DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr17 and Lrit3

DIOPT Version :9

Sequence 1:	NP_001287297.1	Gene:	dpr17 / 41470	FlyBaseID:	FBgn0051361	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_001274153.1	Gene:	Lrit3 / 242235	MGIID:	2685267	Length:	681	Species:	Mus musculus

Alignment Length:	347	Identity:	67/347 - (19%)
Similarity:	115/347 - (33%)	Gaps:	89/347 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 LPPFPVFAAADLPAYRAA----ADAAEAAKLAAEAAAQAAAAKTSSEAVTMSPEEQRRQMFNEQH 387
            |..||..:..|:|..|..    ...|.....|............||..:|..|.:     |.:..
Mouse   117 LTAFPWVSLLDMPHLRTLDLHNNRIASVPNEAVRYLRNLTCLDLSSNRLTTLPPD-----FLDSW 176

  Fly   388 SYLAAHRDGGDGAGSAVRRNLTMPVLNITAQMGNHAYMPCQIHRLSDKPVSWVRMRDNHIISVDE 452
            |:||.          ...|:...|...|...:.::.:. |..|  ..|.:...::.|:.::.:|.
Mouse   177 SHLAV----------TPSRSPDFPPRRIILGLQDNPWF-CDCH--ISKVIELSKVTDHAVVLLDP 228

  Fly   453 TTFIAD-ERFQSIYQEDHDYTWSLQIKYVEPSDAGWYECQMATEPKLSAKVHLQIVKPKTELIGD 516
            ....:: ||||.|..:                       ::..|..|...|.:...|..:.|
Mouse   229 LMVCSEPERFQGILFQ-----------------------RVELEKCLKPSVMMSATKITSAL--- 267

  Fly   517 QSRFVKAGSKVALHCIVRGTLDPPKYIIWFRGQKKISDSDERTGWYTQLDRNIFGTVGDNQNTIG 581
                   ||.|.|.|..:|  .|...:.|.|       ||..|..||.:..:      ..:....
Mouse   268 -------GSNVLLRCDAKG--HPTPQLTWTR-------SDGSTVNYTVIQES------PGEGIRW 310

  Fly   582 SLI-IPLVRKEDSGNYTCQPSNSVSVS---VDLHVLSGEYSASAIMSTAARTTKGGRSTCHSTLG 642
            |:| :..:..:|:|:|.|:..|...:|   |.:.|:.|  ..:.:...::..:.|.....|...|
Mouse   311 SIISLTSISHKDAGDYRCKAKNLAGISEAVVTVTVVGG--VTTTLSPDSSERSPGEPPEQHPQPG 373

  Fly   643 LLGILGLLWAMQGAMHTPPTQT 664
            |.|            .|||:::
Mouse   374 LGG------------STPPSKS 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr17	NP_001287297.1	IG_like	414..491	CDD:214653	11/77 (14%)
		Ig	415..507	CDD:299845	14/92 (15%)
		IG_like	521..612	CDD:214653	23/94 (24%)
		IGc2	524..605	CDD:197706	21/81 (26%)
Lrit3	NP_001274153.1	LRR 1. /evidence=ECO:0000255	56..79
		LRR_8	61..117	CDD:290566	67/347 (19%)
		LRR 2. /evidence=ECO:0000255	80..103
		leucine-rich repeat	83..106	CDD:275378
		LRR 3. /evidence=ECO:0000255	104..128		3/10 (30%)
		LRR_8	105..165	CDD:290566	10/47 (21%)
		LRR_4	106..146	CDD:289563	7/28 (25%)
		leucine-rich repeat	107..130	CDD:275378	4/12 (33%)
		LRR_4	129..170	CDD:289563	7/40 (18%)
		LRR 4. /evidence=ECO:0000255	129..151		4/21 (19%)
		leucine-rich repeat	131..154	CDD:275378	3/22 (14%)
		LRR 5. /evidence=ECO:0000255	152..175		5/27 (19%)
		leucine-rich repeat	155..168	CDD:275378	3/12 (25%)
		Ig	254..335	CDD:299845	24/105 (23%)
		IG_like	263..339	CDD:214653	23/100 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..391		8/46 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..464
		FN3	489..563	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900