DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and lrit3b

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_009305418.1	Gene:	lrit3b / 100144406	ZFINID:	ZDB-GENE-070424-130	Length:	487	Species:	Danio rerio

Alignment Length:	345	Identity:	70/345 - (20%)
Similarity:	108/345 - (31%)	Gaps:	82/345 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LAKMPRRLILLALLICLP--AIRGQAEETSILNSNGTNGRAFQRTQSRREALIPATTQMAQTLDK 65
            |.|.|   .|.|:.|.||  .::.:.|.||:       .|.|:...|    .:|....:..|.:.
Zfish    73 LCKNP---ALTAIPIDLPNDTVKFRLERTSV-------SRIFRGAFS----AMPELLYLWLTYNS 123

  Fly    66 ASAFRPTMAAALDAAAPNRSSNNVAIN---------------NISNNGDQRLRLTAA-------- 107
            .|...|.....|.:....|...|:...               .:.||...|:.|.|.
Zfish   124 ISVLHPRSFTNLSSLHELRLDGNLLSTFPWEGLRDMPRLRTLGLHNNRLARIPLLAVRYLRNVTY 188

  Fly   108 --------------LEANLIMSNRNVQEQHSYRI-TQDNATSAASIAPNGTAFGDAPSIPIGVAP 157
                          |.|..:.|:.| |.|.|:.: .|||.................|...:.:..
Zfish   189 LDLSSNRLSTLANDLTALWLFSDSN-QTQRSFVLGLQDNPWVCDCRLSTLLDISRGPESSLVLLD 252

  Fly   158 ATTTTIDP---ATTTPTTTTRRTTRRP-VATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVK 218
            ...|..:|   |.....:......||| |.|:..|          |.:..|:...|.|.......
Zfish   253 RFLTCSEPLDLAGVPFQSVELSRCRRPYVVTSATK----------ITALLGSTVLLRCEATGHPT 307

  Fly   219 KPISWLRMRDGHILT---VDQTTFIAD-QRF-QSVFSPNPE------RWS-LQIKYVQLKDEGTY 271
            ..:.|::....::..   ..||....| :|| :.:|....|      ||| :.:..:...|.|.|
Zfish   308 PALMWIKSAKRNLYNQGCCKQTQSSLDTERFPKKLFGYVQESPRVGVRWSVVSLNGISYSDAGEY 372

  Fly   272 ECQVSTEPKAS-AIVHLRIV 290
            .|:.......| |:|.|.:|
Zfish   373 RCRAQNMAGISEAVVSLNVV 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	23/104 (22%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	22/98 (22%)
lrit3b	XP_009305418.1	LRRNT	51..92	CDD:214470	8/21 (38%)
		leucine-rich repeat	69..89	CDD:275380	8/18 (44%)
		LRR_8	112..172	CDD:290566	9/59 (15%)
		leucine-rich repeat	114..137	CDD:275378	4/22 (18%)
		leucine-rich repeat	138..161	CDD:275378	2/22 (9%)
		LRR_8	160..214	CDD:290566	9/54 (17%)
		LRR_4	160..201	CDD:289563	5/40 (13%)
		leucine-rich repeat	162..185	CDD:275378	5/22 (23%)
		leucine-rich repeat	186..199	CDD:275378	0/12 (0%)
		leucine-rich repeat	215..230	CDD:275378	5/14 (36%)
		Ig	278..391	CDD:299845	28/122 (23%)
		I-set	279..391	CDD:254352	27/121 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900