Protein Alignment ATP8B and ATP8B4

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_011520348.1
• Gene: ATP8B4 / 79895
• HGNCID: 13536
• Length: 1257
• Species: Homo sapiens
• Alignment Length: 1515
• Identity: 659/1515 - (43%)
• Similarity: 860/1515 - (56%)
• Gaps: 379/1515 - (25%)

  Fly   191 ENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISS 255
            |.||.::|||:|:|.:|:|.:|.|.||||::.||||.||.|||||:||.||||||:|||||.|||
Human    47 EVERIVKANDREYNEKFQYADNRIHTSKYNILTFLPINLFEQFQRVANAYFLCLLILQLIPEISS 111

  Fly   256 LTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLD 320
            ||..||.:||:.|:|:||||||.||..||.||:|||||:|:.|.|.||...||..|:|||:|:|:
Human   112 LTWFTTIVPLVLVITMTAVKDATDDYFRHKSDNQVNNRQSEVLINSKLQNEKWMNVKVGDIIKLE 176

  Fly   321 NNQFVAADTLLLSTSEPNGLCFIETAELDG----------------------------ETNLKAK 357
            ||||||||.||||:|||:|||::|||||||                            |||||.:
Human   177 NNQFVAADLLLLSSSEPHGLCYVETAELDGSLCCYKDVPWVECQLFGAQEALPTFLKQETNLKVR 241

  Fly   358 QCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQW 422
            ..|:.|.|||.....|..|:|.::||.|||.|:||.|.|.|:..:.:|:||||:||||:||||.|
Human   242 HALSVTSELGADISRLAGFDGIVVCEVPNNKLDKFMGILSWKDSKHSLNNEKIILRGCILRNTSW 306

  Fly   423 CYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHF 487
            |:|:|:|||.|||||||||||:||.|.:|||:|.:::.|..||:.:..:.|||.:|||...|..|
Human   307 CFGMVIFAGPDTKLMQNSGKTKFKRTSIDRLMNTLVLWIFGFLICLGIILAIGNSIWESQTGDQF 371

  Fly   488 QLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYY 552
            :.:|.|..      ....:...|.|.|:||.|:|||||||||||||||||...|:.||||.:|||
Human   372 RTFLFWNE------GEKSSVFSGFLTFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDRKMYY 430

  Fly   553 PTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITE 617
            ......|.|||||||||||||:|||||||||||||||||.:||||||.||:|.|
Human   431 SRKAIPAVARTTTLNEELGQIEYIFSDKTGTLTQNIMTFKRCSINGRIYGEVHD----------- 484

  Fly   618 QQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDI 682
                                                                             
Human   485 ----------------------------------------------------------------- 484

  Fly   683 ERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGA 747
                                        |.|
Human   485 ----------------------------DLD---------------------------------- 487

  Fly   748 GCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHL 812
                                  |:||                               |:|
Human   488 ----------------------QKTE-------------------------------ITQ----- 494

  Fly   813 DEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRS 877
            ::||                                   ||||.....:.:|:::|..|:::::.
Human   495 EKEP-----------------------------------VDFSVKSQADREFQFFDHHLMESIKM 524

  Fly   878 DEEHSHVFFRLLALCHTVMA-ETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMG 941
            .:...|.|.||||||||||: |...|:|.||.|||||.|||:|||||||:|::|||.:||||.:|
Human   525 GDPKVHEFLRLLALCHTVMSEENSAGELIYQVQSPDEGALVTAARNFGFIFKSRTPETITIEELG 589

  Fly   942 QTEEYELLNILDFNNVRKRMSVILRRGDSMV-LYCKGADNVIYDRLHGGQEDLKARTQDHLNKFA 1005
            ....|:||..|||||.|||||||:|..:..: ||.||||.:::::||...|.|.:.|.|||::||
Human   590 TLVTYQLLAFLDFNNTRKRMSVIVRNPEGQIKLYSKGADTILFEKLHPSNEVLLSLTSDHLSEFA 654

  Fly  1006 GEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQD 1070
            ||||||||:|.|.|.::|:.:|....::|..:.:.|::::..:|||||.::.|:|.||:|||||:
Human   655 GEGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEERDERIAGLYEEIERDLMLLGATAVEDKLQE 719

  Fly  1071 GVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKES 1135
            ||.:::.:|..|.|||||||||||||||||||:|.:|||::.|||::.||:..||.::||:.|:
Human   720 GVIETVTSLSLANIKIWVLTGDKQETAINIGYACNMLTDDMNDVFVIAGNNAVEVREELRKAKQ- 783

  Fly  1136 IKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNK 1200
                                                                             
Human   784 ----------------------------------------------------------------- 783

  Fly  1201 DNKGGPDSAECNNLFGDEKGSEDGGTA----------SIVVDENTG-FALVVNGHSLVHCLSPEL 1254
                        ||||..:...:|...          |||.:..|| :||::|||||.|.|..::
Human   784 ------------NLFGQNRNFSNGHVVCEKKQQLELDSIVEETITGDYALIINGHSLAHALESDV 836

  Fly  1255 ENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQE 1319
            :|..|::|..||.||||||||||||.||||:|:.:||||||||||||||||||:|||||||||||
Human   837 KNDLLELACMCKTVICCRVTPLQKAQVVELVKKYRNAVTLAIGDGANDVSMIKSAHIGVGISGQE 901

  Fly  1320 GLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTV 1384
            ||||||:||||.||||||:|||||||||||:||||||.|||||||||||.|.|:..|||||||||
Human   902 GLQAVLASDYSFAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTV 966

  Fly  1385 FDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTS 1449
            :|..||:::|:.||||||||:|:|:|||||:||::.|:||.||..:.|||.|:|...||||.:||
Human   967 YDQWFITLFNIVYTSLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYTS 1031

  Fly  1450 LVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVW 1514
            ||||.||||.:.:....:|..::|:.:....:||.|::..:.||:|.|||||.:|||.||||:..
Human  1032 LVLFFIPYGAFYNVAGEDGQHIADYQSFAVTMATSLVIVVSVQIALDTSYWTFINHVFIWGSIAI 1096

  Fly  1515 YF-VLDYFYNYVIGG------PYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSL 1572
            || :|...::..|.|      |:||:...::.....|:.:|:|.:|.|.||:|::|..:|::|:|
Human  1097 YFSILFTMHSNGIFGIFPNQFPFVGNARHSLTQKCIWLVILLTTVASVMPVVAFRFLKVDLYPTL 1161

  Fly  1573 SDKIR--QKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQEGFGRLITSGKIMH-KLPQDF 1634
            ||:||  ||:.||....:|...|...||.|     |||||||||||:|.||||||.|. |.|
Human  1162 SDQIRRWQKAQKKARPPSSRRPRTRRSSSR-----RSGYAFAHQEGYGELITSGKNMRAKNP--- 1218

  Fly  1635 AFPLGLGTKKTQVLHNNLNS 1654
              |...|.:||   |.|..|
Human  1219 --PPTSGLEKT---HYNSTS 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	239/418 (57%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	304/583 (52%)
ATP8B4	XP_011520348.1	P-type_ATPase_APLT_Dnf-like	67..1038	CDD:319770	564/1285 (44%)