DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and AT1G72700

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	NP_001322799.1	Gene:	AT1G72700 / 843602	AraportID:	AT1G72700	Length:	1228	Species:	Arabidopsis thaliana

Alignment Length:	1485	Identity:	485/1485 - (32%)
Similarity:	710/1485 - (47%)	Gaps:	346/1485 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLT 272
            :|.:||:.|::|:|.||.|.:|.|||.|.||.|||...:|.:.| :|.....:...||:.|:.|:
plant    57 RYRSNYVSTTRYNLITFFPKSLYEQFHRAANLYFLVAAILSVFP-LSPFNKWSMIAPLVFVVGLS 120

  Fly   273 AVKDAYDDIQRHISDSQVNNRKSKTLR-NGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSE 336
            .:|:|.:|.:|.:.|.::|.||:...: :|...:.||.:|.|||:::::.::|..||.||||:|.
plant   121 MLKEALEDWRRFMQDVKINARKTCVHKSDGVFRQRKWKKVSVGDIVKVEKDEFFPADLLLLSSSY 185

  Fly   337 PNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQ 401
            .:|:|::||..||||||||.|:.|..::.|.| .:|..||...|.||.||..|..|.|.|.:..|
plant   186 EDGICYVETMNLDGETNLKVKRSLEVSLPLDD-DESFKNFMATIRCEDPNPNLYTFVGNLEFERQ 249

  Fly   402 RFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLV 466
            .|.||..:||||...||||.:.||||||.|.|||:||||.|:..|.:.::|.:::||..:::.|:
plant   250 TFPLDPSQILLRDSKLRNTTYVYGVVVFTGFDTKVMQNSTKSPSKRSRIERTMDYIIYTLLVLLI 314

  Fly   467 SICALFAIGCAIWEGLIGQHFQLYL-PWEHIIPKDYI-PTGATVIGLLVFFSYAIVLNTVVPISL 529
            .|..:.:.|.| ||.........|| |.|   |.|:. |......|::...:..::...::||||
plant   315 LISCISSSGFA-WETEFHMPKMWYLRPGE---PIDFTNPINPIYAGVVHLITALLLYGYLIPISL 375

  Fly   530 YVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKC 594
            |||:||::..|:..||.|..||...:...|.|||:.|||||||:..|.||||||||.|.|.|.||
plant   376 YVSIEVVKVWQASFINQDLHMYDDESGVPANARTSNLNEELGQVHTILSDKTGTLTCNQMDFLKC 440

  Fly   595 SINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAK 659
            ||.|.|||    :|:.| ||:..                                        ||
plant   441 SIAGTSYG----VRSSE-VEVAA----------------------------------------AK 460

  Fly   660 KTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSA--PSRSQDADAGRLSPRLD 722
            :.::.:...||   :...|:|..:                  .|..  .||:|:.:       ::
plant   461 QMAVDLEEHGE---ISSTPQSQTK------------------VYGTWDSSRTQEIE-------VE 497

  Fly   723 GSGGLSPP------VGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSS 781
            |....:.|      .|.|:.|:..|
plant   498 GDNNYNTPRAPIKGFGFEDNRLMNG---------------------------------------- 522

  Fly   782 HNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNW--SSSPH 844
                                                                    ||  .|.|:
plant   523 --------------------------------------------------------NWLRESQPN 531

  Fly   845 RVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVD--GKLEYQ 907
            .:  ||                                  |||:||:|||.:.|..:  ||..|:
plant   532 DI--LQ----------------------------------FFRILAICHTAIPELNEETGKYTYE 560

  Fly   908 AQSPDEAALVSAARNFGFVFRTRTPNSITIEV----MGQ--TEEYELLNILDFNNVRKRMSVILR 966
            |:|||||:.::|||.|||.|..||.:|:.|..    .||  ..||::||:|:|.:.||||:||:|
plant   561 AESPDEASFLAAAREFGFEFFKRTQSSVFIRERFSGSGQIIEREYKVLNLLEFTSKRKRMTVIVR 625

  Fly   967 RGDSMV-LYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSR 1030
            ..:..: |.|||||::|::||....:.....|..||.::...||||||||.|:|.|..|..|.|.
plant   626 DEEGQILLLCKGADSIIFERLAKNGKTYLGPTTRHLTEYGEAGLRTLALAYRKLDEDEYAAWNSE 690

  Fly  1031 QQEAALSMDS-REQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQ 1094
            ..:|..|:.| |::.|....:.||.|:.|:|.||:|||||.|||:.|..|..||:|:|||||||.
plant   691 FLKAKTSIGSDRDELLETGADMIEKELILIGATAVEDKLQKGVPQCIDKLAQAGLKLWVLTGDKM 755

  Fly  1095 ETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNM 1159
            |||||||::|.||...:..:.|...||....:...|..||:|
plant   756 ETAINIGFACSLLRQGMRQICITSMNSEGGSQDSKRVVKENI----------------------- 797

  Fly  1160 DPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDG 1224
                  :.|.:..:|...|                                       ||
plant   798 ------LNQLTKAVQMVKL---------------------------------------EK----- 812

  Fly  1225 GTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAK 1289
                   |.:..|||:::|.:|.:.|..:::.:||.:|..|.:||||||:|.||||||.|:|...
plant   813 -------DPHAAFALIIDGKTLTYALEDDMKYQFLALAVDCASVICCRVSPKQKALVVRLVKEGT 870

  Fly  1290 NAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCK 1354
            ...|||||||||||.||:.|.|||||||.||:|||::||:||||||:|||||:|||.|.|.|:.:
plant   871 GKTTLAIGDGANDVGMIQEADIGVGISGVEGMQAVMASDFSIAQFRFLERLLVVHGHWCYKRIAQ 935

  Fly  1355 FLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLE 1419
            .:.||||||.||.|...::..|.|||.|:|::..::.::|:..|||||:||||||||||.:..|:
plant   936 MICYFFYKNIAFGLTLFYFEAFTGFSGQSVYNDYYLLLFNVVLTSLPVIALGVFEQDVSSEICLQ 1000

  Fly  1420 FPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYG-VYKDGVSANGFVVSDHMTLGAVVAT 1483
            ||.||..|.|:..|:....:..:.:|.:.|||:|.:..| :|......|| ..:|...:|..:.|
plant  1001 FPALYQQGTKNLFFDWSRILGWMCNGVYASLVIFFLNIGIIYSQAFRDNG-QTADMDAVGTTMFT 1064

  Fly  1484 ILIVDNTAQISLYTSYWTVVNHVTIWGSL-VWY-FVLDYFYNYVIGGPYVGSLTQAMKDL----- 1541
            .:|.....||:|..|::|.:.||.||||: :|| ||..|   .::...|.|::.:.:.::
plant  1065 CIIWAANVQIALTMSHFTWIQHVLIWGSIGMWYLFVAIY---SMMPPSYSGNIYRILDEILAPAP 1126

  Fly  1542 TFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRR-TASSRRGRRSV 1605
            .:|:..|:..:|.|.|.:|:..:...::| |...|.|:.  |.:.|...|.|. |....:.|...
plant  1127 IYWMATLLVTVAAVLPYVAHIAFQRFLNP-LDHHIIQEI--KYYGRDIEDARLWTRERTKAREKT 1188

  Fly  1606 RSGYAFAHQEGFGRLITSGKIMHKLPQDFAFPLGLGTKKTQVLHNNLNSADGPNS 1660
            :.|:...         ...||.|...:       |..|::.:.|.:...|..|.|
plant  1189 KIGFTAR---------VDAKIRHLRSK-------LNKKQSNLSHFSAQDAMSPRS 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	22/51 (43%)
		Cation_ATPase	891..985	CDD:289987	46/102 (45%)
		HAD_like	<1261..1324	CDD:304363	41/62 (66%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	96/254 (38%)
AT1G72700	NP_001322799.1	ATPase-Plipid	58..1163	CDD:273734	468/1400 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	235	1.000	Domainoid score	I621
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.730