DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr17 and DSCAM

DIOPT Version :9

Sequence 1:	NP_001287297.1	Gene:	dpr17 / 41470	FlyBaseID:	FBgn0051361	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens

Alignment Length:	330	Identity:	74/330 - (22%)
Similarity:	106/330 - (32%)	Gaps:	129/330 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 SYL----AAHRDGG-------DGAGSAV---RRNL-----TMPVLNITAQMGNHAYMPCQIHRLS 433
            |||    :..||||       :.||..:   |.|:     ..|:.||||..|...|:.|::....
Human   467 SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYP 531

  Fly   434 DKPVSWVRMRD----NHIISVDETTFIADERFQSIYQEDHDYTWSLQIKYVEPS-DAGWYECQMA 493
            ...:.|.:..:    ||                  .|...:...:|::..|:.. |.|.|.|.:.
Human   532 YYSIKWYKNSNLLPFNH------------------RQVAFENNGTLKLSDVQKEVDEGEYTCNVL 578

  Fly   494 TEPKLSA--KVHLQIVKPKTELIGDQSRFVKAGSKVALHCIVRGTLDPPKYIIW----------- 545
            .:|:||.  .||:.:..|......:..|| ..|.:|.:.|:|... |.|..|.|
Human   579 VQPQLSTSQSVHVTVKVPPFIQPFEFPRF-SIGQRVFIPCVVVSG-DLPITITWQKDGRPIPGSL 641

  Fly   546 --------FRGQKKISD-SDERTGWYTQLDRN----------------------------IFGTV 573
                    |....:||: |....|.||.:.||                            |:|..
Human   642 GVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKA 706

  Fly   574 --------GDNQNTI---------------------------GSLIIPLVRKEDSGNYTCQPSNS 603
                    |....||                           |||:|..|.:||||.|.|:.||.
Human   707 VILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSND 771

  Fly   604 VSVSV 608
            |...|
Human   772 VGADV 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr17	NP_001287297.1	IG_like	414..491	CDD:214653	16/81 (20%)
		Ig	415..507	CDD:299845	21/98 (21%)
		IG_like	521..612	CDD:214653	37/171 (22%)
		IGc2	524..605	CDD:197706	35/163 (21%)
DSCAM	NP_001380.2	Ig	45..113	CDD:319273
		I-set	235..310	CDD:254352
		I-set	315..385	CDD:333254
		Ig_3	407..488	CDD:316449	7/20 (35%)
		IGc2	518..575	CDD:197706	12/74 (16%)
		I-set	596..686	CDD:333254	20/91 (22%)
		Ig_DSCAM	707..784	CDD:143211	18/70 (26%)
		Ig	802..889	CDD:325142
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810