DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and ALA2

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	NP_568633.2	Gene:	ALA2 / 834447	AraportID:	AT5G44240	Length:	1139	Species:	Arabidopsis thaliana

Alignment Length:	1433	Identity:	379/1433 - (26%)
Similarity:	604/1433 - (42%)	Gaps:	439/1433 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 RRIRANDKEFNA--------QFKYHN-----------NYIKTSKYSLFTFLPFNLLEQFQRLANF 239
            |..|.|||..:.        :|.|.|           |.|...||:|:.|||.||.|||.|..|.
plant    15 RDFRRNDKLIDVFEFLPDLDRFVYINDDEASKELCCDNRISNRKYTLWNFLPKNLWEQFSRFMNQ 79

  Fly   240 YFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNG--K 302
            |||.:..|||...|:.:.|.:|..|||.:..::|.|:|:||..|::||.:.|.::...::.|  |
plant    80 YFLLIACLQLWSLITPVNPASTWGPLIFIFAVSASKEAWDDYHRYLSDKKANEKEVWIVKQGIKK 144

  Fly   303 LVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAK----QCLTET 363
            .::|:  ::|||:::.|..|..|..|.:||.||:|.|:|::|||.|||||:||.:    .|:...
plant   145 HIQAQ--DIQVGNIVWLRENDEVPCDLVLLGTSDPQGVCYVETAALDGETDLKTRVIPSACVGID 207

  Fly   364 IELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRFA--LDNE-------KILLRGCVLRN 419
            :||      |....|.|.|..|:..:.:||..:    :.|.  :||:       ..||:.|.|||
plant   208 LEL------LHKMKGVIECPVPDKDIRRFDANM----RLFPPFIDNDVCSLTIKNTLLQSCYLRN 262

  Fly   420 TQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIG 484
            |:|..||.|:.|..|||..:.|..:.|.|.:|.:::.:...|.:|.:.:..:..|...:|:....
plant   263 TEWACGVSVYTGNQTKLGMSRGIAEPKLTAMDAMIDKLTGAIFVFQIVVVLVLGIAGNVWKDTEA 327

  Fly   485 QHFQLYL------PWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFL 543
            :. |.|:      ||..:              |::...:.::.:.::|||:.||:::::.:.:..
plant   328 RK-QWYVQYPEEAPWYEL--------------LVIPLRFELLCSIMIPISIKVSLDLVKGLYAKF 377

  Fly   544 INWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLR 608
            |.||.||....|.|.:.|..|.::|:|||::||.:|||||||.|.|.|.:|.|.|..||
plant   378 IEWDVEMIDQETGTASYAANTAISEDLGQVEYILTDKTGTLTDNKMIFRRCCIGGIFYG------ 436

  Fly   609 TGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQV 673
                           |.|                                          |:|
plant   437 ---------------NEN------------------------------------------GDA-- 442

  Fly   674 LPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRI 738

plant   443 ----------------------------------------------------------------- 442

  Fly   739 SGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGV 803
                                       |.|:|
plant   443 ---------------------------LKDAQ--------------------------------- 447

  Fly   804 VISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYD 868

plant   448 ----------------------------------------------------------------- 447

  Fly   869 RTLLDAVRSDEEHSHVFFRLLALCHTVM-AETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTP 932
              ||:|:.|.......|..::|:|:||: .::..|.:.|:|||.||.|||.||.....||..:..
plant   448 --LLNAITSGSTDVIRFLTVMAICNTVLPVQSKAGDIVYKAQSQDEDALVIAASKLHMVFVGKNA 510

  Fly   933 NSITIEVMGQTEEYELLNILDFNNVRKRMSVILR--RGDSMVLYCKGADNVIYDRLHGGQEDLKA 995
            |.:.|...|....||:|.||:|.:.||||||:::  :...::|..||||..|......||:   .
plant   511 NLLEIRFNGSVIRYEVLEILEFTSDRKRMSVVVKDCQNGKIILLSKGADEAILPYARAGQQ---T 572

  Fly   996 RT-QDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLV 1059
            || .|.:..::..|||||.||.|.|.|..|.:|..:.:||:..:..||.::..:.:.:|.::.::
plant   573 RTIGDAVEHYSQLGLRTLCLAWRELEENEYLEWSVKFKEASSLLVDREWRIAEVCQRLEHDLYIL 637

  Fly  1060 GVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDE-LADVFIVDGNSVE 1123
            |||||||:||||||::|..|:.|||..|:||||||.|||.|..||..::.| ...:.::||.:.|
plant   638 GVTAIEDRLQDGVPETIETLRKAGINFWMLTGDKQNTAIQIALSCNFISPEPKGQLLMIDGKTEE 702

  Fly  1124 EVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAI 1188
            :|.:.|.:.
plant   703 DVSRSLERV-------------------------------------------------------- 711

  Fly  1189 SVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPE 1253
             ::|.|                                  |...|....|.|::|.:|...|...
plant   712 -LLTMR----------------------------------ITASEPKDVAFVIDGWALEIALKHH 741

  Fly  1254 LENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQ 1318
            .:: |:::|...:..|||||||.|||.:||::|.. :..|||||||.|||.||:.|.|||||||:
plant   742 RKD-FVELAILSRTAICCRVTPSQKAQLVEILKSC-DYRTLAIGDGGNDVRMIQQADIGVGISGR 804

  Fly  1319 EGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQT 1383
            |||||..::||||.:||:|:||:|||||:||.|.....:|.|||:........::|...|.|..:
plant   805 EGLQAARAADYSIGRFRFLKRLILVHGRYSYNRTAFLSQYSFYKSLLICFIQIFFSFISGVSGTS 869

  Fly  1384 VFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFT 1448
            :|:.:.:..||:||||:||| :.|.::|:|:.:.::.|::........|.|...|........|.
plant   870 LFNSVSLMAYNVFYTSVPVL-VSVIDKDLSEASVMQHPQILFYCQAGRLLNPSTFAGWFGRSLFH 933

  Fly  1449 SLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLV 1513
            ::::|:|.       :.|..:..|:...||.|..:..|......::..|:.:||:.|::|||:||
plant   934 AIIVFVIT-------IHAYAYEKSEMEELGMVALSGCIWLQAFVVAQETNSFTVLQHLSIWGNLV 991

  Fly  1514 WYFVLDYFYNYVIGGPYVGSLT---QAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDK 1575
            .::.:::.::.:   |..|..|   :.....::|:||.:.|.|.:.|:.|.|::.....||..:.
plant   992 GFYAINFLFSAI---PSSGMYTIMFRLCSQPSYWITMFLIVGAGMGPIFALKYFRYTYRPSKINI 1053

  Fly  1576 IRQ 1578
            ::|
plant  1054 LQQ 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	30/83 (36%)
		Cation_ATPase	891..985	CDD:289987	38/96 (40%)
		HAD_like	<1261..1324	CDD:304363	38/62 (61%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	70/249 (28%)
ALA2	NP_568633.2	PhoLip_ATPase_N	37..100	CDD:292826	25/62 (40%)
		ATPase-Plipid	50..1056	CDD:273734	370/1396 (27%)
		E1-E2_ATPase	105..>193	CDD:278548	35/89 (39%)
		Cation_ATPase	469..565	CDD:289987	38/95 (40%)
		HAD_like	<762..799	CDD:304363	21/37 (57%)
		PhoLip_ATPase_C	810..1049	CDD:292829	70/249 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830