DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr17 and Lrit1

DIOPT Version :9

Sequence 1:	NP_001287297.1	Gene:	dpr17 / 41470	FlyBaseID:	FBgn0051361	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_666357.2	Gene:	Lrit1 / 239037	MGIID:	2385320	Length:	624	Species:	Mus musculus

Alignment Length:	326	Identity:	74/326 - (22%)
Similarity:	107/326 - (32%)	Gaps:	122/326 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 TMSPEEQRRQMFNEQHSYLAAHRDGGDGAGSAVRRNLTMPVLNITAQM-------GNHAYMPCQI 429
            |:.||...   |.|..::|       |.:.:.:.| |...:|::.|.:       |:||.:   |
Mouse   145 TLPPEAAH---FLENLTFL-------DLSNNQLMR-LPEELLDVWAHLKTGPFLSGHHARL---I 195

  Fly   430 HRLSDKPVSWV---RMRD----------NHIISVDETTFIADERFQSIYQEDHDYTWSLQIKYVE 481
            ..|.|.|  ||   |:.|          :::|.::.....|..|               .:..|.
Mouse   196 LGLQDNP--WVCDCRLYDLVHLLDGWVSSNLIFIEARLRCASPR---------------SLAGVA 243

  Fly   482 PSDAGWYECQMATEPKLSAKVHLQIVKPKTELIGDQSRFVKAGSKVALHCIVRGTLDPPKYIIWF 546
            .|.....:||   .|:|...| ..|:.|             .||.|.|.|...|...|
Mouse   244 FSQLELRKCQ---SPELRPGV-TSIISP-------------LGSTVLLRCGATGIPGP------- 284

  Fly   547 RGQKKISDSDERTGWYTQLDRNIFGTVGDNQNTIGS----LIIPLVRKEDSGNYTCQPSNSVSVS 607
                       ...|.....|.:.|||....::.||    |.:|:|...|||:|.||..|.:..|
Mouse   285 -----------EMSWRRANGRPLNGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQAKNFLGAS 338

  Fly   608 VDLHVLSGEYSASAIMSTAARTTKGGRSTCHSTLGLLGILGLLWAMQG-------------AMHT 659
                    |...|.|::....:|           |..||.|:|||..|             |.|.
Mouse   339 --------ETLISLIVTEPQTST-----------GYSGIPGVLWARTGEGAEAAAYNNKLVARHV 384

  Fly   660 P 660
            |
Mouse   385 P 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr17	NP_001287297.1	IG_like	414..491	CDD:214653	17/96 (18%)
		Ig	415..507	CDD:299845	22/111 (20%)
		IG_like	521..612	CDD:214653	25/94 (27%)
		IGc2	524..605	CDD:197706	24/84 (29%)
Lrit1	NP_666357.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..129
		LRR_8	131..>176	CDD:290566	9/41 (22%)
		LRR_4	131..172	CDD:289563	9/37 (24%)
		LRR 4	132..153		3/10 (30%)
		leucine-rich repeat	133..156	CDD:275378	4/13 (31%)
		LRR 5	156..177		5/28 (18%)
		leucine-rich repeat	157..180	CDD:275378	5/30 (17%)
		leucine-rich repeat	181..205	CDD:275378	8/28 (29%)
		TPKR_C2	201..>241	CDD:301599	8/56 (14%)
		Ig	258..346	CDD:299845	30/127 (24%)
		IG_like	268..346	CDD:214653	27/103 (26%)
		FN3	432..502	CDD:214495
		LRR 6	526..549
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900