Protein Alignment ATP8B and atp8b1

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_001025562.1
• Gene: atp8b1 / 594952
• XenbaseID: XB-GENE-490143
• Length: 1250
• Species: Xenopus tropicalis
• Alignment Length: 1517
• Identity: 604/1517 - (39%)
• Similarity: 811/1517 - (53%)
• Gaps: 351/1517 - (23%)

  Fly   151 SDDQELYKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQ--------- 206
            |||     :.|..:.|.....|...|.:....:.......|...:::|||:.|..|
 Frog    24 SDD-----ETDDELDSPQTDEPEQNRRNVQAEQSREPVIKECTWQVKANDRNFYDQPEFKKKVFL 83

  Fly   207 ----FKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIG 267
                .||..|.|||.||:..||||.||.|||:|.||.|||.||:||.||.||::|..||.|||:.
 Frog    84 CLKKSKYAGNAIKTYKYNPITFLPVNLYEQFKRAANAYFLVLLILQTIPQISTVTWSTTLIPLLL 148

  Fly   268 VLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLL 332
            ||.:||:||..|||.||..|:::|||.|:.:.:|:..:.||..:.|||:||::.|:||.||.|||
 Frog   149 VLGITAIKDLVDDIARHKMDNEINNRPSEVITDGRFKKTKWKHIHVGDIIRINKNEFVPADVLLL 213

  Fly   333 STSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLI 397
            |:|:||.||::||||||||||||.|..|..|.:|..:.:.|..|:|.:.||.|||.|:||.|||.
 Frog   214 SSSDPNSLCYVETAELDGETNLKFKMSLEITDKLLQKEEQLAGFDGLVECEEPNNRLDKFVGTLF 278

  Fly   398 WRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIV 462
            |||..|.||.:|||||||.:|||::|:|:|:|||.|||:|:|||||:.|.|.:|.|:|:::..|.
 Frog   279 WRGNSFGLDADKILLRGCTVRNTEYCHGLVLFAGADTKIMRNSGKTRLKRTKIDYLMNYMVYTIF 343

  Fly   463 LFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPI 527
            :.|:...|..|||...||..:|   ...:.|......:|.|   :..|.|.|:.|.|||||:|||
 Frog   344 VLLILAAAGLAIGQTFWEAKLG---AANVSWYLYDGNNYSP---SYRGFLAFWGYIIVLNTMVPI 402

  Fly   528 SLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFN 592
            ||||||||||..||:.||||.:||:...:|.||||||||||:||||||||||||||||||||||.
 Frog   403 SLYVSVEVIRLGQSYFINWDLQMYFSPKDTPAKARTTTLNEQLGQIQYIFSDKTGTLTQNIMTFK 467

  Fly   593 KCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVH 657
            ||:|||.:|||.
 Frog   468 KCTINGTTYGDD----------------------------------------------------- 479

  Fly   658 AKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLD 722
                                                                             
 Frog   480 ----------------------------------------------------------------- 479

  Fly   723 GSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRL 787
                                                                             
 Frog   480 ----------------------------------------------------------------- 479

  Fly   788 VKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSV 852
                                     |:|.:|..|                            :.|
 Frog   480 -------------------------DDELKSGQT----------------------------KQV 491

  Fly   853 DFSANPHHESDFRWYDRTLLDAVRSDEEHS-HVFFRLLALCHTVMAETVDGKLEYQAQSPDEAAL 916
            |||.||..:..|.::|..|::.:|:.::.. :.||:|||||||||||..||:|.|||.||||.||
 Frog   492 DFSWNPLADPSFTFHDNYLIEQIRAGKDKDVYEFFKLLALCHTVMAEKTDGELIYQAASPDEGAL 556

  Fly   917 VSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGDSMV-LYCKGADN 980
            |:|||||||||.:||.::|||..:||.:.||:|.|||||:.|||||:|:|:.|..: |||||||.
 Frog   557 VTAARNFGFVFLSRTQSTITISELGQEKTYEVLAILDFNSDRKRMSIIVRQPDGRIRLYCKGADT 621

  Fly   981 VIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKL 1045
            |||:||| ....:|.:||..|:.||...||||.|..:.:.:..:.:|..:.::|:::..:|::.|
 Frog   622 VIYERLH-PDNPIKDQTQKALDIFANASLRTLCLCYKDINKGDFENWSKKYKQASVATSNRDEAL 685

  Fly  1046 NAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDE 1110
            :.:||.||::::|:|.|||||||||.|..:|.||..|.||||||||||:|||.||||||:||.|
 Frog   686 DRVYEAIETDLKLLGATAIEDKLQDDVSGTIFNLARADIKIWVLTGDKKETAENIGYSCKLLDD- 749

  Fly  1111 LADVFIVDGNSVE-----EVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTS 1170
              |..|:.|..:.     .:|.|..|...:....:. :.|.|.|.|:.::          :..|.
 Frog   750 --DTEILYGEDINVHLQTRMENQRNQMSGNQGAQSN-QSGAFLPTDKKHA----------LIITG 801

  Fly  1171 AFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGG-----PDSAECNNLFGDEKGSEDGGTASIV 1230
            :::.|..|                  ||.|..|..     |.:.|       ||..:
 Frog   802 SWLNEILL------------------EKKKRKKKRLKLKFPRTKE-------EKEQQ-------- 833

  Fly  1231 VDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLA 1295
                      ::.....:.|..:.:..|:|:|.:|.|||||||||.|||:||:|:||.|.|||||
 Frog   834 ----------LHEKLKAYALKEQRQRSFVDLACECSAVICCRVTPKQKAMVVDLVKRYKKAVTLA 888

  Fly  1296 IGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFF 1360
            ||||||||:|||.||||||||||||:|||:|||||.||||||:|||||||||||.||||||||||
 Frog   889 IGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFF 953

  Fly  1361 YKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYT 1425
            ||||:|||.|.|||.|.|||||||::..||::||:.|:|||||.:|:.:||||||.||.|||||.
 Frog   954 YKNFSFTLVHFWYSFFNGFSAQTVYEDWFITLYNVLYSSLPVLLVGLLDQDVSDKLSLAFPRLYV 1018

  Fly  1426 PGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNT 1490
            ||.|..|||.::|..|:.||..|||::|.||||.:...:..:|...||:.:.....||.|::...
 Frog  1019 PGQKDLLFNYKKFFLSLFHGIVTSLIIFFIPYGAFLLTMGQDGEAPSDYQSFAVTTATALVITVN 1083

  Fly  1491 AQISLYTSYWTVVNHVTIWGSLVWYFVLDY----------FYNYVIGGPYVGSLTQAMKDLTFWV 1545
            .||.|.|||||.||..:|:||:..||.:.:          |.:..|   :.|:...|::....|:
 Frog  1084 FQIGLDTSYWTFVNAFSIFGSIAIYFGIMFDLHSAGIHVLFPSMFI---FTGAAPNALRQPYLWL 1145

  Fly  1546 TMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSR---RGRRSVRS 1607
            |:::||...:.|::|.:|....:.||.||||::|..|     ..::|.:.|..:   ||..:.||
 Frog  1146 TIILTVAFCLLPIVALRFLAKTIWPSESDKIQKKGKK-----FKAEVEQRAKPKPFARGVSTRRS 1205

  Fly  1608 GYAFAHQEGFGRLITSGKIMHK 1629
            .|||:||.|:..||:||:.:.|
 Frog  1206 AYAFSHQRGYADLISSGRSIRK 1227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	37/77 (48%)
		Cation_ATPase	891..985	CDD:289987	63/94 (67%)
		HAD_like	<1261..1324	CDD:304363	49/62 (79%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	126/256 (49%)
atp8b1	NP_001025562.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		7/32 (22%)
		P-type_ATPase_APLT_Dnf-like	92..1049	CDD:319770	528/1256 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1798
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D39163at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.030