DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr17 and Papln

DIOPT Version :9

Sequence 1:	NP_001287297.1	Gene:	dpr17 / 41470	FlyBaseID:	FBgn0051361	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_001192272.1	Gene:	Papln / 170721	MGIID:	2386139	Length:	1302	Species:	Mus musculus

Alignment Length:	386	Identity:	80/386 - (20%)
Similarity:	134/386 - (34%)	Gaps:	106/386 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 PGVPDSLTKGFSI------PTFLPPFP-----VFAAADLPA-----------------YRAAADA 347
            |.||.:.:..:.|      |:.:...|     :|...::|:                 |:..||.
Mouse   914 PAVPPTHSPSYRIRLAGSEPSLVQAAPGQAVQLFCPGNIPSEFQAGWQKEGRPISSNRYQLQADG 978

  Fly   348 A-EAAKLAAEAAA-------------QAAAAKTSSEAVTMSPEEQRRQMFNEQHSYLA---AHRD 395
            : ..::|..|.|.             |....:.:...:.:.||.|.|.....::..|.   .||.
Mouse   979 SLIISRLRPEDAGIYSCGSHRPGHEPQEIQLRVTGGDMAVFPEGQPRHFPEPRNPDLGHGPPHRG 1043

  Fly   396 GGDGAG-------------SAVRRNLTMPVLNITAQMGNHAYMPCQIHRLSDKPVSWVRMRDNHI 447
            .|..||             :.:|.:.|.|.: :.|..|....:.|:........:.|  .||..:
Mouse  1044 TGAEAGGHRVLSPSHPRPATRLRLDRTQPGV-VDASPGQRIRLTCRAEGFPVPTIEW--QRDGQL 1105

  Fly   448 ISVDETTFIADERFQSIYQEDHDYTWSLQIKYVEPSDAGWYEC-QMATEPKLSAKVHLQIVKPKT 511
            :|        ..|.|  .|.|    .||.|..|:..|.|:|.| ....:.:....|.|::::..|
Mouse  1106 VS--------SPRHQ--VQPD----GSLVISRVDVEDGGYYSCVAFNGQDRDQRWVQLRVLRELT 1156

  Fly   512 ELIGDQSRFVKAGSKVALHCIVRGTLDPPKYIIWFRGQKKISDSDERTGWYTQLDRNIFGTVGDN 576
            ......:..|..|....|.|:|.|   ....|.|.|....|.....|.                :
Mouse  1157 ITGLPPAVTVAEGDTARLLCVVAG---ESVNIRWSRNGLPIQADGHRV----------------H 1202

  Fly   577 QNTIGSLIIPLVRKEDSGNYTC---QPSNSVSVSVDLHVLSGEYSASAIMSTAARTTKGGR 634
            |:..|:|:|..:|..|.|:|||   :.|.:||.|.::.|        |:.:.||::...|:
Mouse  1203 QSPDGTLLIHNLRPRDEGSYTCSAFRGSQAVSRSTEVKV--------ALPAPAAQSRDLGK 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr17	NP_001287297.1	IG_like	414..491	CDD:214653	19/77 (25%)
		Ig	415..507	CDD:299845	21/92 (23%)
		IG_like	521..612	CDD:214653	25/93 (27%)
		IGc2	524..605	CDD:197706	21/83 (25%)
Papln	NP_001192272.1	TSP1	30..81	CDD:214559
		ADAM_spacer1	184..299	CDD:368694
		TSP1	309..362	CDD:214559
		TSP1	389..447	CDD:214559
		TSP1	447..504	CDD:214559
		TSP1	511..562	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..737
		Kunitz_BPTI	771..822	CDD:333766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..924		3/9 (33%)
		Papilin_u7	831..922	CDD:374683	3/7 (43%)
		Ig	932..>995	CDD:386229	10/62 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1064		7/39 (18%)
		I-set	1070..1141	CDD:369462	21/87 (24%)
		Ig	1157..1241	CDD:386229	25/102 (25%)
		PLAC	1257..1289	CDD:370061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900