DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and vsig10

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001093564.2	Gene:	vsig10 / 100005564	ZFINID:	ZDB-GENE-030131-7476	Length:	529	Species:	Danio rerio

Alignment Length:	531	Identity:	109/531 - (20%)
Similarity:	182/531 - (34%)	Gaps:	110/531 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 QTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNP-------E 254
            |.:|.:.|.:..|.|....:....:.:...:||.:        :|.|.     .|||       |
Zfish    26 QFVIGEKGNNTTLHCLDHPVNASSVLYQWKKDGAV--------VATQN-----PPNPSVHLSISE 77

  Fly   255 RWSLQIKYVQLKDEGTYECQVSTEPKAS----AIVHLRI----------VEPKTELIGESTRHVK 305
            ...|:|..:||.|||.|||:...:...|    :.:.|.|          :.|.| .:...|..|.
Zfish    78 NGFLRISGLQLIDEGLYECESQAKGGRSWQTLSKIQLTIAAGPTGVSLDISPAT-FLNNGTLFVH 141

  Fly   306 AGSQVKLRCIISQALEPPLFINWFY-----NQKQIYLHNRRGWRTEIERIDLPAEVPTTSTTTTT 365
            .||.|...|  |....|...:.|..     :..:....::......|..|. |.:..|.:.|:..
Zfish   142 KGSNVNFSC--SSESNPSQNLTWTVDNLASDNPEREFGSKSPLAFSITNIQ-PLDQGTYTCTSQN 203

  Fly   366 TTTTASTTTTTTSTTPATPSTTATGSTE-GATSSETLNGLVTITRSYILDAISQNDVSELGAAAG 429
            |.:..:...|........|......|.| |...|:.| .:.:....|.:..::..:|.  |||.|
Zfish   204 TLSRRTANKTQELLVYYAPERHPECSWELGDKPSDVL-FICSWFGGYPVPTLTWQEVE--GAAEG 265

  Fly   430 VAVATETSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITTA---ATGDSAATAATT 491
            ..:  ..:|:|...|:..:.:.|....|..:..:.........:...|..   .||...|||
Zfish   266 PTI--NLTTSQQTEELNVSVNRSILHDGDKVKCTGHHVTGVEKSCSFTLKIPYPTGQPLATA--- 325

  Fly   492 SAWLTTMDAEAATTAATTTTTMLP--------------SSSFIKQIT--TASLIIPAVVKLDSGN 540
                  ::....|.:.|.|:::.|              :|.:|.|..  ..:|.|..|.|.|.|.
Zfish   326 ------LEGTNITISCTETSSLPPAKTVWKKNDDLIENTSKYIVQENRPALTLTIVNVTKADEGV 384

  Fly   541 YTCSPSNSAPRTIVLHVLNGEYSASAIKSGSVSWSALIGCHGYLHWRNVSTLLTLLWI---IKFA 602
            |.|...|......:...||       :|:.:.:..|::|..       ||.|:.::.|   :...
Zfish   385 YYCYSENPLGARELEVYLN-------VKTSAGNGGAIVGIF-------VSVLVMMIGIVVGVTVY 435

  Fly   603 LARD-ICQPNATSKA-TTRTSLLRAGDGATADVTRETGPK-----SG-----ASFHRVSS----S 651
            ..|| ||.....|:. ..|..:|...|....::..|..|:     :|     ...||:.|    .
Zfish   436 TKRDRICIGLRFSQLDDDRVDVLSLVDSDEEEIFHEAVPRLPPVTNGHATTLVEIHRIPSCDHED 500

  Fly   652 ISATKVAEDKT 662
            |:.:....|:|
Zfish   501 IADSTEQSDQT 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	25/102 (25%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	24/106 (23%)
vsig10	NP_001093564.2	IG_like	28..116	CDD:214653	24/100 (24%)
		Ig	32..104	CDD:299845	21/84 (25%)
		IG_like	140..204	CDD:214653	13/66 (20%)
		IGc2	143..203	CDD:197706	12/62 (19%)
		IG_like	324..404	CDD:214653	20/95 (21%)
		Ig	328..404	CDD:299845	18/82 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910