DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8B and ATP8B4

DIOPT Version :9

Sequence 1:NP_731669.2 Gene:ATP8B / 41469 FlyBaseID:FBgn0037989 Length:1726 Species:Drosophila melanogaster
Sequence 2:XP_011520348.1 Gene:ATP8B4 / 79895 HGNCID:13536 Length:1257 Species:Homo sapiens


Alignment Length:1515 Identity:659/1515 - (43%)
Similarity:860/1515 - (56%) Gaps:379/1515 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   191 ENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISS 255
            |.||.::|||:|:|.:|:|.:|.|.||||::.||||.||.|||||:||.||||||:|||||.|||
Human    47 EVERIVKANDREYNEKFQYADNRIHTSKYNILTFLPINLFEQFQRVANAYFLCLLILQLIPEISS 111

  Fly   256 LTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLD 320
            ||..||.:||:.|:|:||||||.||..||.||:|||||:|:.|.|.||...||..|:|||:|:|:
Human   112 LTWFTTIVPLVLVITMTAVKDATDDYFRHKSDNQVNNRQSEVLINSKLQNEKWMNVKVGDIIKLE 176

  Fly   321 NNQFVAADTLLLSTSEPNGLCFIETAELDG----------------------------ETNLKAK 357
            ||||||||.||||:|||:|||::|||||||                            |||||.:
Human   177 NNQFVAADLLLLSSSEPHGLCYVETAELDGSLCCYKDVPWVECQLFGAQEALPTFLKQETNLKVR 241

  Fly   358 QCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQW 422
            ..|:.|.|||.....|..|:|.::||.|||.|:||.|.|.|:..:.:|:||||:||||:||||.|
Human   242 HALSVTSELGADISRLAGFDGIVVCEVPNNKLDKFMGILSWKDSKHSLNNEKIILRGCILRNTSW 306

  Fly   423 CYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHF 487
            |:|:|:|||.|||||||||||:||.|.:|||:|.:::.|..||:.:..:.|||.:|||...|..|
Human   307 CFGMVIFAGPDTKLMQNSGKTKFKRTSIDRLMNTLVLWIFGFLICLGIILAIGNSIWESQTGDQF 371

  Fly   488 QLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYY 552
            :.:|.|..      ....:...|.|.|:||.|:|||||||||||||||||...|:.||||.:|||
Human   372 RTFLFWNE------GEKSSVFSGFLTFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDRKMYY 430

  Fly   553 PTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITE 617
            ......|.|||||||||||||:|||||||||||||||||.:||||||.||:|.|           
Human   431 SRKAIPAVARTTTLNEELGQIEYIFSDKTGTLTQNIMTFKRCSINGRIYGEVHD----------- 484

  Fly   618 QQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDI 682
                                                                             
Human   485 ----------------------------------------------------------------- 484

  Fly   683 ERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGA 747
                                        |.|                                  
Human   485 ----------------------------DLD---------------------------------- 487

  Fly   748 GCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHL 812
                                  |:||                               |:|     
Human   488 ----------------------QKTE-------------------------------ITQ----- 494

  Fly   813 DEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRS 877
            ::||                                   ||||.....:.:|:::|..|:::::.
Human   495 EKEP-----------------------------------VDFSVKSQADREFQFFDHHLMESIKM 524

  Fly   878 DEEHSHVFFRLLALCHTVMA-ETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMG 941
            .:...|.|.||||||||||: |...|:|.||.|||||.|||:|||||||:|::|||.:||||.:|
Human   525 GDPKVHEFLRLLALCHTVMSEENSAGELIYQVQSPDEGALVTAARNFGFIFKSRTPETITIEELG 589

  Fly   942 QTEEYELLNILDFNNVRKRMSVILRRGDSMV-LYCKGADNVIYDRLHGGQEDLKARTQDHLNKFA 1005
            ....|:||..|||||.|||||||:|..:..: ||.||||.:::::||...|.|.:.|.|||::||
Human   590 TLVTYQLLAFLDFNNTRKRMSVIVRNPEGQIKLYSKGADTILFEKLHPSNEVLLSLTSDHLSEFA 654

  Fly  1006 GEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQD 1070
            ||||||||:|.|.|.::|:.:|....::|..:.:.|::::..:|||||.::.|:|.||:|||||:
Human   655 GEGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEERDERIAGLYEEIERDLMLLGATAVEDKLQE 719

  Fly  1071 GVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKES 1135
            ||.:::.:|..|.|||||||||||||||||||:|.:|||::.|||::.||:..||.::||:.|: 
Human   720 GVIETVTSLSLANIKIWVLTGDKQETAINIGYACNMLTDDMNDVFVIAGNNAVEVREELRKAKQ- 783

  Fly  1136 IKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNK 1200
                                                                             
Human   784 ----------------------------------------------------------------- 783

  Fly  1201 DNKGGPDSAECNNLFGDEKGSEDGGTA----------SIVVDENTG-FALVVNGHSLVHCLSPEL 1254
                        ||||..:...:|...          |||.:..|| :||::|||||.|.|..::
Human   784 ------------NLFGQNRNFSNGHVVCEKKQQLELDSIVEETITGDYALIINGHSLAHALESDV 836

  Fly  1255 ENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQE 1319
            :|..|::|..||.||||||||||||.||||:|:.:||||||||||||||||||:|||||||||||
Human   837 KNDLLELACMCKTVICCRVTPLQKAQVVELVKKYRNAVTLAIGDGANDVSMIKSAHIGVGISGQE 901

  Fly  1320 GLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTV 1384
            ||||||:||||.||||||:|||||||||||:||||||.|||||||||||.|.|:..|||||||||
Human   902 GLQAVLASDYSFAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTV 966

  Fly  1385 FDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTS 1449
            :|..||:::|:.||||||||:|:|:|||||:||::.|:||.||..:.|||.|:|...||||.:||
Human   967 YDQWFITLFNIVYTSLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYTS 1031

  Fly  1450 LVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVW 1514
            ||||.||||.:.:....:|..::|:.:....:||.|::..:.||:|.|||||.:|||.||||:..
Human  1032 LVLFFIPYGAFYNVAGEDGQHIADYQSFAVTMATSLVIVVSVQIALDTSYWTFINHVFIWGSIAI 1096

  Fly  1515 YF-VLDYFYNYVIGG------PYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSL 1572
            || :|...::..|.|      |:||:...::.....|:.:|:|.:|.|.||:|::|..:|::|:|
Human  1097 YFSILFTMHSNGIFGIFPNQFPFVGNARHSLTQKCIWLVILLTTVASVMPVVAFRFLKVDLYPTL 1161

  Fly  1573 SDKIR--QKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQEGFGRLITSGKIMH-KLPQDF 1634
            ||:||  ||:.||....:|...|...||.|     |||||||||||:|.||||||.|. |.|   
Human  1162 SDQIRRWQKAQKKARPPSSRRPRTRRSSSR-----RSGYAFAHQEGYGELITSGKNMRAKNP--- 1218

  Fly  1635 AFPLGLGTKKTQVLHNNLNS 1654
              |...|.:||   |.|..|
Human  1219 --PPTSGLEKT---HYNSTS 1233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8BNP_731669.2 PhoLip_ATPase_N 195..260 CDD:292826 42/64 (66%)
Cation_ATPase 891..985 CDD:289987 57/95 (60%)
HAD_like <1261..1324 CDD:304363 52/62 (84%)
PhoLip_ATPase_C 1324..1571 CDD:292829 134/253 (53%)
ATP8B4XP_011520348.1 PhoLip_ATPase_N 51..116 CDD:292826 42/64 (66%)
ATPase-Plipid 65..1167 CDD:273734 612/1416 (43%)
Cation_ATPase 538..634 CDD:289987 57/95 (60%)
HAD_like <875..906 CDD:304363 29/30 (97%)
PhoLip_ATPase_C 906..1160 CDD:292829 134/253 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 478 1.000 Domainoid score I424
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1308 1.000 Inparanoid score I152
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D39163at33208
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 1 1.100 - - O PTHR24092
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X168
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.840

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