DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr17 and sdk1a

DIOPT Version :9

Sequence 1:	NP_001287297.1	Gene:	dpr17 / 41470	FlyBaseID:	FBgn0051361	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	XP_009297968.1	Gene:	sdk1a / 558391	ZFINID:	ZDB-GENE-081104-374	Length:	2245	Species:	Danio rerio

Alignment Length:	718	Identity:	136/718 - (18%)
Similarity:	228/718 - (31%)	Gaps:	253/718 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 KSSSSWSSTSRRTGISRTRTRPATLTTEMTVAGRAERAGVGAPW------CRR------------ 86
            ||:||.||:...|..|           ...|:|..:|......|      |.:
Zfish    70 KSASSSSSSMIFTHFS-----------GRNVSGNGKRKFAVRTWSWWAFFCLQVHVLEAVTQGDV 123

  Fly    87 --FFHTSPLASWLRISFVLLVLPALGFGIQVVTCSNPELGASAPDPVDLTWGGKNTEGQLTTA-- 147
              :|.|.|....:.:....||:..|               |....|::..|...||:   .||
Zfish   124 APYFKTEPGPPEIHLEGNRLVMTCL---------------AEGSWPLEFKWMLNNTD---ITAFS 170

  Fly   148 -----TRSTLPDSPM--------TTQNDLITTASNLATA----------KKPATAASEAVVDTAE 189
                 |.|:|..|.|        .....|:...:.:..|          :|..|....|::::..
Zfish   171 PEYKYTISSLQRSNMGVYQCVVRNRMGALLQKKAEIQVAYMGDFIDNDQRKTVTQGRAAILNSPA 235

  Fly   190 TA--------------ETAPPTEATSSWSSTAVARGMSSADGAG----EAI-------ATSQSAQ 229
            .:              :..|......:..:..|..|.:::| ||    :|:       .||.|..
Zfish   236 VSCFPRPQVTWFRDGYKIIPSNRIAITLENQLVVLGTAASD-AGRYYVQAVNEKNGENKTSPSIY 299

  Fly   230 IGLTTQATVR---QTEAQTASTA---------TQAAAATSAATSAAIASAAAATETAAEMLISTI 282
            :.:......|   .:||.....|         |...|..|.||...:|:|....:      :|.:
Zfish   300 LNVAANKKYRGSHDSEAPADPVAPVIVIPPRNTTVVAGISEATLECVANARPVEK------LSLV 358

  Fly   283 YPASTETDLHNSIERVEGQRGKMANAFHPGVPDSLTKGFSI--PTFLPPFPVFAAADLPAYRAAA 345
            :       ..|.:|...|             ..|.::..:|  ||         :.|:..|...|
Zfish   359 W-------RRNGVEVASG-------------VGSFSRRLTIINPT---------STDVGMYVCEA 394

  Fly   346 DAAEAAKLAAEAAAQAAAAKTSSEAVTMSP---EEQRRQMFNEQHSYLAAHRDGGDGAGSAVRRN 407
            ...:::...|||.|..        ::|.:|   .|.||:|..|                  |.::
Zfish   395 LLLDSSVKPAEARAFL--------SITEAPYFTAEPRRKMMGE------------------VEKS 433

  Fly   408 LTMPVLNITAQMGNHAYMPCQIHRLSDKPVSWVRMRDNHIISVDETTFIADERFQSIYQEDHDYT 472
            :.               :.||...:....:.|.:       .....:.:.:.|::.|      .:
Zfish   434 VD---------------IQCQARGVPMPKLEWYK-------DAVPLSKLNNPRYKII------SS 470

  Fly   473 WSLQIKYVEPSDAGWYECQMATEPKLSAKVHLQI---------VKPKTELIGDQSRFVKAGSKVA 528
            ..||::.::|||||.::| .|......|:||..:         ..|..::.      |..|:..|
Zfish   471 MGLQVRKLQPSDAGIFQC-FARNSAGEAQVHTYLDVTSMAPAFTAPPLDIT------VTDGAVAA 528

  Fly   529 LHCIVRGTLDPPKYIIWFRGQKKISDSDERTGWYTQLDRNIFGTVGDNQNTIGSLIIPLVRKEDS 593
            ..|.|.|.  |...|:|.|..:.::....:...:|.|:.             |.|.|..|..:|:
Zfish   529 FTCRVSGA--PKPAIVWRRDTQILASGSVQIPRFTLLES-------------GGLQIQPVVLQDT 578

  Fly   594 GNYTCQPSNSVSVSVDLHVLSGEYSASAIMSTAARTTKGGRSTCHSTL-GLLGILGLLWAMQGAM 657
            |||||..:||          .|..:|||.::..:||:.....|....: |...||..     ||.
Zfish   579 GNYTCYAANS----------EGAINASASLTVWSRTSISSPPTDRRVIKGTTAILEC-----GAT 628

  Fly   658 HTP 660
            |.|
Zfish   629 HDP 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr17	NP_001287297.1	IG_like	414..491	CDD:214653	12/76 (16%)
		Ig	415..507	CDD:299845	17/100 (17%)
		IG_like	521..612	CDD:214653	24/90 (27%)
		IGc2	524..605	CDD:197706	23/80 (29%)
sdk1a	XP_009297968.1	I-set	125..208	CDD:254352	19/100 (19%)
		Ig	125..204	CDD:299845	19/96 (20%)
		IG_like	222..302	CDD:214653	12/80 (15%)
		Ig	236..287	CDD:299845	7/51 (14%)
		Ig_3	322..394	CDD:290638	18/106 (17%)
		I-set	323..412	CDD:254352	22/131 (17%)
		I-set	416..505	CDD:254352	24/135 (18%)
		Ig	436..500	CDD:299845	15/77 (19%)
		I-set	510..600	CDD:254352	29/120 (24%)
		Ig	527..600	CDD:299845	26/97 (27%)
		I-set	605..693	CDD:254352	8/32 (25%)
		Ig	610..693	CDD:299845	8/27 (30%)
		FN3	697..788	CDD:238020
		fn3	800..886	CDD:278470
		FN3	901..997	CDD:238020
		FN3	1002..1090	CDD:238020
		FN3	1100..1196	CDD:238020
		FN3	1206..1301	CDD:238020
		FN3	1308..1397	CDD:238020
		FN3	1408..1501	CDD:238020
		FN3	1507..1602	CDD:238020
		FN3	1616..1722	CDD:238020
		FN3	1732..1825	CDD:238020
		FN3	1830..1919	CDD:238020
		FN3	1931..2021	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810