DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Kirrel2

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_038957463.1	Gene:	Kirrel2 / 100359836	RGDID:	1308456	Length:	711	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	95/469 - (20%)
Similarity:	149/469 - (31%)	Gaps:	142/469 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 PPTIDDYQTIISQAGTHAYLPCNV---KQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSP 251
            |..:...:.::...|..|.|||.:   :.||:    |  .:||..|
  Rat    32 PHFLQQPEDMVVLLGQEARLPCALGAYRGLVQ----W--TKDGLAL------------------- 71

  Fly   252 NPER----WS--------------LQIKYVQLKDEGTYECQVSTEPKAS--AIVHLRIVEPKTEL 296
            ..||    ||              |.||.|:|:||.:||||.|.....|  |.:|:.:.....::
  Rat    72 GGERDLPGWSRYWISGNSASGQHDLHIKPVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQV 136

  Fly   297 IGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTST 361
            :|..:..:.||....|.|.......|...:.||          |.|.|.:             .|
  Rat   137 LGGPSVSLVAGVPGNLTCRSRGDARPAPELLWF----------RDGIRLD-------------GT 178

  Fly   362 TTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATSSETLNGLVTITRSYILDAISQNDVS-ELG 425
            :....|.....|.|..:|...|||:...|:|           |:...||..|.......|: .|.
  Rat   179 SFHQITLRDKATGTVENTLFLTPSSQDDGAT-----------LICRARSQALPTGRDTAVTLSLQ 232

  Fly   426 AAAGVAVATETSTAQ------LLTEVEATSSTSG---TSTGAGLLASTSAAYAAGAAAGITTAAT 481
            ....|.::.|..|||      .|.:..|....:|   ...|:.:|.:........|.|...|...
  Rat   233 YPPMVTLSAEPQTAQEGEKVTFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADATFLTEPV 297

  Fly   482 GDSAATAATTSAWLTTMD------------------AEAATTAATTTTTMLPSSSFIK----QIT 524
            ....:.|..::...|.::                  .:.|:.:.......||..|:.:    |:.
  Rat   298 SCEVSNAVGSANRSTALEVLYGPILQAKPKPVSVDVGKDASFSCVWRGNPLPRISWTRLGGSQVL 362

  Fly   525 TA--SLIIPAVVKLDSGNYTCSPS-----------------NSAPRTIVLH----VLNGEYSASA 566
            ::  :|.:|:|...|:|:|.|...                 |:.|....||    .|.|......
  Rat   363 SSGPTLRLPSVALEDAGDYVCRAEPRRTGVGGGTAQARLTVNAPPVVTALHPAPAFLRGPARLQC 427

  Fly   567 I-----KSGSVSWS 575
            :     ...||.||
  Rat   428 VVFASPAPDSVVWS 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	30/114 (26%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	30/108 (28%)
Kirrel2	XP_038957463.1	IG_like	38..127	CDD:214653	29/113 (26%)
		Ig strand A'	40..44	CDD:409353	0/3 (0%)
		Ig strand B	48..57	CDD:409353	4/8 (50%)
		Ig strand C	62..66	CDD:409353	2/9 (22%)
		Ig strand D	75..85	CDD:409353	3/9 (33%)
		Ig strand E	88..100	CDD:409353	2/11 (18%)
		Ig strand F	107..115	CDD:409353	4/7 (57%)
		Ig strand G	117..127	CDD:409353	2/9 (22%)
		Ig	133..231	CDD:416386	26/131 (20%)
		Ig strand A	134..137	CDD:409353	0/2 (0%)
		Ig strand A'	140..144	CDD:409353	0/3 (0%)
		Ig strand B	151..158	CDD:409353	2/6 (33%)
		Ig strand C	164..169	CDD:409353	0/4 (0%)
		Ig strand C'	172..174	CDD:409353	1/1 (100%)
		Ig strand D	177..184	CDD:409353	1/6 (17%)
		Ig strand E	191..199	CDD:409353	2/7 (29%)
		Ig strand F	208..216	CDD:409353	2/18 (11%)
		Ig strand G	222..228	CDD:409353	0/5 (0%)
		Ig_3	234..303	CDD:404760	13/68 (19%)
		Ig strand B	252..256	CDD:409353	0/3 (0%)
		Ig strand C	266..270	CDD:409353	1/3 (33%)
		Ig strand E	283..286	CDD:409353	0/2 (0%)
		Ig strand F	292..301	CDD:409353	1/8 (13%)
		Ig strand G	309..312	CDD:409353	0/2 (0%)
		Ig	326..403	CDD:416386	12/76 (16%)
		Ig strand A'	327..332	CDD:409353	0/4 (0%)
		Ig strand B	335..344	CDD:409353	1/8 (13%)
		Ig strand C	350..354	CDD:409353	1/3 (33%)
		Ig strand C'	357..359	CDD:409353	0/1 (0%)
		Ig strand D	362..365	CDD:409353	0/2 (0%)
		Ig strand E	366..371	CDD:409353	1/4 (25%)
		Ig strand F	379..387	CDD:409353	3/7 (43%)
		Ig strand G	393..403	CDD:409353	0/9 (0%)
		Ig	405..509	CDD:416386	9/37 (24%)
		Ig strand A	406..410	CDD:409353	1/3 (33%)
		Ig strand A'	412..415	CDD:409353	2/2 (100%)
		Ig strand B	423..430	CDD:409353	0/6 (0%)
		Ig strand C	437..442	CDD:409353	4/5 (80%)
		Ig strand C'	444..447	CDD:409353
		Ig strand D	455..462	CDD:409353
		Ig strand E	472..479	CDD:409353
		Ig strand F	490..497	CDD:409353
		Ig strand G	500..507	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900