DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and ATP10D

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	NP_065186.3	Gene:	ATP10D / 57205	HGNCID:	13549	Length:	1426	Species:	Homo sapiens

Alignment Length:	1564	Identity:	475/1564 - (30%)
Similarity:	753/1564 - (48%)	Gaps:	335/1564 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 RRSSY--YFSENERRIRANDKEFNAQFK-----YHNNYIKTSKYSLFTFLPFNLLEQFQRLANFY 240
            |:||.  ..|...|.:..:.:.|..:::     |.||.|:|:||:|..|:|.||.|||.|.||.|
Human    38 RKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVPRNLFEQFHRAANLY 102

  Fly   241 FLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNN-------RKSKTL 298
            ||.|:||..:|.:.:.....|.:||:.|||:.|:||..:|.:::..|.|:||       ||.|
Human   103 FLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEK-- 165

  Fly   299 RNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTET 363
               |.::..|.:|.|||.|||..|:.:.||.:||.:::|:|:|.|||:.||||:|||.:|.:...
Human   166 ---KYIDRCWKDVTVGDFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGY 227

  Fly   364 IELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRG-QRFALDNEKILLRGCVLRNTQWCYGVV 427
            .|.....|. ..|:..|.||.|||.|::|.|.|.... :|..|..|.:|||||.:|||:...|:|
Human   228 AEQDSEVDP-EKFSSRIECESPNNDLSRFRGFLEHSNKERVGLSKENLLLRGCTIRNTEAVVGIV 291

  Fly   428 VFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYL- 491
            |:||.:||.|.|:...::|.:.::|..|..::..|:.||.:|...|:|..||   :.::.:::.
Human   292 VYAGHETKAMLNNSGPRYKRSKLERRANTDVLWCVMLLVIMCLTGAVGHGIW---LSRYEKMHFF 353

  Fly   492 ----PWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYY 552
                |..|||       ...:.|..:|::..|:|..::|||||||:|:::..|.:.|..|.:.|.
Human   354 NVPEPDGHII-------SPLLAGFYMFWTMIILLQVLIPISLYVSIEIVKLGQIYFIQSDVDFYN 411

  Fly   553 PTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSY---------------- 601
            ...::..:.|...:.|:||||||:|||||||||:|.|.|.:||:.|..|
Human   412 EKMDSIVQCRALNIAEDLGQIQYLFSDKTGTLTENKMVFRRCSVAGFDYCHEENARRLESYQEAV 476

  Fly   602 ---GDVIDLRTGELVEITEQQT----IFQNSNTNNRPS-PLSGAIV----APPAAPPPIILVHKA 654
               .|.||..:|.|..:.:.:.    ...|....|:|| .|:|:..    ...|:..|
Human   477 SEDEDFIDTVSGSLSNMAKPRAPSCRTVHNGPLGNKPSNHLAGSSFTLGSGEGASEVP------- 534

  Fly   655 EVHAKKTSMVVTSSGEAQVLPDRPRSD-----IERSAPPMDASEKRPGLK--------------- 699
              |:::.:.  :|..|..|:||....|     ..|...|:|.:.:.|.::
Human   535 --HSRQAAF--SSPIETDVVPDTRLLDKFSQITPRLFMPLDETIQNPPMETLYIIDFFIALAICN 595

  Fly   700 HVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVK 764
            .|..|||::.      |...|....|||  |:.:.|...|         ..||...|.||...:
Human   596 TVVVSAPNQP------RQKIRHPSLGGL--PIKSLEEIKS---------LFQRWSVRRSSSPSL- 642

  Fly   765 ILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHH 829
               :|.:..:..:.::..:|..|    |.:....:.:...:||    :.|.||.:|
Human   643 ---NSGKEPSSGVPNAFVSRLPL----FSRMKPASPVEEEVSQ----VCESPQCSS--------- 687

  Fly   830 HRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHT 894
              |.|..|                       |::.:..|..||:.
Human   688 --SSACCT-----------------------ETEKQHGDAGLLNG-------------------- 707

  Fly   895 VMAETVDGK-----LEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIE--VMGQTEEYELLNIL 952
             .||::.|:     |.|:|:||||||||.|||.:....|:|||..:.::  .:|.. .::||:||
Human   708 -KAESLPGQPLACNLCYEAESPDEAALVYAARAYQCTLRSRTPEQVMVDFAALGPL-TFQLLHIL 770

  Fly   953 DFNNVRKRMSVILRR--GDSMVLYCKGADNVIYDRLHGGQED----------LKARTQDHLNKFA 1005
            .|::|||||||::|.  .:.:|:|.||||:||.:.|.....|          ::.:||.||:.:|
Human   771 PFDSVRKRMSVVVRHPLSNQVVVYTKGADSVIMELLSVASPDGASLEKQQMIVREKTQKHLDDYA 835

  Fly  1006 GEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQD 1070
            .:|||||.:|::.:::..|.:|......|..|:|:||:.|......:|:::.|:|.|.|||:||:
Human   836 KQGLRTLCIAKKVMSDTEYAEWLRNHFLAETSIDNREELLLESAMRLENKLTLLGATGIEDRLQE 900

  Fly  1071 GVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLL--TDELADVFIVDGNS-----------V 1122
            |||:||..|..||||||:|||||||||:||.|:|:||  .|:|   ||::..|           :
Human   901 GVPESIEALHKAGIKIWMLTGDKQETAVNIAYACKLLEPDDKL---FILNTQSKDACGMLMSTIL 962

  Fly  1123 EEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPA 1187
            :|::|:.:...|.:.                        ||..:.|          ||.|
Human   963 KELQKKTQALPEQVS------------------------LSEDLLQ----------PPVP----- 988

  Fly  1188 ISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSP 1252
                                              .|.|..:         .|::.|.:|...|..
Human   989 ----------------------------------RDSGLRA---------GLIITGKTLEFALQE 1010

  Fly  1253 ELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISG 1317
            .|:.:||::.|.|:||:|||.|||||:.||:|::.....:||||||||||||||:.|.||:|:||
Human  1011 SLQKQFLELTSWCQAVVCCRATPLQKSEVVKLVRSHLQVMTLAIGDGANDVSMIQVADIGIGVSG 1075

  Fly  1318 QEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQ 1382
            |||:|||::||::::||::|.:||||||.|.|.|:...:.||||||.|:.....||..|||||..
Human  1076 QEGMQAVMASDFAVSQFKHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGT 1140

  Fly  1383 TVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAF 1447
            ::.|...:..:||.:||.|.:..||.|:|||.:..::.|.||..|.|||.:....|..::|...:
Human  1141 SMTDYWVLIFFNLLFTSAPPVIYGVLEKDVSAETLMQLPELYRSGQKSEAYLPHTFWITLLDAFY 1205

  Fly  1448 TSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSL 1512
            .|||.|.:||..|: |...:.|...:.:...|:...:|      .:.:.:...|.::.:.|.||:
Human  1206 QSLVCFFVPYFTYQ-GSDTDIFAFGNPLNTAALFIVLL------HLVIESKSLTWIHLLVIIGSI 1263

  Fly  1513 VWYFVLDYFYNYVI------GGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPS 1571
            :.||:....:..:.      ..|| ..:.:.|.|..|::..::|....:.|...|:.....:.||
Human  1264 LSYFLFAIVFGAMCVTCNPPSNPY-WIMQEHMLDPVFYLVCILTTSIALLPRFVYRVLQGSLFPS 1327

  Fly  1572 ----------LSDKIRQKSLKKIH-----SRASSDVRRTASSRRGRR---------SVRSGYAFA 1612
                      |:.:.|.|:|||..     ::.:|.....::.:.|||         :::|..:.|
Human  1328 PILRAKHFDRLTPEERTKALKKWRGAGKMNQVTSKYANQSAGKSGRRPMPGPSAVFAMKSASSCA 1392

  Fly  1613 HQEG 1616
            .::|
Human  1393 IEQG 1396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	26/69 (38%)
		Cation_ATPase	891..985	CDD:289987	43/102 (42%)
		HAD_like	<1261..1324	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	75/252 (30%)
ATP10D	NP_065186.3	ATPase-Plipid	71..1327	CDD:273734	454/1460 (31%)
		PhoLip_ATPase_N	<71..122	CDD:292826	25/50 (50%)
		E1-E2_ATPase	128..>216	CDD:278548	37/92 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..531		6/24 (25%)
		Cation_ATPase	<727..807	CDD:289987	37/80 (46%)
		HAD_like	<1051..1082	CDD:304363	24/30 (80%)
		PhoLip_ATPase_C	1082..1327	CDD:292829	75/252 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830