DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and AT1G17500

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	NP_001319028.1	Gene:	AT1G17500 / 838324	AraportID:	AT1G17500	Length:	1216	Species:	Arabidopsis thaliana

Alignment Length:	1443	Identity:	479/1443 - (33%)
Similarity:	707/1443 - (48%)	Gaps:	330/1443 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 RRIRANDKEFNAQ--FKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSL 256
            |.:..|....:.:  .||.:||:.|::|:|.||.|..|.|||.|.||||||...:|.:.| :|..
plant    41 RTVYCNQPHMHKKKPLKYRSNYVSTTRYNLITFFPKCLYEQFHRAANFYFLVAAILSVFP-LSPF 104

  Fly   257 TPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLR-NGKLVEAKWSEVQVGDVIRLD 320
            ...:...||:.|:.|:.:|:|.:|..|.:.|.::|..|....: :|:....||.::.|||:::::
plant   105 NKWSMIAPLVFVVGLSMLKEALEDWSRFMQDVKINASKVYVHKSDGEFRRRKWKKISVGDIVKVE 169

  Fly   321 NNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERP 385
            .:.|..||.||||:|..:|:|::||..||||||||.|:.|..|:.|.| :||..:|.|.|.||.|
plant   170 KDGFFPADLLLLSSSYEDGICYVETMNLDGETNLKVKRSLEVTLSLDD-YDSFKDFTGIIRCEDP 233

  Fly   386 NNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGV 450
            |..|..|.|.|.:..|.|.||..:||||...||||.:.||||||.|.|||:||||.|:..|.:.:
plant   234 NPSLYTFVGNLEYERQIFPLDPSQILLRDSKLRNTPYVYGVVVFTGHDTKVMQNSTKSPSKRSRI 298

  Fly   451 DRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLP-WEHIIPKD----YIPTGATVIG 510
            ::.:::||..:::.|:.|..:.:.|.| ||      .:.::| |.::.|::    ..|:.....|
plant   299 EKTMDYIIYTLLVLLILISCISSSGFA-WE------TKFHMPKWWYLRPEEPENLTNPSNPVYAG 356

  Fly   511 LLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQY 575
            .:...:..::...::|||||||:||::.:|:..||.|..||...:...|.|||:.|||||||:..
plant   357 FVHLITALLLYGYLIPISLYVSIEVVKVLQASFINKDLHMYDSESGVPAHARTSNLNEELGQVDT 421

  Fly   576 IFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVA 640
            |.||||||||.|.|.|.||||.|.|||    :|:.| ||:...|.:
plant   422 ILSDKTGTLTCNQMDFLKCSIAGTSYG----VRSSE-VEVAAAQQM------------------- 462

  Fly   641 PPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSA 705
                  .:.|....||.::      ||:..||.      .|||     :::|
plant   463 ------AVDLDEHGEVSSR------TSTPRAQA------RDIE-----VESS------------- 491

  Fly   706 PSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQ 770
                       ::||:...|     .|.|:.|:..|
plant   492 -----------ITPRIPIKG-----FGFEDIRLMDG----------------------------- 511

  Fly   771 QTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAF 835

plant   512 ----------------------------------------------------------------- 511

  Fly   836 ATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETV 900
              ||...||.                      |..||            |||:||:|||.:.|..
plant   512 --NWLREPHT----------------------DDILL------------FFRILAICHTAIPELN 540

  Fly   901 D--GKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEV----MGQT--EEYELLNILDFNNV 957
            :  ||..|:|:|||||:.::||..|||||..||.:|:.:..    .|||  .||::||:|||.:.
plant   541 EETGKYTYEAESPDEASFLTAASEFGFVFFKRTQSSVYVHERLSHSGQTIEREYKVLNLLDFTSK 605

  Fly   958 RKRMSVILRRGDSMV-LYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTE 1021
            ||||||::|..:..: |.|||||::|::||....:.....|..|||::...|||||||:.|:|.|
plant   606 RKRMSVVVRDEEGQILLLCKGADSIIFERLAKNGKVYLGPTTKHLNEYGEAGLRTLALSYRKLDE 670

  Fly  1022 QYYNDWRSRQQEAALSMDS-REQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIK 1085
            :.|:.|.:...:|..|:.| |::.|..|.:.||.::.|||.||:|||||.|||:.|..|..||:|
plant   671 EEYSAWNAEFHKAKTSIGSDRDELLERISDMIEKDLILVGATAVEDKLQKGVPQCIDKLAQAGLK 735

  Fly  1086 IWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPF 1150
            :|||||||.||||||||||.||...:..:.|...|| |...:..:..|::|
plant   736 LWVLTGDKMETAINIGYSCSLLRQGMKQICITVVNS-EGASQDAKAVKDNI-------------- 785

  Fly  1151 DRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLF 1215
                           :.|.:..:|...|
plant   786 ---------------LNQITKAVQMVKL------------------------------------- 798

  Fly  1216 GDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKAL 1280
              ||            |.:..|||:::|.:|.:.|..|::.:||.:|..|.:||||||:|.||||
plant   799 --EK------------DPHAAFALIIDGKTLTYALEDEMKYQFLALAVDCASVICCRVSPKQKAL 849

  Fly  1281 VVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHG 1345
            |..|:|.....:|||||||||||.||:.|.|||||||.||:|||::||:||||||:|||||:|||
plant   850 VTRLVKEGTGKITLAIGDGANDVGMIQEADIGVGISGVEGMQAVMASDFSIAQFRFLERLLVVHG 914

  Fly  1346 RWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQ 1410
            .|.|.|:.:.:.||||||.||.|...::..|.|||.|:|::..::.::|:..|||||:|||||||
plant   915 HWCYKRIAQMICYFFYKNIAFGLTLFYFEAFTGFSGQSVYNDYYLLLFNVVLTSLPVIALGVFEQ 979

  Fly  1411 DVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYG-VYKDGVSANGFVVSDH 1474
            |||.:..|:||.||..|.|:..|:....:..:.:|.::|||:|.:..| :|:.....:| ..:|.
plant   980 DVSSEICLQFPALYQQGKKNLFFDWYRILGWMGNGVYSSLVIFFLNIGIIYEQAFRVSG-QTADM 1043

  Fly  1475 MTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSL-VWY-FVLDYFYNYVIGGPYVGSLTQA 1537
            ..:|..:.|.:|.....||:|..|::|.:.||.||||: :|| ||..|   .::.....|::.:.
plant  1044 DAVGTTMFTCIIWAVNVQIALTVSHFTWIQHVLIWGSIGLWYLFVALY---GMMPPSLSGNIYRI 1105

  Fly  1538 MKDL-----TFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRR-TA 1596
            :.::     .:|:...:..:..|.|..|:..:...:|| |...|.|:.  |.:.|...|.|. |.
plant  1106 LVEILAPAPIYWIATFLVTVTTVLPYFAHISFQRFLHP-LDHHIIQEI--KYYKRDVEDRRMWTR 1167

  Fly  1597 SSRRGRRSVRSGY 1609
            ...:.|...:.|:
plant  1168 ERTKAREKTKIGF 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	25/66 (38%)
		Cation_ATPase	891..985	CDD:289987	47/102 (46%)
		HAD_like	<1261..1324	CDD:304363	40/62 (65%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	93/254 (37%)
AT1G17500	NP_001319028.1	ATPase-Plipid	58..1151	CDD:273734	468/1393 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	235	1.000	Domainoid score	I621
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.730