DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr17 and PAPLN

DIOPT Version :9

Sequence 1:	NP_001287297.1	Gene:	dpr17 / 41470	FlyBaseID:	FBgn0051361	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_001352835.1	Gene:	PAPLN / 89932	HGNCID:	19262	Length:	1278	Species:	Homo sapiens

Alignment Length:	340	Identity:	78/340 - (22%)
Similarity:	109/340 - (32%)	Gaps:	116/340 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   396 GGDGA-------GSAVRRNL--TMPVLNITAQMGNHAYMPCQIHRLSDKPVSWVRMRDNHIISVD 451
            |||..       .|:.|.:|  ..|.| :.|.:|....:.|......:...:|  .:|...||.|
Human   892 GGDAGSPAPPFHSSSYRISLAGVEPSL-VQAALGQLVRLSCSDDTAPESQAAW--QKDGQPISSD 953

  Fly   452 ETTFIADERFQSIYQEDHDYTWSLQIKYVEPSDAGWYECQMATEPKLSAKVHLQIV--------- 507
            .      .|.|        :..||.|..::..|||.|.|......:.|.|:.|:|:
Human   954 R------HRLQ--------FDGSLIIHPLQAEDAGTYSCGSTRPGRDSQKIQLRIIGGDMAVLSE 1004

  Fly   508 ---------------------------------KPKTELIGDQS--RFVKA--GSKVALHCIVRG 535
                                             :|...|..||:  |.|.|  |.::.:.|...|
Human  1005 AELSRFPQPRDPAQDFGQAGAAGPLGAIPSSHPQPANRLRLDQNQPRVVDASPGQRIRMTCRAEG 1069

  Fly   536 TLDPPKYIIWFRGQKKISDSDERTGWYTQLDRNIFGTVGDNQNTIGSLIIPLVRKEDSGNYTCQP 600
            .  ||..|.|.|..:.:|....      ||..:            |||:|..|..||.|.|||..
Human  1070 F--PPPAIEWQRDGQPVSSPRH------QLQPD------------GSLVISRVAVEDGGFYTCVA 1114

  Fly   601 SNSVSVS---VDLHVLSGEYSASAIMSTAARTTKGGRSTCHSTLGLLGI-----LGLLWAMQG-- 655
            .|.....   |.|.|| ||.:.|.:..|.  |...|     .|..||.:     :.:.|:..|
Human  1115 FNGQDRDQRWVQLRVL-GELTISGLPPTV--TVPEG-----DTARLLCVVAGESVNIRWSRNGLP 1171

  Fly   656 ------AMHTPPTQT 664
                  .:|..|..|
Human  1172 VQADGHRVHQSPDGT 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr17	NP_001287297.1	IG_like	414..491	CDD:214653	17/76 (22%)
		Ig	415..507	CDD:299845	21/91 (23%)
		IG_like	521..612	CDD:214653	27/95 (28%)
		IGc2	524..605	CDD:197706	23/80 (29%)
PAPLN	NP_001352835.1	TSP1	29..80	CDD:214559
		ADAM_spacer1	183..298	CDD:310520
		TSP1	308..361	CDD:214559
		TSP1	369..424	CDD:214559
		TSP1	424..481	CDD:214559
		TSP1	488..539	CDD:214559
		Kunitz_BPTI	753..805	CDD:278443
		Papilin_u7	814..905	CDD:318767	3/12 (25%)
		Ig	914..>978	CDD:325142	19/80 (24%)
		I-set	1049..1119	CDD:254352	26/89 (29%)
		IG	1139..1219	CDD:214652	11/55 (20%)
		PLAC	1235..1267	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900