELGAAAGVAVATETSTAQLLTEVEATS 449
             .|:..|..:|               :....|:| ::.|:...   .::.:.|.|.||...|:|.
Frog   482 -YGVQNIPFAYKDMAEPWIQVFGMELVSCLFSRNWNIREMALR---RLSHDVSGALLLANGESTG 542

  Fly   450 ---STSGTSTGAGLLASTSAAYAAGAAAGITTAATGDSAATAATTSAWLTTMDA--EAATTAATT 509
               ::|||::|..|.|::.::         .:..:||....|..:...:...|.  :....|..|
Frog   543 NSCNSSGTTSGTSLNAASGSS---------QSTISGDVVVEACCSVLSMVCADPVYKVYVAALKT 598

  Fly   510 TTTML---PSSSFIKQITTASLIIPAV----VKLDSGNYTCSPSNSAPRTI----VLHVLNGEYS 563
            ...||   |..:..::.....|:.|.|    ||       |:.:||....:    :|.:..|:..
Frog   599 LRAMLVYTPCHTITERKKLQRLLNPVVETILVK-------CADANSRTSQLSVSTLLELCKGQAG 656

  Fly   564 ASAI-----KSGSV--------------------SWSALIG 579
            ..|:     ||||:                    :|.:|:|
Frog   657 ELAVGREILKSGSIGIGGVDYVLHCILATQAEPNNWQSLLG 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	20/122 (16%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	19/116 (16%)
map3k1	XP_012822348.1	RING-CH-C4HC3_ZSWM2	377..432	CDD:319408	14/68 (21%)
		RING-CH finger (C4HC3-type)	380..428	CDD:319408	12/47 (26%)
		STKc_MEKK1	1175..1442	CDD:270800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900