DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and Atp9a

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	XP_038962655.1	Gene:	Atp9a / 84011	RGDID:	621421	Length:	1047	Species:	Rattus norvegicus

Alignment Length:	1515	Identity:	359/1515 - (23%)
Similarity:	560/1515 - (36%)	Gaps:	536/1515 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 QPERRNSDLEGSPRACLAQPEGMNIGSSTQTIATPLMIGDSFYSLAPGGGNPPPNKSDDQELYKQ 159
            ||.|....::..|||                       |...:....|||.|.|.
  Rat     8 QPVRHKKRVDSRPRA-----------------------GCCEWLRCCGGGEPRPR---------- 39

  Fly   160 RDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTF 224
                                      :.:....|:|.:          :|..|.|...||:.|||
  Rat    40 --------------------------TVWLGHPEKRDQ----------RYPRNVINNQKYNFFTF 68

  Fly   225 LPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQ 289
            ||..|..||:...|||||.|...|.:|.:......|..:||..||.:|.:::|.::|:.:|.|.:
  Rat    69 LPGVLFSQFRYFFNFYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTIIREAVEEIRCYIRDKE 133

  Fly   290 VNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNL 354
            :|::....|.:...|:.|.|.:||||:|.::.||.|.||.:.|.|||.||.||:.|.:|||||:.
  Rat   134 MNSQIYSRLTSRGTVKVKSSNIQVGDLILVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDW 198

  Fly   355 KAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRN 419
            |.:..:..|..|....| |......:..|.||..::.|.||....      |::..:.....:.|
  Rat   199 KLRLPVACTQRLPTAAD-LLQIRSYVYAEEPNIDIHNFLGTFTRE------DSDPPISESLSIEN 256

  Fly   420 TQWC---------YGVVVFAGVDTKLMQNSGKTQFKSTGVD---RLLNFIIIG--IVLFLVSICA 470
            |.|.         .|||::.|.:.:.:.|:...:.|....|   ..|..|:.|  :|:.||.:..
  Rat   257 TLWAGTVIASGTVVGVVLYTGRELRSVMNTSDPRSKIGLFDLEVNCLTKILFGALVVVSLVMVAL 321

  Fly   471 LFAIGCAIWEGLIGQHF--QLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSV 533
                          |||  :.||               .:|..|:.||      .::||||.|::
  Rat   322 --------------QHFAGRWYL---------------QIIRFLLLFS------NIIPISLRVNL 351

  Fly   534 EVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSING 598
            ::.:.|.|::|..|.::  |.|    ..|::|:.|:||:|.|:.:|||||||||.|.|.:..:..
  Rat   352 DMGKIVYSWVIRRDSKI--PGT----VVRSSTIPEQLGRISYLLTDKTGTLTQNEMVFKRLHLGT 410

  Fly   599 RSYG-DVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTS 662
            .:|| |.:|       |:  |..||              :|...|:..||          |:|..
  Rat   411 VAYGLDSMD-------EV--QSHIF--------------SIYTQPSQDPP----------AQKGP 442

  Fly   663 MVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGL 727
            .|.|
  Rat   443 TVTT------------------------------------------------------------- 446

  Fly   728 SPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRF 792
                                                                         |:|
  Rat   447 -------------------------------------------------------------KVR- 449

  Fly   793 KKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSAN 857
                                       .|:|:                    |||
  Rat   450 ---------------------------RTMSS--------------------RVH---------- 457

  Fly   858 PHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTV-----------MAET----VDGKLEYQ 907
                           :||::           :||||.|           .||.    .|....||
  Rat   458 ---------------EAVKA-----------IALCHNVTPVYECNGVTDQAEAEKQFEDSCRVYQ 496

  Fly   908 AQSPDEAALVSAARNFGFVFRTRTPNSITIEVMG-QTEEYELLNILDFNNVRKRMSVILRRGDS- 970
            |.||||.|||....:.|.....|..:|:.:...| |.....:|.:..|....|||.:|:|...:
  Rat   497 ASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNLTILQVFPFTYESKRMGIIVRDESTG 561

  Fly   971 -MVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEA 1034
             :..|.||||.|:     .|........::.....|.||||.|.:|::.|||:.|.|:.:|..:|
  Rat   562 EITFYMKGADVVM-----AGIVQYNDWLEEECGNMAREGLRVLVVAKKSLTEEQYQDFEARYVQA 621

  Fly  1035 ALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAIN 1099
            .||:..|..|:..:.|.:|.||:|:.:|.:||:||..|..::..|:|||||:|:|||||.|||..
  Rat   622 KLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATC 686

  Fly  1100 IGYSCQLLT-DELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLS 1163
            ...:..|:| ::...||.:..|. .|...:|..|:.
  Rat   687 TAKNAHLVTRNQDIHVFRLVTNR-GEAHLELNAFRR----------------------------- 721

  Fly  1164 VTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTAS 1228
                                                        ..:|
  Rat   722 --------------------------------------------KHDC----------------- 725

  Fly  1229 IVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVT 1293
                     |||::|.||..||. ..|.:|:::|.||.||:|||..|.|||.:|.|::.....:|
  Rat   726 ---------ALVISGDSLEVCLK-YYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLT 780

  Fly  1294 LAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRY 1358
            .|:|||.||||||:.:..|||:.|:||.||.|::|:||.||::|.|||:||||.||.|.....::
  Rat   781 CAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSAALSQF 845

  Fly  1359 FFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRL 1423
            ..:::...:.....:|....|::..::....|..|:..||..||.:| |.::||..:.::.:|.|
  Rat   846 VIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSL-VLDKDVKSEVAMLYPEL 909

  Fly  1424 YTPGLKSELFNIREF-------IY---SVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLG 1478
            |...||....:.:.|       ||   ::::||   |:||                 .|:.:.:.
  Rat   910 YKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGA---LLLF-----------------ESEFVHIV 954

  Fly  1479 AVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGSLTQAMKDLTF 1543
            |:..|.||:.....::|....|..:..|....||..|.....|.:..|...::.:|:      ..
  Rat   955 AISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLS------FL 1013

  Fly  1544 WVTMLITVMALVAPVLAYKF 1563
            |...:||:::.: |:...|:
  Rat  1014 WKVSVITLVSCL-PLYVLKY 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	22/64 (34%)
		Cation_ATPase	891..985	CDD:289987	35/111 (32%)
		HAD_like	<1261..1324	CDD:304363	32/62 (52%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	61/250 (24%)
Atp9a	XP_038962655.1	P-type_ATPase_APLT_Neo1-like	55..967	CDD:319841	330/1325 (25%)
Atp9a	XP_038962655.1	Cation_ATPase	464..571	CDD:404183	33/106 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.020