DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8B and ATP10A

DIOPT Version :9

Sequence 1:NP_731669.2 Gene:ATP8B / 41469 FlyBaseID:FBgn0037989 Length:1726 Species:Drosophila melanogaster
Sequence 2:NP_077816.1 Gene:ATP10A / 57194 HGNCID:13542 Length:1499 Species:Homo sapiens


Alignment Length:1558 Identity:500/1558 - (32%)
Similarity:760/1558 - (48%) Gaps:318/1558 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   159 QRDPSVTSESKSVPSLRRLSQIRRR--RSSYY-----------FSENERRIRANDKEFNAQFKYH 210
            :|:|:.| |....|..||..:.|.|  ||:..           .::.|||.|....:..|     
Human     2 EREPAGT-EEPGPPGRRRRREGRTRTVRSNLLPPPGAEDPAAGAAKGERRRRRGCAQHLA----- 60

  Fly   211 NNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVK 275
            :|.:||:||:|.:|||.||.|||.|.||.||:.:.:|..:||:::..|.....|::.:|.:||.:
Human    61 DNRLKTTKYTLLSFLPKNLFEQFHRPANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAITAFR 125

  Fly   276 DAYDDIQRHISDSQVN-------NRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLS 333
            |.::|..||.||.::|       :|:.|     |.|...|.|:.|||.:||..|:...||.||||
Human   126 DLWEDYSRHRSDHKINHLGCLVFSREEK-----KYVNRFWKEIHVGDFVRLRCNEIFPADILLLS 185

  Fly   334 TSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIW 398
            :|:|:|||.||||.||||||||.:|.:....||....:.| .|...|.||:|||.|::|.|.:|.
Human   186 SSDPDGLCHIETANLDGETNLKRRQVVRGFSELVSEFNPL-TFTSVIECEKPNNDLSRFRGCIIH 249

  Fly   399 -RGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIV 462
             .|::..|..|.:|||||.||||....|:|::||.:||.:.|:...::|.:.::|.:|..::..|
Human   250 DNGKKAGLYKENLLLRGCTLRNTDAVVGIVIYAGHETKALLNNSGPRYKRSKLERQMNCDVLWCV 314

  Fly   463 LFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPK----DYIPTGATVIGLLVFFSYAIVLNT 523
            |.||.:....|:|..:|.....:...|:     .:||    ...|..|.|..   |.:..|||..
Human   315 LLLVCMSLFSAVGHGLWIWRYQEKKSLF-----YVPKSDGSSLSPVTAAVYS---FLTMIIVLQV 371

  Fly   524 VVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNI 588
            ::|||||||:|:::..|.:.||.|.::|...|::..:.|...:.|:||||||||||||||||:|.
Human   372 LIPISLYVSIEIVKACQVYFINQDMQLYDEETDSQLQCRALNITEDLGQIQYIFSDKTGTLTENK 436

  Fly   589 MTFNKCSINGRSYGDVIDLRTGEL-----VEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPI 648
            |.|.:|:::|..|..  |.....|     .:..|::.:.:..:.:.|     |:|    .:...:
Human   437 MVFRRCTVSGVEYSH--DANAQRLARYQEADSEEEEVVPRGGSVSQR-----GSI----GSHQSV 490

  Fly   649 ILVHKAE-----------VHAKKTSMV-----VTSSGEAQVLPDRPR-----SDIERSAPPMDAS 692
            .:||:.:           ..||:.||:     .:|..|..:.|| |:     |:.::|.      
Human   491 RVVHRTQSTKSHRRTGSRAEAKRASMLSKHTAFSSPMEKDITPD-PKLLEKVSECDKSL------ 548

  Fly   693 EKRPGLKHVRYSAPSRSQDADAGRLSPRLDG----------------------------SGGLSP 729
                        |.:|.|:.....|||.|..                            ...|..
Human   549 ------------AVARHQEHLLAHLSPELSDVFDFFIALTICNTVVVTSPDQPRTKVRVRFELKS 601

  Fly   730 PVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKK 794
            ||    :.|....:|....|:      ||.|..:..|  :....:|.:..|              
Human   602 PV----KTIEDFLRRFTPSCL------TSGCSSIGSL--AANKSSHKLGSS-------------- 640

  Fly   795 APSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPH 859
            .|||.:...::.:||..|.   |.||.:::..:     .:.|.||:|.                 
Human   641 FPSTPSSDGMLLRLEERLG---QPTSAIASNGY-----SSQADNWASE----------------- 680

  Fly   860 HESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAARNFG 924
                            .:.|:.|                  :.:|.|:|:||||||||.|||.:.
Human   681 ----------------LAQEQES------------------ERELRYEAESPDEAALVYAARAYN 711

  Fly   925 FVFRTRTPNSITIEV--MGQTEEYELLNILDFNNVRKRMSVILRR--GDSMVLYCKGADNVIYDR 985
            .|...|..:.:::|:  :|:. .:|||:.|.|::|||||||::|.  .|.:.:|.||||:|:.|.
Human   712 CVLVERLHDQVSVELPHLGRL-TFELLHTLGFDSVRKRMSVVIRHPLTDEINVYTKGADSVVMDL 775

  Fly   986 L-----------HGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMD 1039
            |           |  |:.::::||::||.:|.||||||.:|:|.|:::.|..|.....||..|::
Human   776 LQPCSSVDARGRH--QKKIRSKTQNYLNVYAAEGLRTLCIAKRVLSKEEYACWLQSHLEAESSLE 838

  Fly  1040 SREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSC 1104
            :.|:.|......:|:.:.|:|.|.|||:||||||::|:.|:.||::||||||||||||:||.|:|
Human   839 NSEELLFQSAIRLETNLHLLGATGIEDRLQDGVPETISKLRQAGLQIWVLTGDKQETAVNIAYAC 903

  Fly  1105 QLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQT 1169
            :||..:            |||                         ..||:.| .:..:..:.|.
Human   904 KLLDHD------------EEV-------------------------ITLNATS-QEACAALLDQC 930

  Fly  1170 SAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDEN 1234
            ..::|...|...|              ||.|    |..|...::|......:..|...|:|:|  
Human   931 LCYVQSRGLQRAP--------------EKTK----GKVSMRFSSLCPPSTSTASGRRPSLVID-- 975

  Fly  1235 TGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDG 1299
                    |.||.:.|...||:|||.:|.||::|:|||.|||||::||:|::....|:|||||||
Human   976 --------GRSLAYALEKNLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDG 1032

  Fly  1300 ANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNF 1364
            |||||||:.|.:|||||||||:|||::||:::.:||||||||::||.|.|.|:...:.||||||.
Human  1033 ANDVSMIQVADVGVGISGQEGMQAVMASDFAVPKFRYLERLLILHGHWCYSRLANMVLYFFYKNT 1097

  Fly  1365 AFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLK 1429
            .|.....|:..||||||.|:.|..::..:||.::|||.|..||.::||.....|..|:||..|..
Human  1098 MFVGLLFWFQFFCGFSASTMIDQWYLIFFNLLFSSLPPLVTGVLDRDVPANVLLTNPQLYKSGQN 1162

  Fly  1430 SELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQIS 1494
            .|.:..|.|.:::...||.|||.|.|||..|.|   :|    .|..|.|..:.||.::.....:.
Human  1163 MEEYRPRTFWFNMADAAFQSLVCFSIPYLAYYD---SN----VDLFTWGTPIVTIALLTFLLHLG 1220

  Fly  1495 LYTSYWTVVNHVTIWGSLVWYFVLDYFYN------YVIGGPYVGSLTQAMKDLTFWVTMLITVMA 1553
            :.|..||.:|.:|...|::.:|.:...||      |....|| .::...:.|..|::|.|:|.:|
Human  1221 IETKTWTWLNWITCGFSVLLFFTVALIYNASCATCYPPSNPY-WTMQALLGDPVFYLTCLMTPVA 1284

  Fly  1554 LVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQEG 1616
            .:.|.|.::.....|.|:.....||.:.|.  .|..|..:.|.:  :||....||  ..|..|
Human  1285 ALLPRLFFRSLQGRVFPTQLQLARQLTRKS--PRRCSAPKETFA--QGRLPKDSG--TEHSSG 1341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8BNP_731669.2 PhoLip_ATPase_N 195..260 CDD:292826 26/64 (41%)
Cation_ATPase 891..985 CDD:289987 38/97 (39%)
HAD_like <1261..1324 CDD:304363 41/62 (66%)
PhoLip_ATPase_C 1324..1571 CDD:292829 88/252 (35%)
ATP10ANP_077816.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..53 14/51 (27%)
PhoLip_ATPase_N 49..108 CDD:292826 26/63 (41%)
ATPase-Plipid 61..1309 CDD:273734 472/1453 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 464..531 12/75 (16%)
Cation_ATPase <697..782 CDD:289987 37/85 (44%)
HAD_like <1026..1057 CDD:304363 25/30 (83%)
PhoLip_ATPase_C 1057..1302 CDD:292829 88/252 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1311..1356 10/37 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1464..1499
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.830

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