Protein Alignment ATP8B and atp10a

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_021332876.1
• Gene: atp10a / 567172
• ZFINID: ZDB-GENE-101102-1
• Length: 1524
• Species: Danio rerio
• Alignment Length: 1702
• Identity: 494/1702 - (29%)
• Similarity: 796/1702 - (46%)
• Gaps: 359/1702 - (21%)

  Fly   160 RDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRAN---------DKEFNAQFKYHNNYIK 215
            |:...:.|:||    .::.:.:||:|..  ....|.:.||         |   |....|.||.||
Zfish     3 RETGESGETKS----GKVKKHKRRKSKK--ESKTRTVHANILYDHTKGGD---NPNRHYANNKIK 58

  Fly   216 TSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDD 280
            |:||:|.:|||.||.|||.|.||.||:.:.:|..:|.:::..|.....|::.:|::||:||.::|
Zfish    59 TTKYTLLSFLPKNLFEQFHRFANVYFVFIALLNFVPVVNAFQPELALAPVVFILSVTAIKDLWED 123

  Fly   281 IQRHISDSQVNN-------RKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPN 338
            .:||.||.::|:       |..|     :.||..|.|::|||.|||..|:.:.||.||||||:|:
Zfish   124 YRRHRSDKEINHMDCLVYCRSEK-----RYVEKYWKELRVGDFIRLRCNEILPADVLLLSTSDPD 183

  Fly   339 GLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWR-GQR 402
            .||.||||.||||||||.:|.:...|:|....|.| .:|..|.||:|||.||:|.|.:|.| |:|
Zfish   184 RLCHIETATLDGETNLKQRQVVRSFIDLDCEFDPL-KYNSVIECEKPNNDLNRFRGYIIHRSGRR 247

  Fly   403 FALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVS 467
            ..|..:.:|||||.:|||:...|:|::||.:||.|.|:...::|.:.::|.:|..:...|:.|:.
Zfish   248 DGLYKDNLLLRGCTIRNTEEAVGIVIYAGHETKAMLNNNGPRYKRSKLERQMNVDVFWCVIILLV 312

  Fly   468 ICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVS 532
            :|...|||..:|....|....::    .::..:.......|..:.:|.:..||...::||||:||
Zfish   313 MCLFSAIGHGLWMFQYGDKRPVF----DVLGPEGTELSPVVSAIYLFLTMIIVFQVLIPISLFVS 373

  Fly   533 VEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSIN 597
            :|:::..|.:.|:.|.|:|...|:::.:.|...:.|:|||:||||||||||||:|.|.|.:|::.
Zfish   374 IEIVKICQVYFIHQDLELYDEETDSHLQCRALNITEDLGQMQYIFSDKTGTLTENKMVFRRCTVA 438

  Fly   598 GRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRP------SPLSGAIVAPPAAPPPIILVHK--- 653
            |..|....:.|...:.:..|.:.....|:....|      |..||.:|....:...    |:
Zfish   439 GVEYSHDANARRIAMYQEVESEEEDCTSHGGTLPRRDSVASHQSGKVVLRSQSTKS----HRRTG 499

  Fly   654 AEVHAKKTSMV-----VTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQ--- 710
            :...||:.|::     .:|..|..:.||....|        ..:|....::.:|:.:.|.:|
Zfish   500 SRAEAKRASILSKHTAFSSPMEKDITPDPQLMD--------KVNECSSQMEFMRFHSQSLNQIPP 556

  Fly   711 ---DADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQT 772
               |.....::..:..:..:|.|  |:.|               :::.|......||.:.|
Zfish   557 DLCDVFDFFIALTICNTVVVSSP--NQPR---------------QKVRRFELKSPVKTIED---- 600

  Fly   773 ETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFAT 837
                          .:| ||  .||..|.|           ....|:|:|:|.:...|:   ...
Zfish   601 --------------FIK-RF--TPSRLTSG-----------SNSSSSSSLATNRSSSHK---LGC 634

  Fly   838 NWSSSPHRVHALQSVDFSANPHHESDFRW------YDRTLLDAVRSDEEHSHVFFRLLALCHTVM 896
            :..|||...:.|..::......|:....:      :|::  .|:..||            |
Zfish   635 SMLSSPSAENTLTKLNEEKRQEHDLQHAFSPVPPNFDKS--KALAQDE------------C---- 681

  Fly   897 AETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEV--MGQTEEYELLNILDFNNVRK 959
                  :|.::|:||||||||.|||.:......|.|:.:|:|:  :|:. .:|||:.|.|::.||
Zfish   682 ------ELRFEAESPDEAALVYAARAYKCALVGRLPDQVTVELPHLGKL-SFELLHTLGFDSTRK 739

  Fly   960 RMSVILRR--GDSMVLYCKGADNVIYDRLHGGQEDLKA--------RTQDHLNKFAGEGLRTLAL 1014
            ||||:::.  .:.:.:|.||||:||.|.:....:|.|.        :||::||.:|.:|||||.:
Zfish   740 RMSVVVKHPLTEQITVYTKGADSVIMDLIRPATDDCKGKRQRKILYKTQNYLNLYAADGLRTLCI 804

  Fly  1015 AERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANL 1079
            |::.|:::.|..|..|..||..::..||:.|......:|:.:||:|.|.|||:||||||::||:|
Zfish   805 AKKVLSKEEYASWLQRHLEAETAIQRREELLFESALRLETNLQLLGATGIEDRLQDGVPETIASL 869

  Fly  1080 QNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRP 1144
            :.||::|||||||||||||||.|:|:||..|            ||:
Zfish   870 RKAGLQIWVLTGDKQETAINIAYACKLLDPE------------EEI------------------- 903

  Fly  1145 GGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSA 1209
                  ..||:|| .:..:..:..:..::|...|                     .|.:.||.:|
Zfish   904 ------ITLNADS-QEACARLLENSLHYIQAKFL---------------------CDPRAGPQAA 940

  Fly  1210 ECNNLFGDEKG----------SEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQ 1264
                  ||..|          :..|.:...:|..   ..||::|.:|.:.|...||:|||.:|..
Zfish   941 ------GDYAGIHFSSPVCSPTSSGHSGPFLVHR---LGLVIDGRTLAYALDKSLEDKFLAVARS 996

  Fly  1265 CKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDY 1329
            |::|:|||.|||||::||:|::.....:||||||||||||||:.|.:|||||||||:|||::||:
Zfish   997 CRSVLCCRSTPLQKSMVVKLVRNKLKVMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDF 1061

  Fly  1330 SIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYN 1394
            ::.:||||::||||||.|.|.|:...:.||||||..|.....||..:||||...:.|..::..:|
Zfish  1062 ALPRFRYLQKLLLVHGHWCYSRLANMILYFFYKNAMFVALIFWYQFYCGFSGSAMVDQWYLIFFN 1126

  Fly  1395 LFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGV 1459
            |.:::.|.|..|..::|||.:...|.|:||..|..||.:....|..:::...:.||:.|.|||..
Zfish  1127 LMFSAFPQLITGTLDKDVSAETLQELPQLYMNGQNSEEYKPYMFWMNMIDAFYQSLICFFIPYFA 1191

  Fly  1460 YKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYN- 1523
            |.|.       ..|..|.|..:.|:.:......:.:.|..||.:|.|:|..|:..:|.:...||
Zfish  1192 YIDS-------DVDLFTWGTPITTLALFTILLHLGIETKTWTWMNWVSIGFSMALFFTVALCYNA 1249

  Fly  1524 -----YVIGGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYK--------------------- 1562
                 :.....| .::.:.:.|..|::..::|.:|.:.|...|:
Zfish  1250 SCPTCFSPSNTY-WTMQRLLGDPLFYLLCVVTPVAALLPRYCYRACQGTLFPNPVHMGRQLDKLP 1313

  Fly  1563 ---------------------------FYLL------DVHPSL------SDKIRQKSLKKIHSRA 1588
                                       |:.|      |..|..      |.|.::|:|....|..
Zfish  1314 VEMRRLVLSQSQMKLGSLGSLFAPRAPFFPLCRPFQKDYRPKAKQSHVSSTKPKEKALASPISSK 1378

  Fly  1589 SSDVRRT-ASSRRGRRSVRSGYAFAHQEGFGRLITSGKIMHKLPQDFAF---------------- 1636
            |.::|.| .||:.....::..:....:....|..:.|.:    |::..:
Zfish  1379 SVEMRDTPVSSKNSDNHIKLNFRKQDKAQSCRQASDGPV----PENLCYVKEPSSPITGTLPYTK 1439

  Fly  1637 -------------------PLGLGTKKTQVLHN----NLNSADGPNSKGNNVTGHHMVNNNTNMR 1678
                               |.||....|.:|..    .|.|.......|..:....:.|..:.::
Zfish  1440 DTPASRTLLESTGLEVPLSPTGLLLSSTPLLSQTETMQLTSPPASCFLGQKLNDEELSNQKSLLK 1504

  Fly  1679 HNQNQNHSSMAD 1690
            .:|:::||.:.:
Zfish  1505 QSQDRDHSCLPE 1516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	29/73 (40%)
		Cation_ATPase	891..985	CDD:289987	37/97 (38%)
		HAD_like	<1261..1324	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	78/306 (25%)
atp10a	XP_021332876.1	P-type_ATPase_APLT_Dnf-like	54..1188	CDD:319770	426/1300 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830