DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr17 and USH2A

DIOPT Version :9

Sequence 1:	NP_001287297.1	Gene:	dpr17 / 41470	FlyBaseID:	FBgn0051361	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_996816.3	Gene:	USH2A / 7399	HGNCID:	12601	Length:	5202	Species:	Homo sapiens

Alignment Length:	597	Identity:	106/597 - (17%)
Similarity:	177/597 - (29%)	Gaps:	207/597 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LPALGFGIQVVTCSNPELGASAPDPVDLTWGGKNTEGQLTTATRSTLPDSPMTTQNDLITTASNL 170
            ||....||     .:|||.:..|..|.::|                   .|.|..|.|:...:..
Human  2620 LPGAPEGI-----PSPELFSDTPTSVIISW-------------------QPPTHPNGLVENFTIE 2660

  Fly   171 ATAKKPATAASEAVVDTAETAETAPPTEATSSWSSTAVARGMSSADGAGEAIATSQSAQIGLTTQ 235
            ...|......:...:..:.:......|.|.|.|:.......||:..|     .|:.||.:.:||:
Human  2661 RRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHG-----GTNSSAWVEVTTR 2720

  Fly   236 -----------ATVRQTEA----------QTASTATQAAAATSAATSAAIASAAAATETAAEMLI 279
                       .||.:.:|          |.....:..........:....::|..::....::.
Human  2721 PSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITLTNVTSAVLSQKVTHLIP 2785

  Fly   280 STIYPASTETDLHNSIERVEGQRGKMAN---------AFHPGVPDS--------LTKGFSIPTFL 327
            .|.|..        :|....|..|.:..         ..||.||.:        |::.:.:.::.
Human  2786 FTNYSV--------TIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQ 2842

  Fly   328 PPFPVFAAADLPAYRAAADAAEAAKLAAEAAAQAAAAKTSSEAVTMSPEEQRRQMFNEQHSYLAA 392
            ||    :..:.|..|                .:....|......:..||:     .|..|:..:.
Human  2843 PP----SKPNGPNLR----------------YELLRRKIQQPLASNPPED-----LNRWHNIYSG 2882

  Fly   393 ----HRDGG--------------DGAGSAVRRNLTMPVL--------NITAQMGNHAYMPCQIHR 431
                :.|.|              :..|....|.:|:..|        |:||.:.||..:
Human  2883 TQWLYEDKGLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTAI------ 2941

  Fly   432 LSDKPVSWVRMRDNHIISVDETTFIADERFQSIYQEDHDYT--WSLQIKYVEPSDAGWYECQMAT 494
                .|.|                 |....|.:..|...||  ||    ....:|:      :..
Human  2942 ----DVRW-----------------AKPTVQDLQGEVEYYTLFWS----SATSNDS------LKI 2975

  Fly   495 EPKLSAKV--HLQIVKPKTELIGDQSRF--VKAGSKVALHCIV-----RGTLDPPKYIIWFRGQK 550
            .|.:::.|  ||   ||.||.....|.|  |.:.:...||...     :|.| ||:.:|
Human  2976 LPDVNSHVIGHL---KPNTEYWIFISVFNGVHSINSAGLHATTCDGEPQGML-PPEVVI------ 3030

  Fly   551 KISDSDERTGWYTQLDRNIFGTVGD------------NQNTIGSLII----PL----VRKEDSGN 595
             |:.:..|..|.:..:.|  |.|.:            ..|..||.|:    |.    ::.|....
Human  3031 -INSTAVRVIWTSPSNPN--GVVTEYSIYVNNKLYKTGMNVPGSFILRDLSPFTIYDIQVEVCTI 3092

  Fly   596 YTCQPSNSVSVS 607
            |.|..||...::
Human  3093 YACVKSNGTQIT 3104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr17	NP_001287297.1	IG_like	414..491	CDD:214653	15/78 (19%)
		Ig	415..507	CDD:299845	18/95 (19%)
		IG_like	521..612	CDD:214653	24/112 (21%)
		IGc2	524..605	CDD:197706	23/105 (22%)
USH2A	NP_996816.3	LamGL	146..283	CDD:214722
		Laminin_N	291..516	CDD:413488
		EGF_Lam	517..565	CDD:238012
		EGF_Lam	574..639	CDD:238012
		Laminin_EGF	641..691	CDD:395007
		EGF_Lam	694..733	CDD:214543
		Laminin_EGF	747..795	CDD:395007
		EGF_Lam	794..844	CDD:238012
		EGF_Lam	847..897	CDD:214543
		EGF_Lam	900..948	CDD:238012
		EGF_Lam	950..1000	CDD:238012
		EGF_Lam	1001..>1037	CDD:238012
		fn3	1058..1132	CDD:394996
		fn3	1150..1227	CDD:394996
		FN3	1242..1357	CDD:238020
		FN3	1368..1451	CDD:214495
		LamG	1519..1678	CDD:238058
		LamG	1716..1868	CDD:238058
		FN3	1956..2051	CDD:238020
		FN3	2241..2313	CDD:238020
		FN3	2329..2428	CDD:238020
		FN3	2432..2528	CDD:238020
		FN3	2533..2619	CDD:238020
		FN3	2621..2719	CDD:238020	24/126 (19%)
		FN3	2724..2799	CDD:238020	8/82 (10%)
		FN3	2818..2920	CDD:238020	18/126 (14%)
		FN3	2925..3015	CDD:238020	28/129 (22%)
		FN3	3026..>3087	CDD:238020	13/69 (19%)
		FN3	<3449..3494	CDD:238020
		FN3	3503..3586	CDD:238020
		FN3	3590..3676	CDD:238020
		FN3	3680..3767	CDD:238020
		fn3	3777..3856	CDD:394996
		FN3	3866..3960	CDD:238020
		FN3	3964..4057	CDD:238020
		fn3	4161..4247	CDD:394996
		FN3	4268..4351	CDD:238020
		fn3	4357..4428	CDD:394996
		FN3	4444..4516	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4518..4541
		FN3	4529..4627	CDD:238020
		FN3	4636..4730	CDD:238020
		FN3	4826..4927	CDD:238020
		PDZ-binding	5200..5202
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900