Protein Alignment ATP8B and Atp8b5p

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_038966915.1
• Gene: Atp8b5p / 691125
• RGDID: 1587460
• Length: 1191
• Species: Rattus norvegicus
• Alignment Length: 1483
• Identity: 614/1483 - (41%)
• Similarity: 805/1483 - (54%)
• Gaps: 359/1483 - (24%)

  Fly   185 SSYYFSENERR--------IRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYF 241
            |:.|..|||:|        ::||::.||:.|:|.:|.|||||||.|.|||.||.||||||||.||
  Rat    20 SAMYERENEQRQNEEEERILQANNRRFNSLFEYPDNSIKTSKYSFFNFLPVNLFEQFQRLANAYF 84

  Fly   242 LCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDI------------QRHISDSQVNNRK 294
            |.||.|||||.||||...||.||||.||::|.||||.||:            :||.||.|||||.
  Rat    85 LILLFLQLIPQISSLAWYTTVIPLIVVLSITGVKDAIDDVVKWLPGLPSLHLKRHQSDQQVNNRS 149

  Fly   295 SKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQC 359
            ...|.||::.|.||..|||||:|:|:|:..|.||.||||:|||.||.:||||:||||||||.||.
  Rat   150 VLILVNGRIEENKWRNVQVGDIIKLENDHPVTADVLLLSSSEPYGLTYIETADLDGETNLKVKQA 214

  Fly   360 LTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCY 424
            ::.|.::.|..:.|..||||:.||.|||.|::|.|||.:.|..:.||.|::|||||::|||.|||
  Rat   215 VSATSDMEDNLELLSAFNGEVRCEPPNNKLDRFSGTLSYLGDTYFLDYERLLLRGCIIRNTDWCY 279

  Fly   425 GVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQL 489
            |:||:.|.|||||||||::.||.|.:|.|:|.:::.|.:.|..:|.|.:||..|||...|.|||.
  Rat   280 GLVVYTGPDTKLMQNSGRSTFKRTHIDHLMNVLVLWIFMLLGGMCFLLSIGHGIWESNRGYHFQA 344

  Fly   490 YLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPT 554
            :||||..|      |.:.....|.|:||.|||||:||||||||||:||...|:.||||.:|:|..
  Rat   345 FLPWERYI------TSSAASSALAFWSYFIVLNTMVPISLYVSVEIIRLGNSYYINWDRKMFYAP 403

  Fly   555 TNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQ 619
            .||.|:||||||||||||::|:|||||||||:|:|.||||||||::||
  Rat   404 KNTPAQARTTTLNEELGQVEYVFSDKTGTLTENVMIFNKCSINGKTYG----------------- 451

  Fly   620 TIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIER 684
                                                                             
  Rat   452 ----------------------------------------------------------------- 451

  Fly   685 SAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGC 749
                              ||                .|.:|...|
  Rat   452 ------------------YS----------------YDENGQCVP-------------------- 462

  Fly   750 MQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDE 814
                                                        |:||
  Rat   463 --------------------------------------------KSPS----------------- 466

  Fly   815 EPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDE 879
                                               ..||||.|...:..|.:||:||::||:|::
  Rat   467 -----------------------------------NKVDFSYNHLADPKFSFYDKTLVEAVKSED 496

  Fly   880 EHSHVFFRLLALCHTVMA-ETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQT 943
            ...::||..|:||||||: |.|:|:|.||||||||.|||:|:|||||||.:|||.:||:..||:.
  Rat   497 PLVYLFFLCLSLCHTVMSEEKVEGELVYQAQSPDEGALVTASRNFGFVFHSRTPETITVIEMGRV 561

  Fly   944 EEYELLNILDFNNVRKRMSVILRR-GDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGE 1007
            ..|.||.||||:|.|||||||::. .|.::|:|||||.:||:.||.....|...|.|.|:.||.|
  Rat   562 RVYRLLAILDFSNERKRMSVIVQTPEDRVMLFCKGADTIIYELLHPSCAALSDVTMDQLDDFASE 626

  Fly  1008 GLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGV 1072
            |||||.:|.|.|.:.::..|..:..||.|::::||:||..:|||||.::.|:|.||||||||.||
  Rat   627 GLRTLMVAYRELDKAFFQTWIKKHGEAWLTLENREKKLALVYEEIERDLVLLGATAIEDKLQSGV 691

  Fly  1073 PKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIK 1137
            |::|..|..|.||||||||||||||:||.|||::..||:..||:|:|...|.|.::||..::.:|
  Rat   692 PETIVTLNKAKIKIWVLTGDKQETAVNIAYSCRIFKDEMDAVFMVEGTDRETVLEELRTARKKMK 756

  Fly  1138 IYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDN 1202
                       |...|.|    ||:::.:.:.|      .:|             |:
  Rat   757 -----------PESLLES----DPINIYLARKS------KMP-------------FK-------- 779

  Fly  1203 KGGPDSAECNNLFGDEKGSEDGGTASIVVDE--NTGFALVVNGHSLVHCLSPELENKFLDIASQC 1265
                                       .|||  |..:.||::|.||.:.|....|.:.|..|..|
  Rat   780 ---------------------------AVDEVPNGSYGLVISGCSLAYALESNTEFELLRTACMC 817

  Fly  1266 KAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYS 1330
            |.|:|||:||||||.||:|:||.|..|||||||||||:.||||||||||||||||:||.||||:|
  Rat   818 KGVVCCRMTPLQKAQVVDLVKRYKKVVTLAIGDGANDIGMIKAAHIGVGISGQEGMQATLSSDFS 882

  Fly  1331 IAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNL 1395
            ..|||||:|||||||||||.||||||.|||||||||||.|.||:.|.|||||||:|..||:.|||
  Rat   883 FCQFRYLQRLLLVHGRWSYNRMCKFLSYFFYKNFAFTLVHFWYAFFNGFSAQTVYDIWFITFYNL 947

  Fly  1396 FYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVY 1460
            .|||||:|.|.:||:||::..||.:|.||.||..:..||.:|||..:|||.::|.|||.:|.|..
  Rat   948 IYTSLPILGLSLFEKDVNETWSLCYPELYEPGQHNLYFNKKEFIKCLLHGIYSSFVLFFVPMGTV 1012

  Fly  1461 KDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYF---- 1521
            .:...::|..:||..:...:|.|.||...|.||:|.|:|||::||...||||..||.:.:.
  Rat  1013 FNSERSDGKDISDFQSFSLLVQTTLIWVMTMQIALSTTYWTMINHAFTWGSLGLYFCILFLLCSD 1077

  Fly  1522 ---------YNYVIGGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIR 1577
                     :|      ::|.....:.....|:.::::.:..:.|::.|.|....:.|...||:
  Rat  1078 GLCLMFPSVFN------FLGVARNGLNQPQMWLCLVLSSVLCLIPLMGYNFLKPILWPINVDKV- 1135

  Fly  1578 QKSLKKIHSRASSDVR---RTASSRRGRRSVRSGYAFAHQEGFGRLITSGKIM 1627
               |.:||......:.   :......|.|  ||.|||:|::|||.||||||.:
  Rat  1136 ---LNRIHFCLKHPLPPPVQIKVKHPGLR--RSAYAFSHKQGFGALITSGKTL 1183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	43/72 (60%)
		Cation_ATPase	891..985	CDD:289987	60/95 (63%)
		HAD_like	<1261..1324	CDD:304363	47/62 (76%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	116/259 (45%)
Atp8b5p	XP_038966915.1	P-type_ATPase_APLT_Dnf-like	54..1008	CDD:319770	548/1260 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	441	1.000	Domainoid score	I525
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1303	1.000	Inparanoid score	I143
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D39163at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.980