DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and atp10d

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	XP_005156631.1	Gene:	atp10d / 571658	ZFINID:	ZDB-GENE-090313-231	Length:	1365	Species:	Danio rerio

Alignment Length:	1543	Identity:	486/1543 - (31%)
Similarity:	742/1543 - (48%)	Gaps:	324/1543 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 PPPNKSDDQELYKQRDPSVTSESKSVPSLRRLSQIRR---RRSSYYFSENERRIRANDKEFNAQF 207
            ||.:..|.|:                |.::|||..||   .|...:.||    .|:..|.|
Zfish    31 PPKSSQDAQD----------------PQVQRLSGKRRVVVSRWDPHHSE----YRSFSKGF---- 71

  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLT 272
              .||.|:|:||:|.:|:|.||.:||.|.||.|||.|::|..:||:.:.....|.|||..|||:.
Zfish    72 --QNNSIRTTKYTLISFIPMNLFQQFHRAANLYFLFLVLLNWVPAVEAFQKEITMIPLAVVLTVI 134

  Fly   273 AVKDAYDDIQRHISDSQVNNRKSKTL--RNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTS 335
            |.|||.:|.:|:..|.::||..:...  :..:.||.:|:||.|||::||..|:.:.||.:||.:|
Zfish   135 AFKDAMEDYRRYRYDKKINNTLTHVYSGKQQRYVERRWAEVCVGDLVRLCCNEIIPADMVLLHSS 199

  Fly   336 EPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRG 400
            :.||:|.||||.||||||||.:|.:.:..:.|..... .||:..|.||.|||.|.:|.|.:...|
Zfish   200 DSNGVCHIETANLDGETNLKQRQVVRDLTQQGAEFVP-ENFSSRIECENPNNDLRRFRGFMEHPG 263

  Fly   401 Q-RFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLF 464
            : |..|.:|.:|||.|.:|||:...|:||:||.:||.|||:...::|.:.::|.||..::..|..
Zfish   264 KVRVGLHSENLLLRSCTVRNTETVIGIVVYAGHETKAMQNNSGPRYKRSKLERRLNLDVLWSVAL 328

  Fly   465 LVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIP--TGATVIGLLVFFSYAIVLNTVVPI 527
            |:.:|.:.|||..:|...:..            |...||  |...:....:|::..|||..::||
Zfish   329 LLLMCFIAAIGHGLWLSELED------------PIFMIPDNTHPALAAFYMFWTMIIVLQVLIPI 381

  Fly   528 SLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFN 592
            |||||:|:::..|.:.|..|.::|.|..:|..:.|...:.|:||||||:|||||||||:|.|.|.
Zfish   382 SLYVSIEIVKLGQIYFIQNDLDLYNPVLDTGVQCRALNITEDLGQIQYLFSDKTGTLTENRMLFR 446

  Fly   593 KCSINGRSY-----------------GDV---IDLRTGELVEITEQQTIFQNSNTNNRPSPLSGA 637
            :|::.|..|                 |||   :.||:.     |.::::...|.:.||.|.....
Zfish   447 RCTVAGTEYPHHENAVSLEQYEDQACGDVDRSLTLRSR-----TSKKSLSCKSLSCNRSSVSLNT 506

  Fly   638 IVAPPAAPPPIILVHKAEVHA------KKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRP 696
            :.|            :::.|:      :.|:...:|:.|..|:|| |:..::.|.
Zfish   507 LTA------------ESDTHSVHDTLCRHTTGAFSSTMECAVVPD-PQLHMKLST---------- 548

  Fly   697 GLKHVRYSAPSRSQ-DADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSC 760
                  .|:|.||. ..||..:|..||....|                              :.|
Zfish   549 ------LSSPMRSPLRPDAAEISLILDFFLAL------------------------------TVC 577

  Fly   761 DKVKILHDSQ----------QTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEE 815
            :.|.:...||          :|...::.......::|...||..:|:|.|            |..
Zfish   578 NTVVVSSPSQPRHVVQMPVVRTPLRSLEEMKAMFQKLSLPRFPHSPNTNT------------DTP 630

  Fly   816 PQSTSTLSTTKHHHHRSKAFATNWSSSPHR-VHALQS-VDFSANPHH----------ESDFRW-- 866
            |..|..|..    ..||.::..|  |:|.. |..|:| |..|..|..          .|...|
Zfish   631 PSLTKKLFA----RGRSASYFPN--SNPQTPVTPLESPVKLSGTPSDTPPALITPALSSSGAWGE 689

  Fly   867 --YDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAARNFGFVFRT 929
              .|:.......:||..|.             .|..:.:|.|:|:||||||||.||:.:|.....
Zfish   690 DAEDKKQAKDNAADESESD-------------DEDEEEELLYEAESPDEAALVQAAKAYGCTLLG 741

  Fly   930 RTPNSITIEVMGQTE-EYELLNILDFNNVRKRMSVILRR---GDSMVLYCKGADNVIYDRLHGGQ 990
            |:|..:.:.|.|... ...||::|.|::.||||||::|.   |: :|:|.|||||||.:.....:
Zfish   742 RSPEQVLVAVPGTGPLSISLLHVLPFHSARKRMSVVVRHPLTGE-VVVYTKGADNVIMELAKQAE 805

  Fly   991 EDLKAR----TQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEE 1051
            :|....    ||.||:::|.||||||.:|::.|.||.|..|..|.:.|..|:::||:.|....|.
Zfish   806 DDFSREVMELTQRHLDQYAREGLRTLCVAKKVLGEQEYEAWMKRHEYAETSIENREELLLESAER 870

  Fly  1052 IESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLL--TDELADV 1114
            :|:::.|:|.|.|.|:||:.||::|..||.||||:||||||||||||||.::|:||  ||.   :
Zfish   871 LETDLTLLGATGIVDRLQEEVPETIEALQEAGIKVWVLTGDKQETAINIAFACKLLRPTDH---I 932

  Fly  1115 FIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLP 1179
            .:.:.:|.|..|.:|::.:..::                         .||
Zfish   933 LMANCDSKEACEARLQELQLEVQ-------------------------QVT-------------- 958

  Fly  1180 PTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGH 1244
                               ..|...|...::|                          .||::|.
Zfish   959 -------------------KADEPEGDCISDC--------------------------VLVIDGR 978

  Fly  1245 SLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAA 1309
            :|.:.|..||:..|||:...|::|||||.|||||:.||.|::.....:||||||||||||||:.|
Zfish   979 TLDYALQKELQGAFLDLTCCCRSVICCRSTPLQKSQVVRLVRDKLEVMTLAIGDGANDVSMIQMA 1043

  Fly  1310 HIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYS 1374
            .:|||||||||:|||:|||::|::|::|.:|:||||.|.|.|:...:.||||||..:.....||.
Zfish  1044 DVGVGISGQEGMQAVMSSDFAISRFKFLRKLILVHGHWCYARLANMILYFFYKNVMYVNLLFWYQ 1108

  Fly  1375 LFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFI 1439
            .|||||..|:.:...:..:||.:||:|.|..||.::|||.:..|:.|.||..|..|:.:....|.
Zfish  1109 FFCGFSGSTMTNSWVLIFFNLLFTSVPPLVYGVLDKDVSAETLLKLPDLYKSGQNSQAYLPTTFW 1173

  Fly  1440 YSVLHGAFTSLVLFLIPY--------GVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLY 1496
            .::|...:.|||.|.|||        ||:......||             :.:||:.....|...
Zfish  1174 LNILDAFYQSLVCFFIPYFAYAGSDIGVFSFASPING-------------SALLIILLHQVIESR 1225

  Fly  1497 TSYWTVVNHVTIWGSLVWYFVLDYFYNYVI----GGPYVGSLTQAMKD-LTFWVTMLITVMALVA 1556
            |..|...:.:...|...:.|||.:....|.    ..|| |..|:.|.: |.:.|.:|.||:||:
Zfish  1226 TLTWIHASLLIFSGLFYYAFVLLFSITCVTCNSPTNPY-GIETKMMSEPLYYLVCVLTTVLALL- 1288

  Fly  1557 PVLAYKFYLLDVHPSLSDKIRQKSLKKIHSR-ASSDVRRTASSRRGRR 1603
            |.:..:.:...:.|  ||.::.:.::::.:: .||.:::...::..:|
Zfish  1289 PRMLSRAFSNTICP--SDLVKAQKIERLSAQDYSSSLQKWKENKATQR 1334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	26/64 (41%)
		Cation_ATPase	891..985	CDD:289987	40/97 (41%)
		HAD_like	<1261..1324	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	82/259 (32%)
atp10d	XP_005156631.1	PhoLip_ATPase_N	69..122	CDD:292826	25/58 (43%)
		ATPase-Plipid	71..1309	CDD:273734	468/1456 (32%)
		E1-E2_ATPase	128..>215	CDD:278548	37/86 (43%)
		Cation_ATPase	<723..799	CDD:289987	35/76 (46%)
		HAD_like	<1027..1074	CDD:304363	33/46 (72%)
		PhoLip_ATPase_C	1058..1303	CDD:292829	83/261 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830