Protein Alignment ATP8B and Atp8b2

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_001062555.3
• Gene: Atp8b2 / 685152
• RGDID: 1597731
• Length: 1209
• Species: Rattus norvegicus
• Alignment Length: 1454
• Identity: 662/1454 - (45%)
• Similarity: 854/1454 - (58%)
• Gaps: 332/1454 - (22%)

  Fly   190 SENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAIS 254
            :|.|||.||||:|:|.:|:|.:|.||||||::.||||.||.||||.:||.|||.||:|||||.||
  Rat    29 TEEERRARANDREYNEKFQYASNCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQIS 93

  Fly   255 SLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRL 319
            ||:..||.:||:.|||:||||||.||..||.||:|||:|.|:.|.||.|.:.:|..|.|||:|:|
  Rat    94 SLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQVNSRHSQVLINGVLQQEQWMNVCVGDIIKL 158

  Fly   320 DNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICER 384
            :||||||||.||||:|||:|||:|||:|||||||:|.:|.:..|.|||| ...|..|:||:|||.
  Rat   159 ENNQFVAADLLLLSSSEPHGLCYIETSELDGETNMKVRQAIPVTSELGD-ISQLAKFDGEVICEP 222

  Fly   385 PNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTG 449
            |||.|:||.|.|.|:|.:|.|.|:.:||||||||||:||:|:|:|||.|||||||||:|:||.|.
  Rat   223 PNNKLDKFSGALYWKGNKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTS 287

  Fly   450 VDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVF 514
            :|||:|.:::.|..|||.:..:.|||.||||..:|..||:||||:..:...:..      |.|.|
  Rat   288 IDRLMNTLVLWIFGFLVCMGVILAIGNAIWEHEVGTRFQVYLPWDEAVDSAFFS------GFLSF 346

  Fly   515 FSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSD 579
            :||.|:|||||||||||||||||...|:.||||::|:.....|.|:||||||||||||::|||||
  Rat   347 WSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCMKKRTPAEARTTTLNEELGQVEYIFSD 411

  Fly   580 KTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAA 644
            ||||||||||.||||||||.|||||.|
  Rat   412 KTGTLTQNIMVFNKCSINGHSYGDVFD-------------------------------------- 438

  Fly   645 PPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRS 709
                :|.||||                  |.:||
  Rat   439 ----VLGHKAE------------------LGERP------------------------------- 450

  Fly   710 QDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTET 774
                                                                             
  Rat   451 ----------------------------------------------------------------- 450

  Fly   775 HNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNW 839
                                                    ||
  Rat   451 ----------------------------------------EP----------------------- 452

  Fly   840 SSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETV-DGK 903
                        ||||.||..:..|.::|.:||:||:..:.|:|.|||||:||||||:|.. :|:
  Rat   453 ------------VDFSFNPLADKKFLFWDPSLLEAVKMGDPHTHEFFRLLSLCHTVMSEEKNEGE 505

  Fly   904 LEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRG 968
            |.|:||||||.|||:||||||||||:|||.::|:..:|.:..|:||.||||||:|||||||:|..
  Rat   506 LYYKAQSPDEGALVTAARNFGFVFRSRTPKTVTVHELGTSITYQLLAILDFNNIRKRMSVIVRNP 570

  Fly   969 DSMV-LYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQ 1032
            :..: |||||||.::.||||...::|...|.||||::||:|||||.||.:.|.|:||.:|..|:.
  Rat   571 EGKIRLYCKGADTILLDRLHPSTQELLNSTTDHLNEYAGDGLRTLVLAYKDLDEEYYEEWARRRL 635

  Fly  1033 EAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETA 1097
            :|:|:.||||.:|.:||||:||:|.|:|.||||||||.|||::||.|..|.||||||||||||||
  Rat   636 QASLAQDSREDRLASIYEEVESDMMLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETA 700

  Fly  1098 INIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPL 1162
            :||||||::|||::.:||||.|::|.||.::||:.::.:             .|..::..|
  Rat   701 VNIGYSCKMLTDDMTEVFIVTGHTVLEVREELRKARKKM-------------VDSSHAVGN---- 748

  Fly  1163 SVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTA 1227
                    .|..:.||                            .|::..::.....|.
  Rat   749 --------GFTYQGNL----------------------------SSSKLTSVLEAVAGE------ 771

  Fly  1228 SIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAV 1292
                     :|||:|||||.|.|..::|.:||:.|..|||||||||||||||.||||:|:.|.||
  Rat   772 ---------YALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAV 827

  Fly  1293 TLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLR 1357
            |||||||||||||||.||||||||||||:||||:||||.:||::|:|||||||||||.||||||.
  Rat   828 TLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLC 892

  Fly  1358 YFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPR 1422
            ||||||||||:.|.|:..|||||||||:|..||::||:.||||||||:|||:|||.::.|:|:|:
  Rat   893 YFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPK 957

  Fly  1423 LYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIV 1487
            ||.||..:.|||.|||...:..|.:||:::|.|||||:.:....:|..::|:.:....|||.|::
  Rat   958 LYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVFAEATRDDGTQLADYQSFAVTVATSLVI 1022

  Fly  1488 DNTAQISLYTSYWTVVNHVTIWGSLVWYFVL----------DYFYNYVIGGPYVGSLTQAMKDLT 1542
            ..:.||.|.|.|||.:||..|||||..||.:          |.|.|..   .:||:....:...|
  Rat  1023 VVSVQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQF---RFVGNAQNTLAQPT 1084

  Fly  1543 FWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSL----KKIHSRASSDVRRTASSRRGRR 1603
            .|:|:::|....:.||:|::|..|.:.|.|||.:|...|    :|...|....|.||.|.
  Rat  1085 VWLTIVLTTAVCIMPVVAFRFLRLSLKPDLSDTVRYTQLVRKKQKAQHRCMRRVGRTGSR----- 1144

  Fly  1604 SVRSGYAFAHQEGFGRLITSGKIM 1627
              ||||||:||||||.||.|||.|
  Rat  1145 --RSGYAFSHQEGFGELIMSGKNM 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	242/390 (62%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	308/572 (54%)
Atp8b2	XP_001062555.3	P-type_ATPase_APLT_Dnf-like	50..991	CDD:319770	579/1246 (46%)
		Cation_ATPase_C	929..1104	CDD:376368	71/177 (40%)