DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ATP8B and Atp11b

DIOPT Version :9

Sequence 1:NP_731669.2 Gene:ATP8B / 41469 FlyBaseID:FBgn0037989 Length:1726 Species:Drosophila melanogaster
Sequence 2:NP_083846.2 Gene:Atp11b / 76295 MGIID:1923545 Length:1175 Species:Mus musculus


Alignment Length:1480 Identity:428/1480 - (28%)
Similarity:676/1480 - (45%) Gaps:415/1480 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   144 GNPPPNKSDDQELYKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQFK 208
            |..||::||.:.:|                      |..|     |.:|..        :..| |
Mouse    10 GFDPPHQSDTRTIY----------------------IANR-----FPQNGL--------YTPQ-K 38

  Fly   209 YHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLT-PVTTAIPLIGVLTLT 272
            :.:|.|.:|||:::.|:|.||.|||:|:||||||.:.::||:  |.:.| |:|:.:||..|:|:|
Mouse    39 FIDNRIISSKYTIWNFVPKNLFEQFRRVANFYFLIIFLVQLM--IDTPTSPITSGLPLFFVITVT 101

  Fly   273 AVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEP 337
            |:|..|:|..||.||::||......:|:|.||:.:...::|||::|:..::...||.:|||:...
Mouse   102 AIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRL 166

  Fly   338 NGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEII---CERPNNLLNKFDGTLIWR 399
            :|.|.:.||.||||||||....:.||..|    .::.|.:..|.   |::|...|.:|.|.:|..
Mouse   167 DGSCHVTTASLDGETNLKTHVSVPETAVL----QTVANLDSLIAVIECQQPEADLYRFMGRMIIT 227

  Fly   400 GQR----FALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIG 460
            .|.    ..|..|.:||||..|:||:..:||.|:.|::||:..|......|.:.|::.:|..:|.
Mouse   228 QQMEEIVRPLGPESLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLII 292

  Fly   461 IVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVV 525
            .::.|:|...:..|....|:.    ..:...||.:...:....:...:..:..|.::.::.|.::
Mouse   293 YLIILISEAIISTILKYTWQA----EEKWDEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFII 353

  Fly   526 PISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMT 590
            ||||||:||:.:|:.||.|.||.::|:..::..|:..|:.|||||||::|:|:|||||||:|.|.
Mouse   354 PISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQ 418

  Fly   591 FNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAE 655
            |.:|||||..|.::    .|:||                            |..|.|        
Mouse   419 FRECSINGLKYQEI----NGKLV----------------------------PEGPSP-------- 443

  Fly   656 VHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPR 720
                       .|.|.:|              |...|     |.|:..||               
Mouse   444 -----------DSTEGEV--------------PFLGS-----LSHLSNSA--------------- 463

  Fly   721 LDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRK 785
                                            .|:.||       |..|.::||           
Mouse   464 --------------------------------HLTATS-------LRTSPESET----------- 478

  Fly   786 RLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQ 850
            .|:|                   ||.|                                      
Mouse   479 ELIK-------------------EHDL-------------------------------------- 486

  Fly   851 SVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETV------DG------- 902
                                              ||:.::|||||....|      ||       
Mouse   487 ----------------------------------FFKAVSLCHTVQISNVQTDGIGDGPWQPNLA 517

  Fly   903 --KLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVIL 965
              :|||.|.||||.|||.||...|.:|...:..::.::|:|:.|.|:||:||:|::.|:|||||:
Mouse   518 PAQLEYYASSPDEKALVEAAARAGIIFVGISEETMEVKVLGRLERYKLLHILEFDSDRRRMSVIV 582

  Fly   966 R--RGDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWR 1028
            :  .|:.: |:.|||::.|..:..||:   .|:|:.|:::||.:|||||.:|.|:.|.:.|.|..
Mouse   583 QAPSGEKL-LFAKGAESSILPKCIGGE---IAKTRIHVDEFALKGLRTLCIAYRQFTAKEYEDVD 643

  Fly  1029 SRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDK 1093
            .|..||..::..||:||...::.||.::.|:|.||:||:|||.|.::|..|:.||||:|||||||
Mouse   644 RRLFEARTALQHREEKLADAFQYIEKDLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDK 708

  Fly  1094 QETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSN 1158
            .|||:::..||......:..:.:::..|.....:||||....|                      
Mouse   709 HETAVSVSLSCGHFHRTMNILELINQKSDSGCAEQLRQLARRI---------------------- 751

  Fly  1159 MDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSED 1223
                                                                             
Mouse   752 ----------------------------------------------------------------- 751

  Fly  1224 GGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIK-R 1287
              |...|:..    .|||:|.||...|. |.|..|:::...|.||:|||:.|||||.|:.||| .
Mouse   752 --TEDHVIQH----GLVVDGTSLSLALR-EHEKLFMEVCRNCSAVLCCRMAPLQKAKVIRLIKIS 809

  Fly  1288 AKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRM 1352
            .:..:|||:||||||||||:.||:|:||.|:||.||..:|||:||:|::|.:||.|||.:.|.|:
Mouse   810 PEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAIARFKFLSKLLFVHGHFYYIRI 874

  Fly  1353 CKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNS 1417
            ...::||||||..|......|..:|.||.||::|.:::::||:.:||||||...:.||.:.....
Mouse   875 ATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTSLPVLIYSLVEQHIDPHVL 939

  Fly  1418 LEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVY----KD-GVSANGFVVSDHMTL 1477
            ...|.||....|:.|.:|:.|:|..:.|...:.:.|   :|.|    || .:..||.:.. :.|.
Mouse   940 QSKPTLYRDISKNGLLSIKAFLYWTVLGFSHAFIFF---FGSYFLVGKDTSLLGNGQMFG-NWTF 1000

  Fly  1478 GAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGS------LTQ 1536
            |.:|.|::::..|.:::|.|.:||.:||:..|||:::||:...||..:: .|::||      ..|
Mouse  1001 GTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFIFSLFYGGIL-WPFLGSQNMYFVFIQ 1064

  Fly  1537 AMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHS 1586
            .:...:.|..:|:.|:..:...:..|.:...:||:.::|.:   |.:.||
Mouse  1065 LLSSGSAWFAILLMVVTCLFIDVVKKVFDRQLHPTSTEKAQ---LAEAHS 1111

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8BNP_731669.2 PhoLip_ATPase_N 195..260 CDD:292826 26/65 (40%)
Cation_ATPase 891..985 CDD:289987 44/110 (40%)
HAD_like <1261..1324 CDD:304363 37/63 (59%)
PhoLip_ATPase_C 1324..1571 CDD:292829 81/257 (32%)
Atp11bNP_083846.2 PhoLip_ATPase_N 21..89 CDD:292826 31/105 (30%)
ATPase-Plipid 39..1105 CDD:273734 413/1404 (29%)
E1-E2_ATPase 96..>180 CDD:278548 32/83 (39%)
Cation_ATPase 493..604 CDD:289987 44/111 (40%)
HAD_like 628..867 CDD:304363 108/332 (33%)
PhoLip_ATPase_C 846..1099 CDD:292829 81/257 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.720

Return to query results.
Submit another query.