DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and AT3G13900

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	NP_188006.4	Gene:	AT3G13900 / 820603	AraportID:	AT3G13900	Length:	1243	Species:	Arabidopsis thaliana

Alignment Length:	1515	Identity:	500/1515 - (33%)
Similarity:	729/1515 - (48%)	Gaps:	372/1515 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 RRLSQIRRRRSSYY-FS-------ENE-----------RRIRANDKEFNAQ--FKYHNNYIKTSK 218
            ||..:.|.|:|.:| |.       |::           |.:..|....:..  .:|.:||:.|::
plant     3 RRRIRSRIRKSHFYTFKCLRPKTLEDQGPHIINGPGYTRIVHCNQPHLHLAKVLRYTSNYVSTTR 67

  Fly   219 YSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQR 283
            |:|.||||..|.|||.|:||||||...:|.:.| :|.....:...|||.|:.|:..|:|.:|.:|
plant    68 YNLITFLPKCLYEQFHRVANFYFLVAAILSVFP-LSPFNKWSMIAPLIFVVGLSMGKEALEDWRR 131

  Fly   284 HISDSQVNNRKSKTLR-NGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAE 347
            .:.|.:||:||:...| :|.....||.:::||||::::.:||..||.||||:|..:|:|::||..
plant   132 FMQDVKVNSRKATVHRGDGDFGRRKWKKLRVGDVVKVEKDQFFPADLLLLSSSYEDGICYVETMN 196

  Fly   348 LDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILL 412
            ||||||||.|:||..|:.| :|.|:..:|:|.|.||.||..|..|.|.|.:.||.:.||..:|||
plant   197 LDGETNLKVKRCLDVTLPL-ERDDTFQSFSGTIKCEDPNPNLYTFVGNLEYDGQVYPLDPSQILL 260

  Fly   413 RGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCA 477
            |...||||.:.||||||.|.|||:||||.|:..|.:.:::.:::||..:...||.:..:.::|.|
plant   261 RDSKLRNTSYVYGVVVFTGHDTKVMQNSTKSPSKRSRIEKRMDYIIYTLFALLVLVSFISSLGFA 325

  Fly   478 IWEGL-IGQHFQLYL----PWEHIIPKDYIPTGATVIGLLVFFSYAIVL-NTVVPISLYVSVEVI 536
            :...: :|..:  ||    |.....|::  |..|.|:.|:.    |::| ..::|||||||:|::
plant   326 VMTKMHMGDWW--YLRPDKPERLTNPRN--PFHAWVVHLIT----AVLLYGYLIPISLYVSIELV 382

  Fly   537 RFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSY 601
            :.:|:..||.|.:||...:.|.|:|||:.|||||||:..|.||||||||.|.|.|.||||.|.||
plant   383 KVLQATFINQDLQMYDSESGTPAQARTSNLNEELGQVDTILSDKTGTLTCNQMDFLKCSIAGTSY 447

  Fly   602 GDVIDLRTGEL---------VEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVH 657
            |    :|..|:         :::.|:    |.....:.|..                   :..:|
plant   448 G----VRASEVELAAAKQMAIDLDEE----QGEEVTHLPRT-------------------RGRMH 485

  Fly   658 AKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLD 722
                       |.|: :|.:..||||              |:.|..:.....|....|     :.
plant   486 -----------GYAK-MPSKTSSDIE--------------LETVITATDEGDQTQSTG-----IK 519

  Fly   723 GSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRL 787
            |       ...|::|:.||
plant   520 G-------FSFEDQRLMGG---------------------------------------------- 531

  Fly   788 VKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSV 852
                                                              ||.:.|:....|
plant   532 --------------------------------------------------NWLNEPNSDDIL--- 543

  Fly   853 DFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVD---GKLEYQAQSPDEA 914
                                           :|.|:||:|||.:.| ||   ||..|:|:||||.
plant   544 -------------------------------MFLRILAVCHTAIPE-VDEDTGKCTYEAESPDEV 576

  Fly   915 ALVSAARNFGFVFRTRTPNSITIEV--MGQ--TEEYELLNILDFNNVRKRMSVILR--RGDSMVL 973
            |.:.||..|||.|..||.:|:.|..  .||  ..||::||:|||.:.|||||||:|  :| .::|
plant   577 AFLVAAGEFGFEFTKRTQSSVFISERHSGQPVEREYKVLNVLDFTSKRKRMSVIVRDEKG-QILL 640

  Fly   974 YCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSM 1038
            .|||||::|::||....::....|..|||.:...|||||||:.|:|.|..|:.|.|...:|..|:
plant   641 LCKGADSIIFERLSKNGKNYLEATSKHLNGYGEAGLRTLALSYRKLDETEYSIWNSEFHKAKTSV 705

  Fly  1039 DS-REQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGY 1102
            .: |::.|..:.:.:|.|:.|||.||:|||||.|||:.|..|..||:|||||||||.||||||||
plant   706 GADRDEMLEKVSDMMEKELILVGATAVEDKLQKGVPQCIDKLAQAGLKIWVLTGDKMETAINIGY 770

  Fly  1103 SCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMT 1167
            :|.||...:..::|...|  ||                               .|:.||.:.  .
plant   771 ACSLLRQGMKQIYIALRN--EE-------------------------------GSSQDPEAA--A 800

  Fly  1168 QTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVD 1232
            :.:..||..|                                 .:.:...||            |
plant   801 RENILMQIIN---------------------------------ASQMIKLEK------------D 820

  Fly  1233 ENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIG 1297
            .:..|||:::|.:|.:.|..:::.:||.:|..|.:||||||:|.|||||..|.|......|||||
plant   821 PHAAFALIIDGKTLTYALEDDIKYQFLALAVDCASVICCRVSPKQKALVTRLAKEGTGKTTLAIG 885

  Fly  1298 DGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYK 1362
            ||||||.||:.|.|||||||.||:|||::||:||||||:|||||:|||.|.|.|:.:.:.|||||
plant   886 DGANDVGMIQEADIGVGISGVEGMQAVMASDFSIAQFRFLERLLVVHGHWCYKRIAQMICYFFYK 950

  Fly  1363 NFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPG 1427
            |..|.|...::..|.|||.|.:::..::.::|:..|||||:||||||||||.:..|:||.||..|
plant   951 NITFGLTLFYFEAFTGFSGQAIYNDSYLLLFNVILTSLPVIALGVFEQDVSSEVCLQFPALYQQG 1015

  Fly  1428 LKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQ 1492
            .|:..|:....|..:.:|.:.|:|:|.:..|::......:|...:|...:|..:.|.:|.....|
plant  1016 PKNLFFDWYRIIGWMANGVYASVVIFSLNIGIFHVQSFCSGGQTADMDAMGTAMFTCIIWAVNVQ 1080

  Fly  1493 ISLYTSYWTVVNHVTIWGSLV-WYFVLDYF--YNYVIGGPYVGSLTQAMKDL-TFWVTMLITVMA 1553
            |:|..|::|.:.||.||||:| ||..|..|  ....:.|.....|::.:... .||:|.|:.:.|
plant  1081 IALTMSHFTWIQHVLIWGSIVTWYIFLALFGMLPPKVSGNIFHMLSETLAPAPIFWLTSLLVIAA 1145

  Fly  1554 LVAPVLAY------------------KFYLLDVHPSL-----SDKIRQKSLKKIHSRASSDVRRT 1595
            ...|.|||                  |.:.:||....     ..|.|:|:...:.:|..:.:|:.
plant  1146 TTLPYLAYISFQRSLNPLDHHIIQEIKHFRIDVQDECMWTRERSKAREKTKIGVTARVDAKIRQL 1210

  Fly  1596 ASSRRGR-------RSVRSG 1608
                |||       .||.||
plant  1211 ----RGRLQRKHSILSVMSG 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	25/66 (38%)
		Cation_ATPase	891..985	CDD:289987	50/102 (49%)
		HAD_like	<1261..1324	CDD:304363	40/62 (65%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	98/268 (37%)
AT3G13900	NP_188006.4	ATPase-Plipid	58..1170	CDD:273734	475/1398 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	178	1.000	Domainoid score	I1064
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.730