DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr17 and Sdk2

DIOPT Version :9

Sequence 1:	NP_001287297.1	Gene:	dpr17 / 41470	FlyBaseID:	FBgn0051361	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	XP_006247755.1	Gene:	Sdk2 / 360652	RGDID:	1310397	Length:	2175	Species:	Rattus norvegicus

Alignment Length:	613	Identity:	119/613 - (19%)
Similarity:	188/613 - (30%)	Gaps:	207/613 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 FFHTSPLASWLRISFVLLVLPALGFGIQVVTCSNPELGASAPDPVDLTWGGKNTEGQLTTATRST 151
            :|.|.|:.:.:.:....|||          ||.     |....|::..|...|.|     .||.:
  Rat    30 YFKTEPVRTQVHLEGNRLVL----------TCM-----AEGSWPLEFKWLHNNRE-----LTRFS 74

  Fly   152 LPDSPMTTQND-----------------LITTASNLATA---------KKPATAASEAVVDTAET 190
            |....|.|..|                 |:...:.:..|         |..:.:..||.|..|..
  Rat    75 LEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIKAPR 139

  Fly   191 AETAPPTEATSSWSSTAVARGMSSADGAGEAIATSQSAQIGLTTQATVRQTEAQTASTATQAAAA 255
            ..:.|..:.|  |          ..||.    ....|::|.:|.:.|:
  Rat   140 ISSFPRPQVT--W----------FRDGR----KIPPSSRIAITLENTL----------------- 171

  Fly   256 TSAATSAAIASAAAATETAAEMLISTIYPAS----------------TETDLHNSIERVEGQRGK 304
                                 :::||:.|.:                |...:..::|.|.|....
  Rat   172 ---------------------VILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLAVENVGGPADP 215

  Fly   305 MANAFHPGVPDSLTKGFSIPT-FLPP--FPVFAAADLPAYRAAADAAEAAKLAAEAAAQAAAAKT 366
            :|                 || .:||  ..|.|..........|:|....||........|....
  Rat   216 IA-----------------PTIIIPPKNTSVVAGTSEVTMECVANARPLIKLHIVWKKDGALLSN 263

  Fly   367 SSEAVTMSPEEQRRQMFNEQHSYLAAHRDGG---------DGAGSAVRRNLTMPVL--------- 413
            .     :|...:|..:.|...|      |.|         ..:.:.|.|...:.||
  Rat   264 G-----ISDYNRRLTITNPMVS------DAGYYECEAMLRSSSVAPVTRGAYLSVLEPPQFVREP 317

  Fly   414 --NITAQMGNHAYMPCQIHRLSDKPVSWVRMRDNHIISVDETTFIADERFQSIYQEDHDYTWSLQ 476
              :|||:|.....:||:...:....::|  .:|..::.|.:.|     ||:.  :.|    ..||
  Rat   318 ERHITAEMEKVVDIPCRAKGVPPPSITW--YKDAALVEVGKLT-----RFKQ--RSD----GGLQ 369

  Fly   477 IKYVEPSDAGWYEC---QMATEPKLSAKVHLQIVKPKTELIGDQSRFVKAGSKVALHCIVRGTLD 538
            |..:.|.|.|..:|   ..|.|.:.|..:.:..:.|.... |.....|..|..|.|.|...|.
  Rat   370 ISGLLPDDTGMVQCFAHNAAGEAQTSTYLAVTSIAPNITR-GPLDSTVIDGMSVVLACETSGA-- 431

  Fly   539 PPKYIIWFRGQKKISDSDERTGWYTQLDRNIFGTVGDNQNTIGSLIIPLVRKEDSGNYTCQPSNS 603
            |...|.|.:|::.::....:...:|.|:.             |||:|......|:|.|||..:||
  Rat   432 PRPAITWQKGERILASGSVQLPRFTLLES-------------GSLLISPTHISDAGTYTCLATNS 483

  Fly   604 VSVSVDLHVLSGEYSASAIMSTAARTTK 631
            ..|.        |.||..::....|.||
  Rat   484 RGVD--------EASADLVVWARTRITK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr17	NP_001287297.1	IG_like	414..491	CDD:214653	20/79 (25%)
		Ig	415..507	CDD:299845	23/94 (24%)
		IG_like	521..612	CDD:214653	24/90 (27%)
		IGc2	524..605	CDD:197706	22/80 (28%)
Sdk2	XP_006247755.1	IG_like	43..112	CDD:214653	17/88 (19%)
		IGc2	43..101	CDD:197706	16/77 (21%)
		IG_like	123..206	CDD:214653	18/136 (13%)
		Ig	135..191	CDD:299845	13/109 (12%)
		IG_like	225..307	CDD:214653	15/92 (16%)
		IGc2	236..289	CDD:197706	11/63 (17%)
		I-set	311..400	CDD:254352	23/101 (23%)
		Ig	329..397	CDD:143165	19/80 (24%)
		I-set	405..495	CDD:254352	29/113 (26%)
		Ig	419..495	CDD:299845	26/98 (27%)
		Ig	505..589	CDD:299845
		IG_like	505..589	CDD:214653
		FN3	593..684	CDD:238020
		FN3	696..789	CDD:238020
		FN3	797..893	CDD:238020
		FN3	898..986	CDD:238020
		FN3	996..1090	CDD:238020
		FN3	1102..1197	CDD:238020
		FN3	1204..1293	CDD:238020
		FN3	1304..1397	CDD:238020
		FN3	1403..1487	CDD:238020
		FN3	1506..1619	CDD:238020
		FN3	1629..1722	CDD:238020
		FN3	1727..1808	CDD:238020
		FN3	1840..1919	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810