DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MATN2 and matn4

DIOPT Version :9

Sequence 1:	NP_002371.3	Gene:	MATN2 / 4147	HGNCID:	6908	Length:	956	Species:	Homo sapiens
Sequence 2:	XP_005155921.1	Gene:	matn4 / 497348	ZFINID:	ZDB-GENE-050208-64	Length:	944	Species:	Danio rerio

Alignment Length:	1019	Identity:	422/1019 - (41%)
Similarity:	575/1019 - (56%)	Gaps:	171/1019 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    17 VLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIV 81
            |:...|||.:|.                   |..|::...|||||||.||||..|::..:::|::
Zfish    14 VMAATEARPKSG-------------------EPKCKSGPVDLVFIIDGSRSVRPHEFETMRKFMI 59

Human    82 DILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNI 146
            ||:..||||...||:|::||.|.|:|.||||.|.:..::.:|:..:..|:.||||||||:||:|:
Zfish    60 DIIHELDIGLAATRIGVVQYSSQVQNVFSLKAFSKTEQMVKAINEIIPLAQGTMTGLAIRYAMNV 124

Human   147 AFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEP 211
            |||..|||||   |||.|.:|||||||||.||||||.||::||.|:|:||.:.|..:|:::.|.|
Zfish   125 AFSAEEGARP---NVPHVAVIVTDGRPQDRVAEVAAAARESGIEIYAVGVARADMTSLRAMASPP 186

Human   212 HEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTT 276
            .|||||||.:|..|......||.|||...:|...:|.|.|.|.:.||||.|.|..||.||.|..|
Zfish   187 FEDHVFLVESFDLIHQFGLQFQDKLCGMDLCLESDHGCEHICESSPGSYQCLCLPGYTLNEDGKT 251

Human   277 CRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGS 341
            |...||||...|:|||:|:..||||.|.|.:||.|.:|.|.|..:|||:..|..|||:||:....
Zfish   252 CTPIDLCAEGKHDCEQICIASPGSFTCDCNTGYTLNDDKKTCKMIDYCSFGNDSCEHKCVSVLNG 316

Human   342 YLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHC------------------- 387
            :.|:|.||::||.|.||||.||||:..|..|:||||:...|:.|.|
Zfish   317 FNCRCDEGYSLNEDLKTCTMIDYCSFGNDSCEHECVSVLQSFYCQCRDGYTLNEDETTCTMIDYC 381

Human   388 -------------------------------------------------------LKGF------ 391
                                                                   ||||
Zfish   382 SFGNDSCEHECVSVLNGFHCRCNEGYSLNDDLKTCTMIDYCSFGNDSCEHECVSVLKGFHCRCND 446

Human   392 --TLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC 454
              |||.|||||..|:||:.....||||||::.:.::|.|:.||:|:.:.|||:.:|:|:..:..|
Zfish   447 GYTLNDDKKTCTMIDYCSFGNDSCEHECVSVLKGFHCICNEGYSLNDDKKTCTMIDYCSFGNDSC 511

Human   455 EQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSD 519
            |..|::....|.|.|::|:.:|:|.|||:.:|||...:..||:.||::.:.|.|:|.||:.|..|
Zfish   512 EHECVSVLKGFHCICNDGYSLNDDKKTCTMIDYCSFGNDSCEHQCVSVLKGFNCRCNEGYSLNGD 576

Human   520 GKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNS 584
            .|||..:|.|:.|:..|||.|||..:.|.|:|.:||.|.||.|||...|.|...:|.|:|.||:.
Zfish   577 LKTCTMIDYCSFGNDSCEHECVSVLNGFHCRCKDGYTLNEDKKTCTMIDYCSFGNHSCDHHCVSV 641

Human   585 DDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKC 649
            .:.:.|.|.||:.|.||||.|:..::|.:..||||:.||:...||.|.|.||.||.:||:.|..|
Zfish   642 LNGFFCRCNEGYTLQEDGKTCQSDNLCNTVEHGCEYQCVSTPGSYHCICPEGHVLQDDGKSCGTC 706

Human   650 TEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNS 714
            ....||||.:||||||:..:|||:|||||..::|.|.:|.|..||||:|||::|.|||.|..::|
Zfish   707 RTSNIDLVLLIDGSKSVRPQNFELVKQFVNQVVDQLDVSAKGTRVGLVQYSSRVRTEFPLSMYHS 771

Human   715 AKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWA 779
            ..::||||.:::||.||:|||||||||.|.||::.|||||....:||..:||||||:|||:.|||
Zfish   772 KDEIKKAVMNVEYMEKGTMTGLALKHMVENSFSEAEGARPAEKNIPRVGLVFTDGRSQDDIQEWA 836

Human   780 SKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGR 844
            .|||..||||||||||||:|:||:||||:|..||.||:.||:.:.:|:|.||..:|.|....|
Zfish   837 KKAKEAGITMYAVGVGKAVEDELREIASDPVEKHFFYSADFTAISQIAENLKLNVCAAESKGD-- 899

Human   845 QDSPAGELPKTVQQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLLRSTQKLSHSTKPSGSPL 909
                                                                            :
Zfish   900 ----------------------------------------------------------------I 900

Human   910 EEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRL 953
            |.| |.|.||:|:.||.:....:.:|.|:|..||:|:|.||.:|
Zfish   901 EVK-DPCACESLVEFQQVTMSTIEQLNQKLSAMTKRLEVLEKQL 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MATN2	NP_002371.3	vWA_Matrilin	54..276	CDD:238752	114/221 (52%)
		FXa_inhibition	283..318	CDD:291342	18/34 (53%)
		FXa_inhibition	324..359	CDD:291342	15/34 (44%)
		FXa_inhibition	365..400	CDD:291342	20/116 (17%)
		FXa_inhibition	406..441	CDD:291342	13/34 (38%)
		vWFA	<438..481	CDD:294047	14/42 (33%)
		FXa_inhibition	488..523	CDD:291342	13/34 (38%)
		vWFA	<520..563	CDD:294047	20/42 (48%)
		vWFA	<561..603	CDD:294047	17/41 (41%)
		vWFA	<602..644	CDD:294047	19/41 (46%)
		vWA_Matrilin	652..892	CDD:238752	110/239 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..863		1/22 (5%)
		Matrilin_ccoil	911..953	CDD:287378	17/41 (41%)
matn4	XP_005155921.1	vWFA	32..251	CDD:294047	114/221 (52%)
		FXa_inhibition	258..293	CDD:291342	18/34 (53%)
		FXa_inhibition	299..334	CDD:291342	15/34 (44%)
		FXa_inhibition	340..375	CDD:291342	10/34 (29%)
		FXa_inhibition	381..416	CDD:291342	0/34 (0%)
		FXa_inhibition	422..457	CDD:291342	10/34 (29%)
		vWFA	<454..497	CDD:294047	18/42 (43%)
		FXa_inhibition	504..539	CDD:291342	11/34 (32%)
		vWFA	<536..579	CDD:294047	17/42 (40%)
		FXa_inhibition	586..621	CDD:291342	17/34 (50%)
		vWFA	<618..661	CDD:294047	18/42 (43%)
		vWFA	<659..702	CDD:294047	20/42 (48%)
		vWFA	711..944	CDD:294047	129/300 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I34837
eggNOG	1	0.900	-	-		E33208_3BA2W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20538
Inparanoid	1	1.050	817	1.000	Inparanoid score	I3359
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG44890
OrthoDB	1	1.010	-	-		D192390at7742
OrthoFinder	1	1.000	-	-		FOG0000900
OrthoInspector	1	1.000	-	-		oto50100
orthoMCL	1	0.900	-	-		OOG6_106945
Panther	1	1.100	-	-	O	PTHR24020
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2658
SonicParanoid	1	1.000	-	-		X1618
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910