DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8B and Atp8b3

DIOPT Version :9

Sequence 1:NP_731669.2 Gene:ATP8B / 41469 FlyBaseID:FBgn0037989 Length:1726 Species:Drosophila melanogaster
Sequence 2:NP_080370.2 Gene:Atp8b3 / 67331 MGIID:1914581 Length:1335 Species:Mus musculus


Alignment Length:1491 Identity:501/1491 - (33%)
Similarity:739/1491 - (49%) Gaps:380/1491 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   196 IRANDKEFNAQF-----------KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQL 249
            ::|||:.::.||           ||.:|.|.|:||::|:|||.||.|||.|::|.|||.:::||.
Mouse    21 VKANDRTYHKQFKKKGFLCWRQKKYKSNAIHTAKYNIFSFLPLNLYEQFHRMSNLYFLFIIILQG 85

  Fly   250 IPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVG 314
            ||.||:|...|...||:.:..:.|.:|..|||.||.||..:|||..:.||....:..||..:.||
Mouse    86 IPEISTLPWFTLFAPLVCLFVIRATRDLVDDIGRHRSDKIINNRPCQILRGKSFLWKKWKNLCVG 150

  Fly   315 DVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHD-----SLW 374
            ||:.|..:..|.||.|||:::||:.||::|||::|||||||.:|.||.|     .|:     .:.
Mouse   151 DVVCLSKDSIVPADLLLLASTEPSSLCYVETADIDGETNLKFRQALTVT-----HHELTSPKKMA 210

  Fly   375 NFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQN 439
            :|.|.:.||.||:.::.|.|:|.|..:::.||...:|||||.:|||..|||:|::||:|||:|:|
Mouse   211 SFQGTVTCEEPNSRMHHFVGSLEWNSRKYPLDIGNLLLRGCKIRNTDTCYGLVIYAGLDTKIMKN 275

  Fly   440 SGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIW-EGLIGQHFQLYLPWEHIIPKDYIP 503
            .||...|.|.:|.::|.::..|.|.||....|..:|.... :....:|:  |:...|       .
Mouse   276 CGKIHLKRTKLDLMMNKLVALIFLSLVIASLLLTVGFTFMVKQFKAKHY--YMSPTH-------G 331

  Fly   504 TGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNE 568
            ....:....:|:.:.|:|:.:||:::::..|.|....|..||||..|||...:..||||:|:||:
Mouse   332 RSDAMESFFIFWGFLILLSVMVPMAMFIIAEFIYLGNSIFINWDLNMYYEPLDMPAKARSTSLND 396

  Fly   569 ELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSP 633
            :|||:||||||||||||||||||.||.|||..|                                
Mouse   397 QLGQVQYIFSDKTGTLTQNIMTFKKCCINGCIY-------------------------------- 429

  Fly   634 LSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGL 698
                                                                             
Mouse   430 ----------------------------------------------------------------- 429

  Fly   699 KHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKV 763
                        |:|        |..|.|                                    
Mouse   430 ------------DSD--------DEHGTL------------------------------------ 438

  Fly   764 KILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHH 828
                                |||                                          
Mouse   439 --------------------RKR------------------------------------------ 441

  Fly   829 HHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHS-HVFFRLLALC 892
                         :|          ::.||..:...::|::.|...|:..::.: ..|:||||:|
Mouse   442 -------------NP----------YAWNPFADGKLQFYNKELESLVQGRQDRAVQEFWRLLAIC 483

  Fly   893 HTVMAETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNV 957
            ||||.:..|.:|.|||.||||.|||:||||||:||.:||.::||:..:|:...|::|.::|||:|
Mouse   484 HTVMVQEKDNQLLYQAASPDEEALVTAARNFGYVFLSRTQDTITLVELGEERVYQVLAMMDFNSV 548

  Fly   958 RKRMSVILRRGD-SMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTE 1021
            ||||||::|..: |:.||.||||.||.:||. .:..::|.|::.|..||.:.||||.||.:.:.|
Mouse   549 RKRMSVLVRNPEGSICLYTKGADTVILERLR-SKGVMEATTEEVLAAFAEQTLRTLCLAYKDVEE 612

  Fly  1022 QYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKI 1086
            ..|.:|....|||||.:.:|.|.|:.:|.::|..:||:|.||||||||||||::|..|:...|||
Mouse   613 DAYKEWEPEHQEAALLLQNRAQALHQVYNKMEQNLQLLGATAIEDKLQDGVPETIKCLKKGNIKI 677

  Fly  1087 WVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFD 1151
            |||||||.|||:|||::||||::   ::.|::...:.:|   |.::.|.......|:........
Mouse   678 WVLTGDKPETAVNIGFACQLLSE---NMIILEDKDINQV---LERYWEDNVHQKAFKMMTHHNMA 736

  Fly  1152 RLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTF--------RWDEKNKDNKGGPDS 1208
            .:.:...:|.|.:::.:....:.:..:.......|.:|.:.|        .|      ...||..
Mouse   737 LVINGEFLDQLLLSLRKEPRALVQNAVVDEVAQEPVVSALDFLQKRRISQMW------RNAGPSL 795

  Fly  1209 AECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPEL--ENKFLDIASQCKAVICC 1271
            ...::  .|.|..|                            |||:  |..|:|:||:|:|||||
Mouse   796 GTSHS--ADSKIRE----------------------------SPEVQRERAFVDLASKCQAVICC 830

  Fly  1272 RVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRY 1336
            ||||.||||||.|:|:.:..||||||||||||:|||.|.||||::||||:|||.:|||.:|||.|
Mouse   831 RVTPKQKALVVALVKKYQQVVTLAIGDGANDVNMIKTADIGVGLAGQEGMQAVQNSDYVLAQFCY 895

  Fly  1337 LERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLP 1401
            |:|||||||||||.|:||||||||||..|..:...|:||..|||||.:::..|::::||.|::||
Mouse   896 LQRLLLVHGRWSYMRVCKFLRYFFYKTVASMMAQIWFSLVNGFSAQPLYEGWFLALFNLLYSTLP 960

  Fly  1402 VLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSA 1466
            ||.:|:|||||:.:.||:.|.||..|.|.||||...|:.::.||..||::.|.:...|..|...|
Mouse   961 VLYIGLFEQDVTAEKSLKMPELYMAGQKGELFNYSIFMQAITHGTITSMINFFVTVMVSSDMSKA 1025

  Fly  1467 NGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYV 1531
            ..  ..|:.:||.:||...::..|.::.|...|||::        .|...||. ..:||:    :
Mouse  1026 GS--SHDYQSLGVLVAISSLLSVTLEVMLVVKYWTLL--------FVGAVVLS-LSSYVL----M 1075

  Fly  1532 GSLTQAMKDLTFWV----------------------TMLITVMAL---VAPVLAYKFYLLDVHPS 1571
            .||||::     |:                      ::|:.|:.:   |.|:||    |..:|.:
Mouse  1076 TSLTQSL-----WMYRISPKTFPFLFADYNVLFEPCSLLLIVLNVALNVLPMLA----LRTIHRT 1131

  Fly  1572 LSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSV---RSGYAFAHQEGFGRLITSGKIMHK 1629
            :   ::|:. |......|.:|....:.|..||.:   ||.|||:|:||:..|||.|.|:.:
Mouse  1132 V---LKQRP-KGEEEAPSEEVAVEPAMRHLRRGIPARRSSYAFSHREGYANLITQGTILRR 1188

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8BNP_731669.2 PhoLip_ATPase_N 195..260 CDD:292826 33/74 (45%)
Cation_ATPase 891..985 CDD:289987 52/94 (55%)
HAD_like <1261..1324 CDD:304363 45/62 (73%)
PhoLip_ATPase_C 1324..1571 CDD:292829 102/271 (38%)
Atp8b3NP_080370.2 PhoLip_ATPase_N 20..96 CDD:292826 33/74 (45%)
ATPase-Plipid 45..1131 CDD:273734 475/1404 (34%)
Cation_ATPase 483..580 CDD:289987 54/97 (56%)
COG4087 <839..890 CDD:226572 35/50 (70%)
PhoLip_ATPase_C 883..1131 CDD:292829 102/271 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1192..1215
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1236..1280
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1314..1335
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 121 1.000 Domainoid score I5669
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 1 1.100 - - O PTHR24092
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.830

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